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Novel application of phloroglucinol

A technology of phloroglucinol, medicine, applied in the field of phloroglucinol, new medical use, can solve the problem of no mention of respiratory system treatment, prevention or relief, no phloroglucinol treatment, relief or prevention of bronchial asthma And other issues

Inactive Publication Date: 2013-07-24
上海市闸北区市北医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, there is no report about phloroglucinol being used to treat, relieve or prevent respiratory diseases such as bronchial asthma and chronic cough, and the instructions of phloroglucinol commercial products do not mention that the medicine has therapeutic, Preventive or palliative effect

Method used

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  • Novel application of phloroglucinol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Oral Freeze-dried Tablets of Phloroglucinol

[0017] The phloroglucinol oral freeze-dried tablet is composed of an aqueous solution of phloroglucinol (20% by weight), glycerin (35% by weight), lactose (30% by weight), and carboxymethylcellulose (15% by weight) It is prepared by adopting the preparation method of conventional drug oral freeze-dried tablets to make about 100 mg tablets each, and the content of phloroglucinol in each tablet is about 20 mg.

Embodiment 2

[0018] Example 2 Preparation of Phloroglucinol Injection

[0019] Phloroglucinol injection consists of phloroglucinol 10g, trimethylphloroglucinol 0.1g, sodium chloride 0.1g, sodium bisulfite 0.05g, citric acid 0.05g, disodium hydrogen phosphate dodecahydrate 0.1 g and 1L of water for injection are prepared, and the preparation method of conventional drug injection is adopted to make an injection with a phloroglucinol content of about 10 mg / mL.

Embodiment 3

[0020] Example 3 Preparation of phloroglucinol freeze-dried powder injection

[0021] The phloroglucinol freeze-dried powder injection is mainly made of phloroglucinol and mannitol, and the preparation method of the conventional drug freeze-dried powder injection is adopted, and the phloroglucinol content in the freeze-dried powder injection is about 50% by weight.

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Abstract

The invention discloses a novel application of phloroglucinol, namely an application of phloroglucinol in preparing medicaments for treating bronchial asthma or chronic cough. The new application provides a new treatment way for patients with bronchial asthma and chronic cough; the phloroglucinol is used for relieving or treating the bronchial asthma and chronic cough diseases and obviously improving the cough, expectoration and asthma symptoms of the patients, has the advantages of no toxic and side effects, good treatment effect and the like, and is easily accepted by the patients.

Description

Technical field [0001] The present invention involves the field of pharmaceutical technology. Specifically, it is a new medical use in the preparation or the treatment of bronchial asthma and chronic cough diseases to prepare or treat bronchial asthma. Background technique [0002] PHLOROGLUCINOL (commodity: Spafeng) directly acts on the flat muscle of the gastrointestinal tract and urogenicic tract.Acute spasm pain caused by obstacles; acute spasm urethral, bladder, renal colic; gynecological spasm pain.Compared with other smooth muscle solving drugs, its characteristics are not anti -choline. While lifting smooth muscle spasm, it will not produce a series of anti -choline -like side effects, which will not cause symptoms such as hypotension, heart rate, arrhythmia and other symptoms.There is no effect on cardiovascular function.Animal pharmacological test shows that it only acts on spasm and smooth muscles, which has a small impact on normal flat muscle.Various toxic test resul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P11/06A61P11/14
Inventor 王瑾
Owner 上海市闸北区市北医院
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