36 results about "Skin impairment" patented technology

Biocompatible materials are propelled at the skin with sufficient velocity to cause desired resurfacing of skin layers to the desired penetration depth. The materials, such as dry ice or water ice, are harmonious with the human body and thus eliminate foreign body reactions. Various materials may be used in combination, including local anesthetics and vasoconstrictors in solid or liquid form. The biocompatible solid or liquid particles are suspended in a cold carrier fluid and propelled through an insulated delivery system to the surface of the skin. The treatment of diseased skin lesions may be accomplished using the present invention as a drug delivery system.

A device and method to non-invasively identify pathological skin lesions. The method and device detect and identify of different kinds of skin nevi, tumors, lesions and cancers (namely, melanoma) by combined analyses of visible and infra-red optical signals based on integral and spectral regimes for detection and imaging leading earlier warning and treatment of potentially dangerous conditions.

A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and / or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35° C. and less than 150° C., and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.

Aspects of the invention relate to methods and devices for evaluating tissue injuries. In some embodiments, the invention provides methods and devices for evaluating tissue injuries based on infrared emission spectra and / or emission levels from injured tissue. In some embodiments, the invention provides methods and devices for evaluating skin injuries (e.g., skin burns) and for targeting treatment delivery to injuries including skin injuries.

The invention relates to an anti-sensitization and restoration external preparation for skin, belonging to the technical field of Chinese medicinal preparations. Based on the research and treatment principle of the pathogenic mechanism of skin impairment aggravation of a patient caused by sensitive or allergic dermatitis and hormone therapy sensitive or allergic dermatitis according to the traditional Chinese medicine and in combination with other component raw materials, active ingredients contained in the preparation have the effects of clearing away heat and toxic materials, resisting sensitization, restoring, converging and increasing skin elasticity and luster. The preparation can be prepared into cream or water aqua. The anti-sensitization and restoration external preparation is directly applied to the infection focuses of the patient, has no toxic or side effect, has a good curative effect, is easy to use, and is suitable for the patient suffering from skin impairment caused bysensitive or allergic dermatitis and hormone therapy sensitive or allergic dermatitis; and the problems of larger skin impairment of the patient caused by the conventional hormone therapy of sensitive or allergic dermatitis, difficulty in treating and poor curative effect are solved.

The present invention relates to a hair cosmetic composition capable of treating hairs without causing damages to hairs and injuries of skins and having oxidation fixing effect of permanent wave and dyeing effect equal to or superior to those in a usual case. Specifically, it relates to a hair cosmetic composition comprising a polyphenol derivative obtainable by subjecting a polyphenol to a reaction using an alkaline solvent under the coexistence of oxygen molecules at a pH value during reaction of 6.5 or more.

This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

The invention relates to methods for prevention and / or treatment of skin lesions caused by exposure to ultraviolet radiation. Exemplary condition that can be prevented or treated are actinic keratosis, dry skin, polymorphic light exanthema, photopathology, photo-allergy, solar atrophy, stria migrans, elastoma diffusum, X-ray dermatitis, gouty polychondritis and decubitis ulcer. The method employs application to the skin of a composition comprising a hydroximic acid derivative of the formula

A composition and method for treatment of viral-induced skin lesions, such as warts, are described. The composition is comprised of tea tree oil and / or derivatives from tea tree oil and one or more minerals, such as iodide and / or selenium. The composition is used to prepare medicaments for the treatment of viral-induced lesions, such as warts caused by the Molluscum contagiosum virus, human papillomavirus, and / or herpes simplex virus. The composition is applied topically to the human epidermis and / or to the genital tract as needed.

Photoprotective agents useful for the treatment or prevention of cell damage, particularly skin injury due to UV-light. Methods of prevention or treatment of cell damage and skin injury due to exposure to UV-light, particularly UVB-light. Methods include administration of an effective amount of one or more photoprotective N-mercaptoalkanoylcysteine derivatives of this invention, particularly bucillamine or a salt or solvate thereof, to a mammal, particularly a human, which has been or will be exposed to UV-light. Administration may be oral, topical or parenteral.

The invention discloses a bee venom compound with a sun-proof effect. The bee venom compound comprises a sun-proof cosmetic substrate component and bee venom. According to the invention, the bee venom is applied to sun-proof cosmetics for the first time, can effectively prevent ultraviolet ray from hurting skin, relieve scytitis caused by sunburn, and meanwhile enable the skin to keep humidification, provide nutrient for the skin, prompt the rehabilitation of hurt skin, and improve the self-protecting ability of the skin. And in addition, according to the invention, the bee venom, algal polysaccharides and Vc phosphate magnesium are compounded, thus the effects (including sun resistance, diminish inflammation, repair after being exposed to the sun and the like) of the bee venom compound are enhanced. The bee venom compound with the sun-proof effect comprises cream, emulsion, water aqua, gelatum and jelly, and is suitable for crowd with various skin types.

