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Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage

A composition and acute stage technology, applied in the field of traditional Chinese medicine, can solve problems such as poor dissolution of active ingredients of Danshen and unrecorded other uses of traditional Chinese medicine compositions, so as to prevent brain neuron damage, reduce degradation loss, and have high content of active ingredients Effect

Inactive Publication Date: 2013-05-08
SHANDONG PHOENIX PHARM CO LTD
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

[0002] Chinese patent CN200310114532.X discloses a traditional Chinese medicine composition for treating acute cerebral infarction and early recovery and its preparation method. This patent was declared by our company in 2003 and obtained the invention patent certificate in 2006. Our company applies this patented technology The produced Tiandan Tongluo Capsules have a good effect in clinical use, but part or all of the salvia miltiorrhiza in it is extracted with ethanol and used as medicine in the form of an extract. Practice has proved that the effective ingredients of the salvia miltiorrhiza are not well dissolved; at the same time Leeches are extracted from water and used as an extract
Moreover, other applications of the Chinese medicine composition have not been recorded in other documents disclosed at present.

Method used

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  • Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage
  • Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage
  • Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh the following compositions according to the following weight ratios: 12% Chuanxiong Rhizoma, 14% Siberian Radix, 13% Salvia Miltiorrhiza, 3% Leech, 14% Gastrodia elata, 9% Sophora japonica, 9% Shichangpu, 0.3% Artificial Bezoar, and 17% Radix Astragali. %, Achyranthes bidentata 8.7%.

[0021] Prepare the Chinese medicine composition according to the following steps:

[0022] (1) Grind the dried leech into primary powder with an ordinary pulverizer, and then pulverize the primary powder into ultrafine powder with ultrafine pulverization equipment, and the particle size range of ultrafine powder is 5-45 μm;

[0023] (2) After crushing Salvia miltiorrhiza (through a 50-60 mesh sieve), use ethanol (95%) 4 times its mass and purified water to carry out CO 2 Supercritical extraction to obtain tanshinone active substances and purified total salvianolic acid, keep the extraction pressure at 25Mpa-35Mpa, the extraction temperature at 60-70°C, and the extraction time for 4...

Embodiment 2

[0028] Weigh the following compositions according to the following weight ratios: Rhizoma Chuanxiong 14%, Jucao 14%, Salvia miltiorrhiza 14%, Leech 5%, Gastrodia elata 14%, Sophora japonica 9%, Shichangpu 7.5%, Artificial bezoar 0.5%, Astragalus 15% , Achyranthes bidentata 7%. The preparation steps are the same as in Example 1.

Embodiment 3

[0030] The following compositions were weighed according to the following weight ratios: Rhizoma Chuanxiong 14%, Jucao 12.5%, Salvia miltiorrhiza 14%, Hirudo 5%, Gastrodia elata 12%, Sophora japonica 7%, Shichangpu 9%, Artificial bezoar 0.5%, Astragalus 17% , Achyranthes knee 9%. The preparation steps are the same as in Example 1.

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Abstract

The invention relates to the technical field of traditional Chinese medicines and in particular relates to a novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage. The production process is improved on the basis of the original prescription of Chinese patent CN200310114532.X, the leeches are subjected to superfine grinding, the salvia miltiorrhiza is totally subjected to CO2 supercritical extraction, and the medicinal compositions in the medicinal materials are effectively kept through the process. Compared with clinical research, the clinical curative effect of the product subjected to process improvement on stroke (cerebral thrombosis) is obviously superior to the curative effect of the original process product; and moreover, the prepared traditional Chinese medicine composition has the effects of resisting oxidation and eliminating radicals and has a positive effect of preventing brain neuron injuries, and according to the pharmacodynamics study, the traditional Chinese medicine composition has an obvious curative effect on aged dementia (AD).

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a new preparation method and application of a traditional Chinese medicine composition for treating cerebral infarction in the acute stage and early recovery stage. Background technique [0002] Chinese patent CN200310114532.X discloses a traditional Chinese medicine composition for treating acute cerebral infarction and early recovery and its preparation method. This patent was declared by our company in 2003 and obtained the invention patent certificate in 2006. Our company applies this patented technology The produced Tiandan Tongluo Capsules have a good effect in clinical use, but part or all of the salvia miltiorrhiza in it is extracted with ethanol and used as medicine in the form of an extract. Practice has proved that the effective ingredients of the salvia miltiorrhiza are not well dissolved; at the same time Leeches are extracted from water and used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P9/10A61P25/28A61K35/62A61K35/413
Inventor 徐云亭李玉生陈敏华商桂春聂伟张学涛
Owner SHANDONG PHOENIX PHARM CO LTD
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