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Thiamine nitrate particle and preparation method thereof

A technology of thiamine nitrate and granules, which is applied in food preparation, food science, bulk transportation, etc. It can solve the problems of large difference in tablet weight, difficult premixing, and large dust production, and achieves low cost, good fluidity, Effect of reducing dust generation

Inactive Publication Date: 2013-03-27
HUAZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the original powder of thiamine nitrate is a crystalline powder with poor fluidity, it produces a large amount of dust during application, and it is difficult to premix. There are problems such as large difference in tablet weight and easy splitting when directly compressed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 750g of thiamine nitrate, add 50g of water, stir it into a paste in a wet granulator, add 10g of hydroxypropyl methylcellulose, stir evenly to form wet granules, and dry the wet granules in a fluidized bed at 75°C Dry, and then pass through a 20-mesh vibrating sieve to obtain thiamine nitrate granules.

[0018] Sampling and analysis revealed that the content of thiamine nitrate was 97.88%, and the moisture content was 0.5%.

Embodiment 2

[0020] Get 750g of thiamine nitrate, add 150g of 95% by weight ethanol aqueous solution, after stirring into a paste in a wet granulator, after stirring into a paste, add 3g hydroxypropyl methylcellulose, 2g povidone, stir to make Form into wet granules, dry the wet granules in a fluidized bed at 85°C, and pass through a 40-mesh vibrating sieve to obtain thiamine nitrate granules.

[0021] Sampling and analysis revealed that the content of thiamine nitrate was 98.23%, and the moisture content was 0.3%.

Embodiment 3

[0023] Take 750g of thiamine nitrate, add 100g of 40% by weight ethanol aqueous solution, stir into a paste in a wet granulator, after stirring into a paste, add 2g of hydroxypropyl methylcellulose, 5g of microcrystalline cellulose, and stir evenly Make it into wet granules, dry the wet granules in a fluidized bed at 75°C, and pass through an 80-mesh vibrating sieve to obtain thiamine nitrate granules.

[0024] Sampling and analysis revealed that the content of thiamine nitrate was 98.08%, and the moisture content was 0.4%.

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PUM

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Abstract

The invention belongs to the technical fields of medicines and health care products, and in particular relates to a thiamine nitrate particle. In the particle, thiamine nitrate is adopted as an active component supplemented with other pharmaceutical adjuvant materials which comprise dispersion carriers and inclusion compounds. The particle solves the problem of improper taste in the field of application and is used for preparing chewable tablets.

Description

technical field [0001] The invention relates to a chemical drug and a preparation method thereof, in particular to a thiamine nitrate granule and a preparation method thereof. Background technique [0002] Thiamin Nitrate as Vitamin B 1 The nitrate in the body participates in the catabolism of sugar in the form of coenzyme, which has the effect of protecting the nervous system; it can also promote gastrointestinal motility and increase appetite. Vitamin B 1 When it is lacking, it can cause a variety of neuroinflammation, and the peripheral nerve endings of patients have inflammation and degeneration, accompanied by symptoms such as numbness of limbs, muscle atrophy, heart failure, and edema of lower limbs. Thiamin Nitrate vs Vitamin B 1 Hydrochloride has low water solubility and is relatively stable to alkali, so it is more stable than hydrochloride when used for food fortification. It is widely used in medicine, health care products, food and feed industries. It is often...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/51A23L1/302A61P3/02A23L33/15
Inventor 王勇李新宇付林吴淑梅姬广欣徐勇
Owner HUAZHONG PHARMA
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