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Nabumetone spraying agent and preparation method

A nabumetone and spray technology, applied in the field of nabumetone spray and its preparation, can solve the problems of failing to improve the skin penetration rate of the drug, the skin penetration amount cannot meet the treatment requirements, and increase the bioavailability , Overcome the large first-pass effect of the liver and improve the skin permeability

Active Publication Date: 2015-07-15
NEW FOUNDER HLDG DEV LLC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the barrier function of the stratum corneum of human skin, the skin penetration of many drugs cannot meet the purpose of treatment
At present, scientific and technological literature " preparation technology " (the 8th phase of volume 9 in 2000) discloses a kind of preparation method of nabumetone liniment and quality control thereof, yet, this method only dissolves medicine simply, fails to improve Skin Penetration of Drugs

Method used

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  • Nabumetone spraying agent and preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0044]Take 1.0g of nabumetone, dissolve it in a mixed solution of 45g of 95% ethanol and 5g of polyethylene glycol 400, add 1.0g of azone, mix well, then fill it into a 60ml spray bottle, and the packaging is complete . Each bottle contains 1.0g nabumetone, which can be used 100 times.

Embodiment 2

[0046] Take 2.0g of nabumetone, dissolve it in a mixed solution of 40g of 95% ethanol and 10g of polyethylene glycol 400, add 2.0g of azone, mix well, then fill it into a 60ml spray bottle, and the packaging is complete . Each bottle contains 2.0g nabumetone, which can be used 100 times.

Embodiment 3

[0048] Take 3.0g of nabumetone, dissolve it in a mixed solution of 30g of 95% ethanol and 20g of polyethylene glycol 400, add 1.0g of azone, mix well, then fill it into a 60ml spray bottle, and the packaging is complete . Each bottle contains 3.0g nabumetone, which can be used 100 times.

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Abstract

The invention relates to a nabumetone spraying agent and a preparation method. The nabumetone spraying agent comprises nabumetone, a transdermal penetrating agent and an excipient. The nabumetone spraying has the advantages of fast absorption, safe drug usage and convenient usage, can avoid large liver first-pass effect of a nabumetone oral preparation, and can avoid the stimulation generated by continuous administration for gastrointestinal tract.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to nabumetone spray and a preparation method thereof. Background technique [0002] Nabumetone (also known as nabumetone, nabumetone), chemically named 4-(6-methoxy-2-naphthyl)-butan-2-one, is a non-acidic Steroidal anti-inflammatory drug, first listed in 1985 (trade name: Relifex, BRL-14777). The drug has good anti-inflammatory activity and medium-strength analgesic and antipyretic effects, with little toxic and side effects and good tolerance, and can be used for various types of rheumatoid arthritis, tendonitis, cervical spondylitis, soft tissue rheumatism diseases, and the pain caused by these diseases; it can also be used for sports soft tissue injuries, sprains and contusions, etc., and the pain and inflammation caused by these conditions. It is favored by patients and physicians due to its unique pharmacological properties. [0003] The existing dosage forms on the mark...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/12A61K47/10A61K47/22A61K47/12A61P29/00
Inventor 戴宏保周键赵德贺清凯
Owner NEW FOUNDER HLDG DEV LLC
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