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Levocarnitine tablets and preparation method thereof

A technology of L-carnitine tablet and ethanol solution, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Fewer types of excipients, solving insufficient hardness and reliable product quality

Active Publication Date: 2013-06-12
GUANGDONG XIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem of insufficient hardness of the whole powder compressed tablet and the similarity between the in vitro release and the original preparation; to obtain the levocarnitine tablet prescription and preparation process with reliable product quality and suitable for industrial production

Method used

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  • Levocarnitine tablets and preparation method thereof
  • Levocarnitine tablets and preparation method thereof
  • Levocarnitine tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 490g of levocarnitine, 380g of microcrystalline cellulose, and 30g of povidone, pass through 20 sieves, and mix evenly; 90g of 75% ethanol solution is used to make soft materials and granulate; dry at 55±5°C; add the dried granules to 10g of magnesium stearate, mixed uniformly. Measure the water content and content, calculate the tablet weight according to the content data and the labeled amount, and press the tablet; measure the weight difference of the pressed tablet, related substances; pack, and get the finished product.

Embodiment 2

[0027] Weigh 470g of levocarnitine, 350g of microcrystalline cellulose, and 20g of povidone, pass through 20 sieves, and mix evenly; 80g of 65% ethanol solution is used to make soft materials and granulate; dry at 55±5°C; add the dried granules to 30g of magnesium stearate, mixed uniformly. Measure the water content and content, calculate the tablet weight according to the content data and the labeled amount, and press the tablet; measure the weight difference of the pressed tablet, related substances; pack, and get the finished product.

Embodiment 3

[0029] Weigh 550g of levocarnitine, 400g of microcrystalline cellulose, and 50g of povidone, pass through 20 sieves, and mix evenly; make soft material with 100g of 80% ethanol solution, and granulate; dry at 55±5°C; add the dried granules to 10g of magnesium stearate, mixed uniformly. Measure the water content and content, calculate the tablet weight according to the content data and the labeled amount, and press the tablet; measure the weight difference of the pressed tablet, related substances; pack, and get the finished product.

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Abstract

The invention discloses levocarnitine tablets and a preparation technique thereof. Levocarnitine is used as a raw material, microcrystalline cellulose is used as a filler, povidone K30 is used as a binding agent, magnesium stearate is used as a lubricant, and ethanol is used as a wetting agent; and tabletting is carried out after wet-process granulation to solve the problem of insufficient hardness in all powder tabletting. The raw material does not need to be pulverized or screened, the variety and consumption of the auxiliary materials are small, and the technique is simple and easy to implement and suitable for mass production.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a levocarnitine tablet and a preparation method thereof. Background technique: [0002] Levocarnitine is also known as vitamin BT, L-carnitine. In terms of pharmacological research: L-carnitine is an essential substance in the energy metabolism of mammals, and plays an important role in the production and transportation of energy in cells. It can bring long-chain fatty acids into mitochondria to promote their oxidative decomposition and provide energy for cells. Fatty acids in skeletal muscle and cardiac muscle are the main energy metabolites. L-carnitine plays an essential role in the energy metabolism of skeletal muscle and cardiac muscle. effect. During ischemia and hypoxia, fatty acyl-CoA accumulates, long-chain fatty acylcarnitine in mitochondria also accumulates, and free carnitine decreases due to massive consumption. Ischemia and hypoxia lead ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/205A61K47/38A61P3/04A61P3/00A61P9/04A61P9/06A61P9/10A61P9/02A61P3/06A61P21/02A61P15/08
Inventor 陈超张志生孙晔杜丽丽王学文付培荣黄彩逢
Owner GUANGDONG XIANQIANG PHARMA