Bee venom compound with sun-proof effect

A composition and technology of bee venom, applied in the direction of drug combination, skin care preparations, cosmetics, etc., can solve the problems of skin irritation and phototoxicity, skin dependence, easy to clog pores, etc., and achieve good spreadability and reduce skin damage. Damage, no skin irritation effect

Active Publication Date: 2013-04-03
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a safer and more efficient sunscreen cosmetics for the problems that the existing sunscreen cosmetics have strong irritation and phototoxicity to the skin, a large amount of use will cause the skin to become dependent, the skin feels greasy, has poor air permeability, and is easy to clog pores. Bee venom composition with sun protection effect

Method used

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  • Bee venom compound with sun-proof effect
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Use a bee venom collector to collect crude wasp venom, add 25 volumes of water to fully dissolve it, centrifuge at 8000 g for 15 minutes, ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10000 Da, and freeze-dry the filtrate to obtain bee venom.

[0038] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:

[0039] Phase A: 1% terephthalmethylene dicamphorsulfonic acid, 0.1% carbomer, 0.8% NaCl, 5% 1,3-butanediol, 4% propylene glycol, EDTA-2Na0.1%, deionized water margin.

[0040] Phase B: 1.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.3% ethylhexyl methoxycinnamate, 1% cresyl trisiloxane, micron diamond-type oily TiO 2 Dispersion liquid 9% (containing TiO 2 1.5%), fatty alcohol polyoxyethylene ether 3%, C 12 -C 15 Alkyl Benzoate 9%, Dioctyl Carbonate 2%, Microcrystalline Wax 0.8%, Azone / PEG-40 Hydroge...

Embodiment 2

[0046] The crude bee venom was collected by a bee venom collector, fully dissolved by adding 10 times the volume of water, centrifuged at 5000g for 30min, the supernatant was ultrafiltered through an ultrafiltration membrane with a molecular weight cut-off of 10000Da, and the filtrate was freeze-dried to obtain bee venom.

[0047] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:

[0048] Phase A: 1.5% disodium salt of 2,2′-bis-(1,4-phenylene) 1H-benzimidazole-4,6-disulfonic acid, methylene bis-benzotriazolyl tetra 1% methyl butylphenol, 0.2% carbomer, 4% glycerin, 3% propylene glycol, and the balance of deionized water.

[0049] Phase B: bis-ethylhexyloxyphenol methoxyphenyl triazine 0.2%, ethylhexyl methoxycinnamate 8%, TiO 2 / Hydrated Silica / Aluminum Hydroxide / Dimethicone / Methylsiloxane Copolymer 0.5%, Ceteareth-2 1.5%, Cetearyl Ether-212%, Jojoba Oil 3 %...

Embodiment 3

[0055] Purchase wasp crude bee venom from Wuhan Yimin Bee Products Co., Ltd., add 30 times the volume of water to fully dissolve, centrifuge at 10,000 g for 10 minutes, and ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Da, then freeze-dry the filtrate to obtain bee venom .

[0056] Use a bee venom collector to collect crude bee venom, add 30 times the volume of water to fully dissolve, centrifuge at 10,000 g for 10 min, and ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Da, then freeze-dry the filtrate to obtain bee venom.

[0057] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:

[0058] Phase A: methylenebis-benzotriazolyltetramethylbutylphenol 0.1%, terexylylenebiscamphorsulfonic acid 4.5%, phenylbenzimidazolesulfonic acid and its potassium, sodi...

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Abstract

The invention discloses a bee venom compound with a sun-proof effect. The bee venom compound comprises a sun-proof cosmetic substrate component and bee venom. According to the invention, the bee venom is applied to sun-proof cosmetics for the first time, can effectively prevent ultraviolet ray from hurting skin, relieve scytitis caused by sunburn, and meanwhile enable the skin to keep humidification, provide nutrient for the skin, prompt the rehabilitation of hurt skin, and improve the self-protecting ability of the skin. And in addition, according to the invention, the bee venom, algal polysaccharides and Vc phosphate magnesium are compounded, thus the effects (including sun resistance, diminish inflammation, repair after being exposed to the sun and the like) of the bee venom compound are enhanced. The bee venom compound with the sun-proof effect comprises cream, emulsion, water aqua, gelatum and jelly, and is suitable for crowd with various skin types.

Description

Technical field: [0001] The invention belongs to the field of cosmetics, in particular to a bee venom composition with sunscreen effect. Background technique: [0002] With the aggravation of environmental pollution and the degree of destruction of the atmosphere, the ultraviolet rays irradiated on the ground are also becoming more and more intense. Among them, UVB (ie, medium-wave ultraviolet rays) has the strongest ability to act on the skin, reaching the surface of the dermis, making the blood vessels of the dermis dilate and appear red and swollen, and the nucleic acid or protein in the epidermal cells is denatured. After long-term exposure, the skin will appear edema, blisters, erythema, peeling, aging, and even cause skin cancer. And UVA (that is, long-wave ultraviolet rays) has stronger penetrating power, can reach deep in the dermis, and has a cumulative effect on the skin. After long-term exposure, the skin will brown, collagen fibers will break, elasticity will d...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/73A61P17/04A61Q19/00
CPCA61K8/987A61Q17/00A61K8/73A61Q17/04A61K8/98A61P17/04
Inventor 陈华孙恢礼潘剑宇蔡冰娜孙小钰
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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