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Human breast cancer cell inhibitor and preparation method thereof

A technology of human breast cancer cells and inhibitors, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as prone to complications, serious physical damage, and low immunity, and the method is simple Easy to operate, good stability, and growth-inhibiting effect

Inactive Publication Date: 2013-03-20
霍尔果斯美环亿速信息技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment is mainly to remove the diseased part (mastectomy), which is more harmful to the patient, prone to complications, and affects the normal life of the patient.
In addition, bone metastasis of breast cancer is the most common, and most of the surgical patients will develop metastasis or recurrence after two years, and local treatment often cannot achieve the purpose of radical cure
The drugs usually used in radiotherapy and chemotherapy are mostly chemical drugs. Although they can control the development of some cancer cells and relieve symptoms, due to the side effects of chemotherapy drugs, they are harmful to the body, and at the same time, a series of complications and adverse reactions are caused by low immunity. Large, and the cost of treatment is expensive at the same time, a considerable number of patients cannot tolerate adverse reactions and give up treatment
At the same time, cancer cells exposed to sub-lethal concentrations of chemotherapy drugs often develop drug resistance, and often cross-resistance to other anticancer drugs, so the drug resistance of chemotherapy drugs and the occurrence of cancer cell metastasis often make the treatment unreachable. to the desired effect

Method used

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  • Human breast cancer cell inhibitor and preparation method thereof
  • Human breast cancer cell inhibitor and preparation method thereof
  • Human breast cancer cell inhibitor and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] One, preparation method of the present invention:

[0051] (1) The preparation method of 2,2'-bisbenzimidazole is as follows: Weigh 1.42 grams (10 mmol) of ammonium oxalate and 2.16 grams of o-phenylenediamine (20 mmol) as reactants, add 15 mL of glycerol, and mix well Finally, put it into the microwave rapid reaction system and react for 10 minutes at a power of 200w and a temperature of 250°C; then react at a power of 300w and a temperature of 165°C for 11 minutes. Filter and wash with distilled water two to three times to obtain the crude product. Recrystallize the crude product with 100mL of ethylene glycol, filter it with suction, put the product in a drying oven at 80°C, and bake it for 2 hours to obtain a yellow powder compound that is 2,2'-bisbenzimidazole; it was analyzed by infrared spectroscopy Determination, the obtained infrared spectrum is as follows figure 2 shown.

[0052] (1) Zn(NO 3 ) 2 ·6H 2 O (0.5 mmol), 2,2'-bisbenzimidazole (0.25 mmol), 5-hy...

Embodiment 2

[0073] One, preparation method of the present invention:

[0074] (1) The preparation method of 2,2'-bisbenzimidazole is as follows: Weigh 2.84 g (20 mmol) of ammonium oxalate and 4.32 g of o-phenylenediamine (40 mmol) as reactants, add 20 mL of glycerol, and mix well Finally, put it into the microwave rapid reaction system, react at a power of 250w and a temperature of 230°C for 12min; Filter and wash three times with distilled water to obtain the crude product. Recrystallize the crude product with 100mL of ethylene glycol, filter it with suction, put the product in a drying oven at 85°C, and bake it for 1.5h to obtain a yellow powder compound, namely 2,2'-bisbenzimidazole;

[0075] (2) Zn(NO 3 ) 2 ·6H 2 O (0.75mmol), 2,2'-bisbenzimidazole (0.25mmol), 5-hydroxyisophthalic acid (0.50mmol) and 20mL water were placed in a beaker, and then the pH value of the solution was adjusted with triethylamine to 9.0, stir evenly to form a raw material solution, the stirring time is 5m...

Embodiment 3

[0095] One, preparation method of the present invention:

[0096] (1) The preparation method of 2,2'-bisbenzimidazole is as follows: Weigh 2.13 grams (15 mmol) of ammonium oxalate and 3.24 grams of o-phenylenediamine (30 mmol) as reactants, add 23 mL of glycerol, and mix well Finally, put it into the microwave rapid reaction system and react for 15 minutes at a power of 230w and a temperature of 250°C; then react at a power of 320w and a temperature of 160°C for 12 minutes. Filter and wash twice with distilled water to obtain the crude product. Recrystallize the crude product with 100mL of ethylene glycol, filter it with suction, put the product in a drying oven at 90°C, and bake it for 1 hour to obtain a yellow powdery compound that is 2,2'-bisbenzimidazole;

[0097] (2) Zn(NO 3 ) 2 ·6H 2 O (0.5mmol), 2,2'-bisbenzimidazole (0.25mmol), 5-hydroxyisophthalic acid (0.5mmol) and 20mL water were placed in a beaker, and then the pH value of the solution was adjusted with triethy...

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Abstract

The invention discloses a human breast cancer cell inhibitor and a preparation method thereof. The preparation method comprises the following steps of: weighing Zn(NO3)2.6H2O, 2,2'-bis-benzimidazole (Bibim), and 5-hydroxyisoph (OH-H2Bdc) in a molar ratio of (2-3):1:(1-2); adding water and putting into a container, regulating the pH value of the liquid to be between 8.0 and 9.0 with triethylamine; putting the stirred raw material in a reaction kettle, sealing the cover, and heating to a temperature of between 100 and 110 DEG C to react for 45 to 56 hours in an insulating state; and cooling to room temperature by adopting gradient cooling method to obtain a colorless block crystal complex [Zn(OH-H2Bdc)(Bibim)]n, namely the human breast cancer cell inhibitor. The human breast cancer cell inhibitor has the characteristics of good stability and strong inhibition capability, and provides guidance to research and development of anti-human breast cancer medicines.

Description

technical field [0001] The invention belongs to anticancer drugs, in particular to a human breast cancer cell inhibitor and a preparation method. Background technique [0002] Breast cancer (breast cancer) is the first malignant tumor in women in my country. The incidence rate is very high and seriously affects the normal life of women. However, the cause of the disease is not yet clear. may be closely related. [0003] There are currently three main methods of breast cancer treatment: surgery, radiotherapy, and chemotherapy. Surgical treatment is mainly to remove the diseased part (mastectomy), which is more harmful to the patient, prone to complications, and affects the normal life of the patient. In addition, bone metastasis of breast cancer is the most common, and most of the surgical patients will develop metastasis or recurrence after two years, and local treatment often cannot achieve the purpose of radical cure. The drugs usually used in radiotherapy and chemothera...

Claims

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Application Information

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IPC IPC(8): A61K31/555A61P35/00C07F3/06
Inventor 杨燕罗旭健颜六廷
Owner 霍尔果斯美环亿速信息技术有限公司
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