Method for rapidly and efficiently preparing aucubin monomer from eucommia ulmoides

An aucubin, fast technology, applied in the field of medicine, can solve the problems of cumbersome operation, large consumption of reagents, high cost, etc., and achieve the effect of broad development prospects, simple environmental protection process, and low equipment requirements
CN103172684AInactive Publication Date: 2013-06-26JISHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JISHOU UNIVERSITY
Publication Date
2013-06-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for rapidly and efficiently preparing an aucubin monomer from eucommia ulmoides. The method disclosed by the invention comprises the following steps of: taking eucommia ulmoides leaves / peels / seed cakes as raw materials; adding methanol or ethyl acetate according to a certain ratio to carry out ultrasonic reflowing and extraction; filtering; decompressing a filtering solution and recycling a solvent to a suitable amount; after cooling, separating light brown sediment; adding suitable amounts of ethyl acetate-methanol; condensing and reflowing; hotly filtering; standing at a room temperature; and separating sediments and filtering to obtain a white grain crystal of aucubin. The method disclosed by the invention adopts abundant raw material resources and the aucubin monomer can be prepared by two steps of extracting and crystallizing; and the method has an environment-friendly and simple process, is low in equipment requirements and can easily realize industrialized production. The industrial production of the aucubin enhances development and utilization values of the eucommia ulmoides in fields of medical treatment and health care, and brings about economic and social benefits.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a method for rapidly and efficiently preparing aucubin monomer from Eucommia ulmoides. Background technique

[0002] Aucubin (AU) is an iridoid compound with the molecular formula C 15 h 22 o 9 . The molecular weight is 346.33. It is white needle-like crystal in ethanol. The melting point is 181°C. It is easily soluble in polar solvents such as water, methanol and ethanol, and almost insoluble in weak polar solvents such as petroleum ether, chloroform and ether. The molecule of aucubin contains hemiacetal structure, which is active and easy to decompose when encountering acid, alkali, heat, light, oxygen, etc. Scholars at home and abroad have found that aucubin and its derivatives have liver protection and detoxification, anti-inflammatory, anti-oxidation, anti-aging, anti-osteoporosis and other effects.

[0003] Eucommia ( Eucommia ulmoides Oliv) is a perennia...

Claims

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