The invention belongs to a filling material used for fixing equipments, and especially relates to a room-temperature-cured epoxy resin cast cushion block and a preparation method thereof. According to existing technologies, the fixation of machineries with relatively large weights requires a large amount of bolts, such that the operation is difficult; in an environment with severe corrosion, fixing bolts are likely to be corroded, and the strengths of the bolts are reduced. The a room-temperature-cured epoxy resin cast cushion block provided by the invention is composed of, by weight: 100 parts of epoxy resin, 0 to 20 parts of a toughening agent, 0 to 3 parts of a diluent, 50 to 100 parts of active silicon micro-powder, 5 to 25 parts of an active crystal whisker material, 0 to 3 parts of titanium dioxide, 0 to 3 parts of a pigment, 0 to 1 part of an antifoaming agent, and 5 to 15 parts of a curing agent. The invention is advantaged in that: the surface properties of the product provided by the invention are stable, the product is not easy to contract, and the service life of the product is long. The cushion block can be cured under room temperature, such that the preparation method is simple. With the cushion block, the equipment can be firmly fixed, and requirements under vessel rocking and corrosion conditions can be satisfied.