Lipid emulsion of magnolol and preparation method thereof

A fat emulsion and honokiol technology, applied in the field of medicine, can solve the problems of poor water solubility of honokiol, etc., and achieve the effects of high drug loading, scientific formulation and good stability

Inactive Publication Date: 2013-05-08
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For above-mentioned situation, in order to solve the defect of prior art, the purpose of the present invention is exactly to provide a kind of fat emulsion of magnolol and preparation method thereof, can effectively solve the problem of magnolol water-soluble difference

Method used

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  • Lipid emulsion of magnolol and preparation method thereof
  • Lipid emulsion of magnolol and preparation method thereof
  • Lipid emulsion of magnolol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 5g of soybean oil, 5g of medium chain triglyceride, 500mg of magnolol, 0.2g of oleic acid, and 0.05g of vitamin E, and stir continuously for 5min under the ultrasonic condition of 53KHz water bath to dissolve to obtain the oil phase, and keep it warm at 60°C for later use ; Separately weigh 1 g of soybean lecithin, 2 g of polyoxyethylene (40) hydrogenated castor oil, and 2.5 g of glycerin, add water for injection to 100 ml, and stir continuously for 6 min under 70KHz water bath ultrasonic conditions to dissolve, obtain the water phase, and keep warm at 60°C for later use , slowly drop the oil phase into the water phase, stir while adding, homogenize at a homogenization speed of 21500rpm for 6 minutes to obtain colostrum, then use a microfluidizer to perform high-pressure homogenization of the colostrum, and cycle 5 times at a pressure of 13Kpsi , then circulated 10 times under 18Kpsi pressure, and finally adjusted the pH value of the final milk to 7.68 with 0.1...

Embodiment 2

[0025]Weigh 5g of soybean oil, 5g of medium-chain triglyceride, 500mg of magnolol, 0.1g of oleic acid, and 0.05g of vitamin E, and stir continuously for 5min under 60KHz water-bath ultrasonic conditions to dissolve to obtain the oil phase, and keep it warm at 65°C for use ; Separately weigh 1.8g of soybean lecithin, 1.2g of poloxamer 407, and 2.25g of glycerin, add water for injection to 100ml, and stir continuously for 9min under the condition of 60KHz water-bath ultrasonic to dissolve to obtain the water phase, and keep it warm at 65°C Standby; slowly add the water phase to the oil phase, stir while adding, homogenize at a homogenization speed of 24000rpm for 7 minutes to obtain colostrum, then use a microfluidizer to perform high-pressure homogenization of the colostrum, and circulate under a pressure of 18Kpsi 12 times, and finally use 0.1mol / L or 2mol / L sodium hydroxide solution to adjust the pH value of the final milk to 7.83 to obtain the final milk, filter the final mil...

Embodiment 3

[0027] Weigh 5g of camellia oil, 5g of medium-chain triglyceride, 450mg of magnolol, 0.05g of oleic acid, and 0.05g of vitamin E, and stir continuously for 4min under the ultrasonic condition of 53KHz water bath to dissolve to obtain the oil phase, keep warm at 65°C for later use ; Separately weigh 1.8g of soybean lecithin, 1.2g of poloxamer 407, and 1.5g of glucose, add water for injection to 100ml, and stir continuously for 10min to dissolve under 53KHz water-bath ultrasonic conditions to obtain an aqueous phase, which is kept at 65°C for later use; Slowly add the oil phase to the water phase, stir while adding, and homogenize the colostrum at a homogenization speed of 24,000 rpm for 5 minutes to obtain colostrum, then use a microfluidizer to perform high-pressure homogenization of the colostrum, and circulate 15 times under a pressure of 18Kpsi, and finally Use 0.1mol / L or 2mol / L sodium hydroxide solution to adjust the pH value to 8.53 to obtain the final milk, filter th...

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Abstract

The invention relates to a lipid emulsion of magnolol and a preparation method thereof. According to the lipid emulsion of the magnolol and the preparation method thereof, the problem of poor water-solubility of the magnolol can be effectively solved. The following technical proposal is that the lipid emulsion of the magnolol is prepared from the following raw materials by weight percentage: 0.01%-5% of magnolol, 2-30% of oil for injection, 0.1-20% of an emulsifier, 1-10% of an isoosmotic adjusting agent, 0.001-1% of a stabilizer, 0.001-3% of an antioxidant, 0.00001-0.5% of a pH regulator and the balance of water for injection. The lipid emulsion of the magnolol, provided by the invention, is scientific in formulation, simple in formula, reliable in quality, good in stability, high in drug loading capacity, stable in long-term storage and good in safety, thus being a great innovation on the pharmaceutic preparation.

Description

technical field [0001] The invention relates to medicine, in particular to a fat emulsion of magnolol and a preparation method thereof. Background technique [0002] Magnolia is the main active ingredient isolated from Magnolia officinalis Magnolia. It is a biphenol compound with an allyl group. Modern pharmacological research results show that magnolol has anti-tumor, cardio-cerebral Vascular protection, muscle relaxation, anti-inflammation, antibacterial, anti-oxidation, anti-pathogenic microorganisms, anti-ulcer, antagonizing calmodulin, nourishing nerves, preventing aging and other pharmacological effects, and has small toxic and side effects. It is a very promising natural medicinal ingredients. [0003] However, the water solubility of magnolol is extremely poor, and it is difficult to make a liquid preparation with stable physical and chemical properties, which greatly limits its clinical application. At present, the preparations of magnolol in the literature main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/05A61K47/44A61K47/34A61P1/00A61P9/00A61P25/00A61P35/00
Inventor 王艳芝郑甲信赵媛媛李强
Owner ZHENGZHOU UNIV
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