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Polylactic acid material modified by self assembly of beta-glucanase and sulfated chitosan and preparation thereof

A chitosan sulfate, polylactic acid material technology, applied in the direction of coating, can solve the problems of lack of bioactive groups, poor biocompatibility, single structural properties, etc., to improve biocompatibility and surface The effect of biological properties

Inactive Publication Date: 2013-04-24
王辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to being biodegradable, products made of polylactic acid have good biocompatibility, gloss, transparency, feel and heat resistance, but it also has a single structure and performance, high brittleness, hydrophilicity and thermal stability. disadvantages, and the lack of biologically active groups, so its poor compatibility with organisms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 A polylactic acid material modified by self-assembly of β-glucanase and chitosan sulfate

[0025] (1) Preparation of PLA membrane

[0026] Dissolve polylactic acid in dichloromethane at a mass volume ratio of 8g:50mL, and stir to obtain a polylactic acid solution after it is completely dissolved, cast it in a film casting tray, and evaporate the solvent to obtain a polylactic acid film. The film was stirred and washed in ethanol aqueous solution for 1 hour, and then vacuum-dried at 40°C for 12 hours to obtain the finished product;

[0027] (2) Surface amination of PLA membranes

[0028] Put the polylactic acid film in (2) into 60mL, 0.1g / mL isopropanol solution containing ethylenediamine, and stir at 45°C for 5min to obtain a polylactic acid film with amino functionalities on the surface, and then use a large amount of Rinse with distilled water, then soak with 0.012mol / L hydrochloric acid for 15 minutes, and wash with distilled water again to obtain a polyl...

Embodiment 2

[0038] Example 2 A polylactic acid material modified by self-assembly of β-glucanase and chitosan sulfate

[0039] (1) Preparation of PLA membrane

[0040] Dissolve polylactic acid in dichloromethane at a mass-volume ratio of 10g: 80mL. After stirring to dissolve completely, a polylactic acid solution is obtained, which is cast in a film casting tray, and the solvent is evaporated to obtain a polylactic acid film. The film was stirred and washed in ethanol aqueous solution for 2 hours, and then vacuum-dried at 40°C for 12 hours to obtain the finished product;

[0041] (2) Surface amination of PLA membranes

[0042] Put the polylactic acid film in (2) into 60mL, 1g / mL isopropanol solution containing ethylenediamine, and stir at 45~50°C for 3~5min to obtain a polylactic acid film with amino functional groups on the surface, Rinse again with a large amount of distilled water, then soak with 0.012mol / L hydrochloric acid for 20 minutes, and wash with distilled water again to obta...

Embodiment 3

[0052] Example 3 A polylactic acid material modified by self-assembly of β-glucanase and chitosan sulfate

[0053] (1) Preparation of PLA membrane

[0054] Dissolve polylactic acid in 70mL of dichloromethane at a mass-volume ratio of 9g, and stir to obtain a polylactic acid solution, cast it on a film casting tray, and evaporate the solvent to obtain a polylactic acid film. The film was stirred and washed in ethanol aqueous solution for 1.5 hours, and then vacuum-dried at 40°C for 12 hours to obtain the finished product;

[0055] (2) Surface amination of PLA membranes

[0056] Put the polylactic acid film in (2) into 0.1g / mL isopropanol solution containing ethylenediamine, and stir at 45-50°C for 3-5min to obtain a polylactic acid film with amino functional groups on the surface, and then Rinse with a large amount of distilled water, then soak with 0.012mol / L hydrochloric acid for 18 minutes, and wash with distilled water again to obtain a polylactic acid film with surface a...

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PUM

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Abstract

The invention discloses a polylactic acid material modified by self assembly of beta-glucanase and sulfated chitosan and a preparation method thereof. Substances used for modification are biological materials with biological activity, and the polylactic acid material is nontoxic and degradable and can be used for a biomedical material for improvement of biocompatibility and surface biological properties of the biomedical material.

Description

technical field [0001] The invention relates to the field of self-assembly materials, in particular to a polylactic acid material self-assembled and modified by β-glucanase and chitosan sulfate and its preparation. Background technique [0002] There is a hydroxyl group and a carboxyl group in a single lactic acid molecule, multiple lactic acid molecules together, -OH dehydration condensation with -COOH of other molecules, -COOH dehydration condensation with -OH of other molecules, in this way, they form hand in hand The polymer is called polylactic acid. Polylactic acid, also known as polylactide, belongs to the family of polyesters. Polylactic acid is a polymer obtained by polymerizing lactic acid as the main raw material. The raw material source is sufficient and can be regenerated. The production process of polylactic acid is non-polluting, and the product can be biodegraded to realize the cycle in nature, so it is an ideal green polymer material. [0003] Polylactic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08J7/12C08J5/18C08L67/04C08B37/08
Inventor 苏建丽
Owner 王辉
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