Moistureproof coating method of dangfei liganning capsule

A Feiliganning and coating technology, which is applied in the moisture-proof coating field of Dangfeiliganning capsule granules, can solve the problems of lower production efficiency, easy moisture absorption, and prolong production cycle, so as to reduce material loss and stabilize quality , the effect of increasing the yield

Active Publication Date: 2013-04-17
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dangfei Liganning Capsules are made of Dangdao and the alcohol-extracted extract of milk thistle and then filled into granules. Due to the high extraction yield of raw materials, it is no longer possible to add other excipients in the process of preparing granules, while the alcohol-extracted The granules made of extracts have strong hygroscopicity, which makes the product easy to absorb moisture during the capsule filling process, resulting in difficult control of product weight differences, and the granules after moisture absorption stick to the capsule shell and are not easy to remove, affecting production efficiency and product quality. Appearance Quality
Secondly, during the storage process, the product will absorb the moisture in the capsule shell, making the capsule shell lose water and become brittle and easy to break, causing many product quality complaints. Problems such as exceeding the control requirements of the national pharmacopoeia for capsules, and the properties do not meet the quality standards
The above problems not only affect the product quality and drug efficacy, but also affect the image of the enterprise, and will bring economic losses to the enterprise
[0003] Therefore, expensive moisture-proof packaging or aluminum foil moisture-proof bags are generally used to prevent moisture, which increases the production process and cost accordingly, prolongs the production cycle, and reduces production efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Milk thistle 900g as medicine 950g

[0019] 1. Take 900g of the main medicine and use 95% ethanol, 75% ethanol and 50% ethanol to extract 2 hours, 1.5 hours, and 1.5 hours, respectively, with 2 times the amount of raw materials, respectively, filter, combine the filtrates, recover ethanol and concentrate until the specific gravity of the extract is 1.25 ~1.35g / ml (measured at 60~80°C), add 50g of fine powder of the drug, dry at a vacuum of -0.09Mpa, vapor pressure of 0.25Mpa, and a temperature of 100°C for 14±2 hours, and crush it into a fine powder. Dry cream powder 220g, set aside.

[0020] 2. Take 900g of milk thistle, crush and remove the oil, slowly percolate with 80% ethanol, collect 5 times the amount of percolation liquid, and concentrate in vacuum at -0.2MPa to a thick liquid with a specific gravity of 1.20-1.25 g / ml (measured at 60°C). The paste is dried at a temperature of 60-70°C and a vacuum of -0.06--0.09MPa for 12-14 hours to obtain dry paste of total fl...

Embodiment 2

[0027] Milk thistle 900g as medicine 950g

[0028] 1. Take 900g of the main medicine and use 95% ethanol, 75% ethanol and 50% ethanol to extract 2 hours, 1.5 hours, and 1.5 hours, respectively, with 2 times the amount of raw materials, respectively, filter, combine the filtrates, recover ethanol and concentrate until the specific gravity of the extract is 1.25 ~1.35g / ml (measured at 60~80°C), add 50g of fine powder of the drug, dry at a vacuum of -0.09Mpa, vapor pressure of 0.25Mpa, and a temperature of 100°C for 14±2 hours, and crush it into a fine powder. Dry cream powder 220g, set aside.

[0029] 2. Take 900g of milk thistle, crush and remove the oil, slowly percolate with 80% ethanol, collect 5 times the amount of percolation liquid, and concentrate in vacuum at -0.2MPa to a thick liquid with a specific gravity of 1.20-1.25 g / ml (measured at 60°C). The paste is dried at a temperature of 60-70°C and a vacuum of -0.06--0.09MPa for 12-14 hours to obtain dry paste of total fl...

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PUM

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Abstract

The present invention provides a moistureproof coating method of dangfei liganning capsule. The method includes the steps of: (1) taking 220 g of swertia pseudochinensis dry cream and 30 g of silibinin total flavonoids, setting the slurry mixing at low speed and a granulating knife at low speed, blending, sieving, and mixing again; (2) spraying the mixed material in a drying granulating machine, preheating, spraying into a coating liquid, spraying, granulating, and coating, wherein the dosage of the coating liquid accounts for 1.5-2% of granule weight gain; (3) tidying the coated granules, sieving, filling, and making into capsule products. The low viscosity coating formulation and coating process are used by the invention preferably. The granule weight gain is only 1.5-2%. The method both solves the moisture absorption problem of dangfei liganning capsule and makes the products satisfy the rules of quality standards. Under the condition of unchanging the production environment, conventional production equipments are used for process improvement, the material loss is reduced in the process of material preparation, the yield is improved, and the stable quality of products is guaranteed in the period of validity.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a moisture-proof coating method for Dangfei Liganning capsule granules. Background technique [0002] Dangfei Liganning Capsules are made of Dangdao and the alcohol-extracted extract of milk thistle and then filled into granules. Due to the high extraction yield of raw materials, it is no longer possible to add other excipients in the process of preparing granules, while the alcohol-extracted The granules made of extracts have strong hygroscopicity, which makes the product easy to absorb moisture during the capsule filling process, resulting in difficult control of product weight differences, and the granules after moisture absorption stick to the capsule shell and are not easy to remove, affecting production efficiency and product quality. Appearance Quality. Secondly, during the storage process, the product will absorb the moisture in the capsule shell, making the capsule shell lose wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61K36/51A61K47/38A61K9/48A61P1/16
Inventor 卿光明钟瑛
Owner SICHUAN MEDCO PHARML
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