The present invention is directed to the prophylatic field treatment of photodamaged skin with topical ingenol mebutate. More specifically, the present invention concerns field-directed treatment of UV-damaged skin with topical ingenol mebutate for reducing the number of skin lesions that emerge from the UV-damaged skin over time. In addition, the present invention concerns field-directed treatment for removing photodamaged skin, mutated keratinocytes, cutaneous immunosuppressive environments and / or p53+ patches caused by UV with topical ingenol mebutate. By way of example, the present invention is directed to treating photodamaged skin with topical ingenol mebutate at about 0.05% concentration.The present invention is also concerned with the treatment of SCC tumors with topical ingenol mebutate for reducing the number of SCC tumors. By example, the present invention is directed to treating and curing SCC xenografts with topical ingenol mebutate at about 0.25% concentration.The present invention is further directed to a topical field-directed treatment for the removal of tattoos from skin with ingenol mebutate. By way of example, the present invention is directed to removing tattoos with topical ingenol mebutate at concentrations of up to about 0.25%.

The present invention provides pharmaceuticals or cosmetics, which prevent sclerotic lesions causing apoptosis, degeneration, fibrosis and atrophy, and repair and regenerate the lesions selectively, comprising a compound which preferentially increases regeneration-promoting macrophages and a method for screening the compound which preferentially increases regeneration-promoting macrophages. Pharmaceuticals or cosmetics of the present invention are useful for renal lesions, pancreatic lesions and skin lesions, because these induce regeneration-promoting immunocompetent cells lesion-selectively against organ tissue disorders and cause repair and regeneration thereof.

The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and / or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (GCS) inhibitors) for the treatment of cutaneous wounds.

The invention relates to a Chinese medicine for curing radiation-induced shin injuries. The medicine is mainly composed of the following raw medicinal materials with the following weight ratio and produced by the following technology: 5 portions of angelica dahurica, 15 portions of gromwell root, 15 portions of aloe, 10 portions of coptis chinensis, and 5 portions of dragon's blood, with every portion equal to 1 gram; every 100 kilograms of medicinal materials is added with about 1000L of distilled water and decocted for three times; for the first time the medicinal mixture obtained is decocted on a slow fire for 1.5 hours to 2.5 hours and a medicinal liquor of the first time is strained for further usage; for the second time, 7.5 times to 10.5 times of water is added to decoct for 1.5 hours, a medicinal liquor of the second time is strained for further usage; for the third time, 5 times to 7.5 times of water is added to decoct for 1 hour, a medicinal liquor of the third time is strained for further usage; the medicinal liquors of the three times are mixed, filtered and condensed to a thick paste with the relative density of 1.15 for further usage; the thick paste is baked at low temperature for 10 hours to obtain dry extract powder; borneol and other auxiliary materials are added according to a weight percentage of 1:0.5 of the dry extract powder to dextrin and the mixture obtained is stirred to obtain the medicine. The prescription has the efficacies of cleaning heat, removing itch, easing pain, resisting bacteria, and the like, and is capable of increasing blood circulatory at partial skin, eliminating tumescence and stopping pain.

The invention discloses a weight reducing and body slimming traditional Chinese medicine compound medicine patch, which comprises a traditional Chinese medicine compound and an auxiliary base, and is characterized in that the effective components for preparing the traditional Chinese medicine compound medicine patch in the traditional Chinese medicine compound comprise, by weight, 10-30 parts of angelica sinensis, 10-30 parts of cinnamomum cassia presl, 3-25 parts of crocus sativus l, and 5-30 parts of panax notoginseng, and the medicine patch auxiliary base comprises glycerin, carbomer and other emulsifiers adopted as the plasticizer, the surfactant, the skin moisturizing agent and the like. According to the present invention, the drugs with effects of blood circulation activation, blood fat reducing and yang supplementing are selected to form the prescription, such that the symptom and root cause treatment combining qi-blood circulation regulating and blood fat reducing can be achieved, the weight reducing effect is stable and lasting, and the weight does not rebound; and the skin improving agent is added to the auxiliary base to eliminate the damage on the skin at the adhering position and enhance the absorption of the drug, such that the shortcomings in the prior art are overcome.

The invention provides a method for determining the presence of high molecular weight molecules, aminoacid molecules or protein fragments, in human or other mammalian skin, comprising irradiating a sample of the said skin with light at one or more wavelengths present in solar radiation, in the presence of a spin-trapping agent for radicals of said molecules, and using comparative electron spin resonance (ESR) spectroscopy to determine or investigate the presence of radicals of the said molecules induced in the skin by the light. The method may be used to investigate a range of skin and other tissue damage and the efficacy of agents and methods intended to protect skin from damage.

