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Compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection and preparation method thereof

A compound preparation, the technology of pleuropneumonia, is applied in the directions of anti-inflammatory agents, respiratory diseases, non-central analgesics, etc., which can solve problems such as difficulty in controlling the disease and curing, economic losses for farmers, and untimely treatment, and achieve blood medicine. The effect of long-term concentration maintenance, strong drug penetration and strong killing ability

Active Publication Date: 2013-06-12
湖南尚成生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Porcine infectious pleuropneumonia is often associated with one or more of other respiratory diseases such as swine panting disease, haemophilus parasuis disease, pasteurellosis, reproductive and respiratory syndrome, bordetella bronchiseptica, streptococcal disease, etc. Mixed infections lead to complicated conditions and difficult diagnosis. If the treatment is not timely, the mortality rate will be higher
General drugs or unilateral drugs are difficult to control and cure the disease, causing serious economic losses to farmers

Method used

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  • Compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The compound preparation of this example contains the following components in the following amounts: 10 g of florfenicol, 5 g of azithromycin, 2.5 g of sodium diclofenac, 3 g of trimethoprim, 30 g of dimethylformamide, 1 g of polyvinylpyrrolidone, a- 14 g of pyrrolidone, 20 g of propylene glycol, 0.04 g of dexamethasone, and absolute ethanol were added to 100 ml.

[0031] The preparation method comprises the following steps:

[0032] (1) Mix 20 g of dimethylformamide and 10 g of propylene glycol, add polyvinylpyrrolidone and a-pyrrolidone, heat to 50 °C, add florfenicol, azithromycin, and sodium diclofenac in turn, and stir until dissolved to obtain A liquid;

[0033] (2) Take 10 g of dimethylformamide, 10 g of propylene glycol and 10 g of absolute ethanol to form a composite solvent, heat to 80°C, add trimethoprim and stir until dissolved to obtain liquid B;

[0034] (3) Combine liquid A and liquid B, add dexamethasone pre-dissolved in 3 ml of absolute ethanol, add a...

Embodiment 2

[0036] The compound preparation of this example comprises the following components: 20 g of florfenicol, 10 g of azithromycin, 5 g of sodium diclofenac, 6 g of trimethoprim, 30 g of dimethylformamide, 2 g of polyvinylpyrrolidone, α-pyrrolidone 13g, 20g of propylene glycol, 0.08g of dexamethasone, and absolute ethanol were added to 100ml.

[0037] The preparation method comprises the following steps:

[0038] (1) Mix 20 g of dimethylformamide and 10 g of propylene glycol, add polyvinylpyrrolidone and a-pyrrolidone, heat to 55°C, add florfenicol, azithromycin, and sodium diclofenac in turn, stir until dissolved to obtain A liquid;

[0039] (2) Take 10 g of dimethylformamide, 10 g of propylene glycol and 10 g of absolute ethanol to form a composite solvent, heat to 70°C, add trimethoprim and stir until dissolved to obtain liquid B;

[0040] (3) Combine liquid A and liquid B, add dexamethasone pre-dissolved in 4 ml of absolute ethanol, add absolute ethanol to 100 ml, filter, fil...

Embodiment 3

[0042] The compound preparation of this example contains the following components in the amounts: 10 g of florfenicol, 5 g of azithromycin, 4 g of aminopyrine, 3 g of trimethoprim, 30 g of dimethylformamide, 1 g of polyvinylpyrrolidone, 1 g of N-methyl- 15 g of 2-pyrrolidone, 20 g of propylene glycol, 0.04 g of dexamethasone, and absolute ethanol were added to 100 ml.

[0043] The preparation method comprises the following steps:

[0044] (1) Mix 20 g of dimethylformamide and 10 g of propylene glycol, add polyvinylpyrrolidone and N-methyl-2-pyrrolidone, heat to 60°C, add florfenicol, azithromycin, and aminopyrine in sequence, and stir until Dissolved to get A liquid;

[0045] (2) Take 10 g of dimethylformamide, 10 g of propylene glycol and 10 g of absolute ethanol to form a composite solvent, heat to 60°C, add trimethoprim and stir until dissolved to obtain liquid B;

[0046] (3) Combine liquid A and liquid B, add dexamethasone pre-dissolved with 2 ml of absolute ethanol, ad...

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Abstract

The invention relates to a compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection; the preparation comprises the following components in dose: each 100ml compound preparation contains 5-20g of florfenicol, 3-10g of azithromycin, 2-6g of antisepsis synergist, 2-8g of antipyretic analgesic anti-inflammatory agent, 0.03-0.08g of glucocorticoid, 8-18g of stabilizer and the balance of organic solvent. The invention further provides a preparation method of the compound preparation. In the compound preparation, the antibacterial medicines and the symptomatic treatment medicines, which are highly sensitive to bacteria, are used and are compounded on the basis of treating both symptoms and root causes, therefore the compound preparation has excellent curative effect on porcine contagious pleuropneumonia and respiratory tract mixed infection diseases, is wide in antibacterial spectrum and high in cure rate, and is long-acting, efficient and stable.

Description

technical field [0001] The invention relates to the field of veterinary pharmaceutical preparations, in particular to a compound preparation for treating porcine infectious pleuropneumonia and mixed infection of the respiratory tract and a preparation method thereof. Background technique [0002] Porcine infectious pleuropneumonia is a swine respiratory infectious disease caused by Actinobacillus pleuropneumoniae, and it is also one of the five major infectious diseases that is recognized internationally as one of the five major infectious diseases that endanger the modern swine industry. Clinically, it is characterized by acute sepsis, fever, cough, and high degree of dyspnea. The necropsy lesions are characterized by bilateral pleuropneumonia and hemorrhagic and necrotizing pneumonia. Acute morbidity and death often occur, the morbidity rate can reach 80%-100%, and the mortality rate is generally more than 50%. [0003] Porcine infectious pleuropneumonia is often associat...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/7052A61K9/08A61P11/00A61P31/04A61P29/00A61K31/165A61K31/573A61K31/505A61K31/4152A61K31/196
Inventor 熊以宓曹典军谭武贵
Owner 湖南尚成生物科技有限公司
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