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Method adopting temperature inductivity characteristic of phase-change high polymer material to prepare biodegradable particles

A polymer material and degradable technology, applied in medical science, surgery, etc., can solve problems such as inability to remove solvents, side effects of products, etc., and achieve the effects of easy mass production, stability and safety guarantee, and simple operation

Inactive Publication Date: 2013-05-01
嘉兴天源药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even by evaporation, the solvent cannot be completely removed, and the residual solvent will cause side effects to the product

Method used

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  • Method adopting temperature inductivity characteristic of phase-change high polymer material to prepare biodegradable particles
  • Method adopting temperature inductivity characteristic of phase-change high polymer material to prepare biodegradable particles
  • Method adopting temperature inductivity characteristic of phase-change high polymer material to prepare biodegradable particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for making biodegradable particles using temperature-sensitive characteristics of phase-change polymer materials, which includes the following steps:

[0035] S1. The biodegradable polymer material is dissolved in an organic solvent to obtain a biodegradable polymer material solution, and the biodegradable polymer material accounts for 4% by weight of the solution; the second copolymer is dissolved in PBS to obtain the first biodegradable polymer material solution. Two copolymer solution, the weight ratio that the second copolymer accounts for the solution is 1.8%; After mixing the biodegradable polymer material solution and the second copolymer solution, use ultrasonic emulsification to form an emulsified solution; the second copolymer is Polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a weight ratio of 69% to 73% of polyoxyethylene, the biodegradable polymer material is polylactic acid (PLLA), the second copolymer The average molecula...

Embodiment 2

[0042] A method for making biodegradable particles using temperature-sensitive characteristics of phase-change polymer materials, which includes the following steps:

[0043] S1. Dissolving the biodegradable polymer material in an organic solvent to obtain a biodegradable polymer material solution, the biodegradable polymer material accounts for 3.8% by weight of the solution; dissolving the second copolymer in PBS to obtain the first Two copolymer solution, the second copolymer accounts for 2% by weight of the solution; the biodegradable polymer material solution is mixed with the second copolymer solution to form an emulsified solution by ultrasonic emulsification; the second copolymer is Polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a weight ratio of 69% to 73% of polyoxyethylene, and the biodegradable polymer material is polylactic acid-glycolic acid (PLGA) 85: 15. The average molecular mass of the second copolymer is 12500-16000 g / mol;

[0044]...

Embodiment 3

[0050] A method for making biodegradable particles using temperature-sensitive characteristics of phase-change polymer materials, which includes the following steps:

[0051] S1. The biodegradable polymer material is dissolved in an organic solvent to obtain a biodegradable polymer material solution, and the biodegradable polymer material accounts for 4.2% by weight of the solution; the second copolymer is dissolved in PBS to obtain the first biodegradable polymer material solution. Two copolymer solutions, the second copolymer accounted for 2.3% by weight of the solution; the biodegradable polymer material solution was mixed with the second copolymer solution to form an emulsified solution by ultrasonic emulsification; the second copolymer was Polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a weight ratio of 69% to 73% of polyoxyethylene, and the biodegradable polymer material is polylactic acid-glycolic acid (PLGA) 85: 15. The average molecular mass ...

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Abstract

The invention discloses a method adopting the temperature inductivity characteristic of phase-change high polymer material to prepare biodegradable particles, which includes the following steps: S1, dissolving biodegradable high polymer material in an organic solvent, dissolving a second copolymer in PBS, and forming emulsifying solution through ultrasonic emulsification after the solutions are mixed; S2, dissolving a first copolymer in water, and adding the emulsifying solution; S3, transferring the mixed liquid to a thermostatic bath, stirring, and vacuumizing at the arranged temperature of 30-40 DEG C; S4, adding ultrapure water at the set temperature of 4-15 DEG C; S5, cleaning particles, and performing freeze drying; and S6, sterilizing. The invention has the benefits that the solvent quantity is minimum, the product stability and safety can be further guaranteed; the operation is simple, and particle volume production can be realized more easily; and the prepared product has the characteristics of biocompatibility, biodegradability, porosity and the like, the mechanical strength of particles is excellent, and the sizes of particles are adjustable.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a method for making biodegradable particles by utilizing the temperature-sensitive characteristics of phase-change polymer materials. Background technique [0002] Due to trauma, congenital diseases, cancer, infection, inflammation and other reasons, tissue and organ defects are increasing. At present, autologous, allogeneic or xenogeneic tissues and organs are usually used for clinical transplantation and repair, but there are still insufficient supply sources. , causing damage to the donor and immune rejection and other problems, it is difficult to meet the clinical needs. [0003] Urinary incontinence is the phenomenon of involuntary leakage of urine regardless of time and place. Urinary incontinence can be divided into five categories: overflow incontinence, mixed incontinence, functional incontinence, urge incontinence and stress incontinence, of which stress incontinence a...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08L71/02C08L67/04A61L31/06A61L31/14
Inventor 朱雪标金相镇杜彦军崔明
Owner 嘉兴天源药业有限公司
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