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Propranolol hydrochloride cream used for treating infantile hemangioma, and preparation method thereof

A propranolol hydrochloride cream and a technology of propranolol hydrochloride are applied in the directions of cardiovascular system diseases, medical preparations containing active ingredients, and ointment delivery, etc., and can solve the problem that the patch is not suitable for the treatment of infantile hemangioma. , to avoid adverse reactions, reduce drug side effects, and achieve the effect of exact curative effect

Inactive Publication Date: 2013-04-24
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This study proposed for the first time the preparation of propranolol hydrochloride cream for the treatment of infantile hemangiomas. Although there were studies on propranolol hydrochloride transdermal drug delivery system in previous studies, all of them were used for the treatment of hypertension; Propranolol hydrochloride is prepared into a patch, because the treatment cycle of infantile hemangioma is as long as half a year, so the patch is obviously not suitable for the treatment of infantile hemangioma

Method used

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  • Propranolol hydrochloride cream used for treating infantile hemangioma, and preparation method thereof
  • Propranolol hydrochloride cream used for treating infantile hemangioma, and preparation method thereof
  • Propranolol hydrochloride cream used for treating infantile hemangioma, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of propranolol hydrochloride cream for treating infantile hemangioma, is made up of the component of following percentage by weight: propranolol hydrochloride 1%, stearyl alcohol 6.5%, glyceryl monostearate 6.5%, Stearic acid 6.5%, liquid paraffin 9%, glycerin 9%, propylene glycol 9%, sodium lauryl sulfate 2%, azone 0.5%, ethylparaben 0.1%, and the balance is water.

[0029] The preparation method of above-mentioned propranolol hydrochloride cream, comprises the following steps:

[0030] 1) Mix stearyl alcohol, glyceryl monostearate, stearic acid, and liquid paraffin, heat to melt, dissolve in water and control the temperature at 70°C to obtain an oil phase;

[0031] 2) Boil part of the water and mix it with ethylparaben, stir until it is completely dissolved, add the remaining water, glycerin, propylene glycol, sodium lauryl sulfate, azone, propranolol hydrochloride, and control the temperature of the water bath at 70°C to obtain water box;

[0032] 3) Add the...

Embodiment 2

[0035] A kind of propranolol hydrochloride cream for treating infantile hemangioma, is made up of the component of following percentage by weight: propranolol hydrochloride 0.8%, stearyl alcohol 8%, glyceryl monostearate 8%, Stearic acid 5.5%, liquid paraffin 7.5%, glycerin 10.5%, propylene glycol 7.5%, sodium lauryl sulfate 2.5%, azone 0.4%, ethylparaben 0.08%, and the balance is water.

[0036] The preparation method of above-mentioned propranolol hydrochloride cream, comprises the following steps:

[0037] 1) Mix stearyl alcohol, glyceryl monostearate, stearic acid, and liquid paraffin, heat to melt, dissolve in water and control the temperature at 60°C to obtain an oil phase;

[0038] 2) Boil part of the water and mix it with ethylparaben, stir until completely dissolved, add the remaining water, glycerin, propylene glycol, sodium lauryl sulfate, azone, propranolol hydrochloride, and control the temperature of the water bath at 60°C to obtain water box;

[0039] 3) Add t...

Embodiment 3

[0041] A kind of propranolol hydrochloride cream for treating infantile hemangioma, is made up of the component of following percentage by weight: propranolol hydrochloride 1.2%, stearyl alcohol 5.5%, glyceryl monostearate 5.5%, Stearic acid 8%, liquid paraffin 10.5%, glycerin 7.5%, propylene glycol 10.5%, sodium lauryl sulfate 1.5%, azone 0.6%, ethylparaben 0.12%, and the balance is water.

[0042] The preparation method of above-mentioned propranolol hydrochloride cream, comprises the following steps:

[0043] 1) Mix stearyl alcohol, glyceryl monostearate, stearic acid, and liquid paraffin, heat to melt, dissolve in water and control the temperature at 80°C to obtain an oil phase;

[0044] 2) Boil part of the water and mix it with ethylparaben, stir until completely dissolved, add the remaining water, glycerin, propylene glycol, lauryl sulfate, azone, propranolol hydrochloride, control the temperature of the water bath at 80°C, and obtain water Mutually;

[0045] 3) Add th...

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Abstract

The invention discloses a propranolol hydrochloride cream used for treating infantile hemangioma, and a preparation method thereof. The cream comprises the components of, by weight, 0.8-1.2% of propranolol hydrochloride, 5.5-8% of octadecanol, 5.5-8% of glycerol monostearate, 5.5-8% of stearic acid, 7.5-10.5% of liquid paraffin, 7.5-10.5% of glycerol, 7.5-10.5% of propylene glycol, 1.5-2.5% of an emulsifier, 0.4-0.6% of a penetration enhancer, 0.08-0.12% of a preservative, and balance of water. The propranolol hydrochloride cream provided by the invention has good stability, and an effective duration of at least 24 months. The cream can directly act upon an infection site, such that local medicine concentration is high, and adverse reactions caused by oral administration or intravenous administration can be avoided. With the cream, medicine effect can be maximized, and medicine side effect can be reduced. The cream has a definite effect, and is suitable for industrialized large-scale productions. The cream is used for treating hemangioma and is especially suitable for treating infantile hemangioma.

Description

technical field [0001] The invention relates to a propranolol hydrochloride cream for treating infantile hemangioma and a preparation method thereof. Background technique [0002] Infantile hemangioma (infantile hemangioma) is a congenital dysplasia that occurs during the formation of blood vessels in the embryonic period. It is more common at birth or shortly after birth. It is the most common benign tumor in infants and young children. 85-90% of hemangiomas can regress spontaneously without special treatment, but some hemangiomas may be life-threatening, affect body function or damage appearance, and require active treatment. Treatment methods include surgical resection, cryotherapy, radiation and radionuclide therapy, laser therapy, drug therapy, etc. Drug therapy is the most commonly used treatment. Traditional treatment drugs include glucocorticoids, interferon, antineoplastic drugs, etc. The above drugs have their own advantages and disadvantages, but all have differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/138A61P35/00A61P9/00
Inventor 程飚袁进
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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