Method for preparing bacterial cellulose slow-release analgesia dressing

A technology of bacterial cellulose and bacterial cellulose film, which is applied in the field of preparation of bacterial cellulose sustained-release analgesic dressings, can solve the problems of skin irritation and low efficiency of dressing administration, and achieve skin trauma relief and slow-release analgesia drug effect

Active Publication Date: 2013-07-24
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional dressings have low drug delivery efficiency, require frequent dressing changes, and are irritating to the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Bacterial cellulose is soaked in 1% by weight sodium hydroxide aqueous solution, and the carboxymethyl cellulose aqueous solution containing 4% by weight of carboxymethyl cellulose is evenly dropped on the surface of the bacterial cellulose membrane On the surface, a bacterial cellulose membrane modified by carboxymethyl cellulose was obtained.

[0021] (2) Uniformly disperse the analgesic drug fentanyl in the chitosan solution to obtain solution A, wherein the molecular weight of chitosan is 50,000, and the chitosan is dissolved in 3% by weight of acetic acid aqueous solution to prepare a weight percent 0.5% chitosan acetate solution. Mix liquid paraffin and Span 60 to obtain solution B, wherein the volume of surfactant accounts for 0.1% of the volume of solution B. In a water bath at 35°C, solution B was slowly added dropwise to solution A, and a stable water-in-oil (W / O) emulsion was obtained by high-speed stirring. The emulsion was washed and separated in a qu...

Embodiment 2

[0024] (1) Soak the bacterial cellulose in 5% by weight sodium hydroxide aqueous solution, and evenly drop the carboxymethyl cellulose aqueous solution containing 0.1% by weight of carboxymethyl cellulose on the bacterial cellulose membrane On the upper surface, a bacterial cellulose membrane modified by carboxymethyl cellulose was obtained.

[0025] (2) Uniformly disperse the analgesic drug remifentanil in the chitosan solution to obtain solution A, wherein the molecular weight of chitosan is 150,000, and the chitosan is dissolved in 1% by weight aqueous acetic acid solution to prepare a weight The percentage is 2% chitosan acetate solution. Mineral oil was mixed with Span 65 to obtain solution B, wherein the volume of surfactant accounted for 2% of the volume of solution B. In a water bath at 50°C, solution B was slowly added dropwise into solution A, and a stable water-in-oil (W / O) emulsion was obtained by high-speed stirring. The emulsion was washed and separated in a quen...

Embodiment 3

[0028] (1) Soak the bacterial cellulose in 3% by weight sodium hydroxide aqueous solution, and evenly drop the carboxymethyl cellulose aqueous solution containing 1% by weight of carboxymethyl cellulose on the surface of the bacterial cellulose membrane On the upper surface, a bacterial cellulose membrane modified by carboxymethyl cellulose was obtained.

[0029] (2) Uniformly disperse the analgesic drug sufentanil in chitosan acetic acid solution to obtain solution A, wherein chitosan molecular weight is 300,000, and chitosan is dissolved in 0.1% by weight aqueous acetic acid solution to prepare The weight percent is 5% chitosan acetic acid solution. Vegetable oil is mixed with propylene glycol fatty acid ester to obtain solution B, wherein the volume of surfactant accounts for 3% of the volume of solution B. In a water bath at 70°C, solution B was slowly added dropwise to solution A, and a stable water-in-oil (W / O) emulsion was obtained by high-speed stirring. The emulsion...

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PUM

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Abstract

The invention discloses a method for preparing a bacterial cellulose slow-release analgesia dressing and relates to the technical field of medical apparatus and instruments and preparation thereof. The method comprises the following steps: uniformly dispersing analgesics in a chitosan solution to obtain a solution A, and mixing an organic solution and a surfactant to obtain a solution B; slowly dropping the solution B into the solution A in a water bath, and performing high-speed stirring to obtain stable water-in-oil (W / O) emulsion; washing the emulsion in a shock chilling water bath, and separating to obtain chitosan slow-release microspheres which have uniform particle size and are encapsulated with the analgesics; and uniformly dripping the chitosan slow-release microspheres on a bacterial cellulose film modified by carboxymethyl cellulose, and performing freeze drying to obtain the bacterial cellulose slow-release analgesia dressing. The method is simple and feasible in preparation process, convenient in operation and low in cost; and the prepared slow-release dressing has the multiple effects of slowly releasing the analgesics, sterilizing, moisturizing, ventilating, absorbing wound exudate and the like and can relieve skin injury and postoperative incisional pain and cure various skin wounds.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a preparation method of bacterial cellulose sustained-release analgesic dressing. Background technique [0002] Traditional dressings have low drug delivery efficiency, require frequent dressing changes, and are irritating to the skin. In order to improve the efficacy of drugs, reduce adverse reactions and the number of administrations, and meet the requirements of high efficiency, long-term effect, and low toxic and side effects, drug sustained-release dressings can be used. Sustained drug release is the combination (or compounding, encapsulation) of drug active molecules with polymer carriers, and then administered into the biologically active body through diffusion, penetration and other control methods, and then the drug active molecules are released at an appropriate concentration and duration. So as to achieve the purpose of giving full play t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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