It has been discovered that granulocyte macrophage colony stimulating factor (“GM-CSF”) promotes migration of activated (but not differentiating) keratinocytes to wound sites. It was also discovered that GM-CSF increases the quantity and improves the quality of collagen. This growth factor specifically increases migration of keratinocytes of the “wound” phenotype but does not have significant effects upon differentiated keratinocytes. Examples demonstrate reversal of skin impairment in multiple animal models of diabetic skin imparment when provided in an effective amount over an effective time period. The examples also demonstrate the efficacy of the formulations in cosmetic applications. A preferred formulation is a sustained release formulation that delivers sufficient growth factor to the skin and the underlying tissue thereof to increase the rate of keratinocyte migration, as well as collagen deposition and fibroblast proliferation, in the skin to promote rejuvenation of skin injuries resistant to repair due to underlying disease, such as diabetes, or aging.

The invention relates to the use of topical formulations containing epidermal growth factor which is encapsulated or associated with standard or deformable liposomes, which are intended to be applied to and around chronic ischemic skin lesions. The inventive formulations, in contrast to the prior art, are useful in that they enable a high bioavailability of the epidermal growth factor in the deep tissue below the lesion and for preventing diabetic foot amputation.

The invention relates to a growth factor slow-release type double-layered artificial skin which is used for repairing injured skin with related growth factor slow-release functions and a preparation method thereof. The artificial skin is divided into two layers of an epidermal layer and an enderonic layer, wherein the epidermal layer is constituted by a micropore double-layered thin film with the functions of water proofing, ventilation and enderonic protection; the materials of the upper layer which contacts with air is polyurethane, or silicon rubber, or polyethylene glycol, or ethylene terephthalate and other medical materials; the lower layer which contacts with the dermis is a natural biological macromolecule thin film which is constructed by silk fibroin and chitosan; the enderonic layer of the artificial skin is constituted by collagen, polysaccharide and microspheres carrying growth factors related to skin regeneration and repairing; the microspheres have good slow-release function, and the slow-release period is equal to or slightly longer than the degradation period of the collagen and polysaccharide and can be matched with the skin regeneration and repairing period; and the thickness of the artificial skin is in a range of 0.5-1.5mm and can be regulated according to requirements.

Methods and systems for treating skin disease are disclosed. Heat is applied at a controlled temperature, for a predetermined period of time, to a skin lesion associated with a skin disease according to embodiments. The temperature used, according to embodiments, is in a range between about 46-62° C., and controlled within a narrow tolerance depending upon the nature of the skin treatment.

A Chinese medicine including interior-applied and exterior-applied medicines for whitening skin and treating pigmented spots, pigmentation, itching, skin rash, photosensitive dermatitis, etc is prepared from 4-5 Chinese-medicinal materials including ash bark, mulberry leaf, buffalo horn, etc.

Methods and devices for the treatment of skin lesions resulting from bacterial, fungal or viral infections or from exposure to irritants are disclosed. The invention relates methods and devices for delivering a controlled dose of thermal energy to the infected or irritated tissue and thereby speed the recovery process.

It has been discovered that granulocyte macrophage colony stimulating factor (“GM-CSF”) promotes migration of activated (but not differentiating) keratinocytes to wound sites. It was also discovered that GM-CSF increases the quantity and improves the quality of collagen. This growth factor specifically increases migration of keratinocytes of the “wound” phenotype but does not have significant effects upon differentiated keratinocytes. Examples demonstrate reversal of skin impairment in multiple animal models of diabetic skin imparment when provided in an effective amount over an effective time period. The examples also demonstrate the efficacy of the formulations in cosmetic applications. A preferred formulation is a sustained release formulation that delivers sufficient growth factor to the skin and the underlying tissue thereof to increase the rate of keratinocyte migration, as well as collagen deposition and fibroblast proliferation, in the skin to promote rejuvenation of skin injuries resistant to repair due to underlying disease, such as diabetes, or aging.

An adhesive skin protector that filters sunlight harmful to skin lesions, the protector comprising at least one adhesive layer adapted to adhere to an area of skin having a skin lesion; and at least one filter layer attached to said adhesive layer, the at least one filter layer being adapted to filter sunlight harmful to the skin lesion.

The invention relates to a composition for treating skin itch. The composition contains activated zeolite powder. According to the present invention, hundreds of patients use the composition provided by the present invention, the use results show that: the composition provides exact itching relieving effects for the skin itches caused by a plurality of skin diseases and unknown causes; because the skin itch of the patients is reduced, the scratching of the patients is reduced, such that the skin lesions caused by the scratching can be significantly improved.

A Chinese medicine including interior-applied and exterior-applied medicines for whitening skin and treating pigmented spots, pigmentation, itching, skin rash, photosensitive dermatitis, etc is prepared from 4-5 Chinese-medicinal materials including ash bark, mulberry leaf, buffalo horn, etc.

The present invention is related to the use of topical formulations that contain epidermal growth factor encapsulated in or associated to deformable or conventional liposomes to be applied on the surface of and around chronic ischemic skin lesions. The formulations of the present invention, in contrast with the previous art, are useful because they provide a high bioavailability of EGF in the tissue deep below the lesions and for preventing diabetic foot amputation.