Method for preparing amino acid N-carboxyanhydride

Abstract

The invention provides a method for preparing amino acid N-carboxyanhydride. The method includes enabling amino acid to react with triphosgene to generate the corresponding amino acid N-carboxyanhydride in the presence of triphosgene decomposition catalysts under the condition that anhydrous tetrahydrofuran is used as a solvent. The method has the advantages that the triphosgene decomposition catalysts are utilized and are beneficial to increasing the decomposition rate of the triphosgene, accordingly, the reaction time is shortened, the yield of the amino acid-NCA (N-carboxyanhydride) is increased, and the reaction yield is particularly greatly increased when R-groups of the amino acid are short.

Description

technical field [0001] The invention relates to a method for preparing an acid anhydride in an amino acid N-carboxyl ring. Background technique [0002] Chemically synthesized polyamino acids or peptides are a class of biopolymer materials with structures similar to natural proteins or peptides. The polyamino acid obtained by homopolymerization or copolymerization of amino acid not only has excellent mechanical properties, but also has low toxicity, good biocompatibility and biodegradability. Therefore, polyamino acid exhibits better performance than ordinary natural fibers and chemical fibers, and is widely used in various fields such as industry, agriculture, and medicine, especially in the field of biomedical materials, showing unique medicinal value. Among the many methods for synthesizing polyamino acids at present, the ring-opening polymerization using amino acid N-Carboxy Anhydride (NCA for short) has become the most important way to prepare polyamino acids. After W...

AI Technical Summary

Problems solved by technology

[0007] Although the most commonly used method in the industry is to use triphosgene instead of phosgene and amino acids to prepare amino acid-NCA, because triphosgene needs to be decomposed into phosgene before the condensation reaction in the ring, and then reacted with amino acids to obtain the corresponding products, So its yield is lower than when phosgene reacts with amino acids

In addition, when the R group in the amino acid molecule is shorter, the yield decreases more obviously

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