Composite membrane for guiding bone tissue regeneration and preparation method thereof

Abstract

The invention discloses a composite membrane for guiding bone tissue regeneration and a preparation method thereof. The composite membrane comprises a basal layer, an intermediate modified layer and a functional surface layer, wherein the basal layer is a poly lactic-co-glycolic acid (PLGA) membrane, the intermediate modified layer is formed by polymerizing dopamine to form polydopamine and adsorbing the polydopamine to the surface of the PLGA membrane, and the functional surface layer is formed by reaction of I-type collagen or a collagen / chitosan mixture and active groups in the polydopamine. The preparation method for the composite membrane comprises a series of steps of membrane preparation, rinsing, airing and the like. The artificially synthesized macromolecular polymer is used as a basal material, the surface of the membrane obtained after the basal material is grafted with a natural polymer to undergo surface function activation and functional modification has a nano structure and active groups which are not owned by the original synthesized polymer, the affinity of osteoblasts is improved, and adhesion and proliferation of cells are promoted; and by using the synthesized macromolecular polymer as the base, high mechanical strength and controllable degradability are provided, and the grafted natural polymer is combined with the base firmly by pre-modification of the surface of the synthesized macromolecular polymer.

Description

technical field [0001] The invention relates to the field of polymer biomedical materials, in particular to a surface-functionalized composite film for guiding bone tissue regeneration and a preparation method thereof. Background technique [0002] The concept of guided tissue regeneration (guided tissue regeneration, GTR) was first proposed by Nyman et al. It refers to relying on mechanical barriers to selectively guide cells to attach and proliferate to damaged parts to achieve the purpose of tissue repair. Guided tissue regeneration is a theory and technology to promote tissue regenerative healing developed on the basis of in vitro, in vivo and clinical experimental research in the 1980s. Therefore, as a new material with the function of guiding tissue regeneration, the medical guided tissue regeneration material will play a great role in clinical medicine, and its development and research are attracting great attention from the material and medical circles. [0003] Me...

AI Technical Summary

Problems solved by technology

In the late 1970s and early 1980s, Nyman, Gottlow and Becket et al successively conducted research on non-degradable materials such as polyacetal, polytetrafluoroethylene (PTFE), and silicone membranes. Biocompatibility, but because it cannot be absorbed by the tissue, a second operation is required to remove the material, which increases the chance of trauma, is difficult to be accepted by patients, and the clinical effect is not very satisfactory.

Synthetic polymers generally have excellent mechanical properties and long degradation time, but insufficient biological activity; natural polymers often have better biological activity and can promote cell adhesion and proliferation, but often lack mechanical strength and degrade too fast