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External preparation for skin moistening

A technology for external preparations and preparations, applied in skin diseases, drug combinations, etc., can solve problems such as unsatisfactory water retention effects, and achieve the effects of promoting further proliferation, increasing expression, and improving efficacy

Inactive Publication Date: 2013-08-14
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to modern Chinese medicinal chemistry research, the polysaccharide molecular weight range of Dendrobium candidum is 15.7kDa~157kDa, therefore, the polysaccharide isolated from Dendrobium candidum is indiscriminately made into emollient preparations, obviously the water retention effect is not ideal

Method used

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Examples

Experimental program
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example 1

[0019] Example 1 (preparation of Dendrobium officinale polysaccharide with a molecular weight of 85-90kDa)

[0020] 1.1 Extraction of Dendrobium officinale total polysaccharides

[0021] 1. Water extraction and alcohol precipitation extraction method

[0022] The dried stem of Dendrobium candidum is crushed and passed through 50 meshes to obtain Dendrobium candidum powder; water 50 times the powder mass is added to the Dendrobium candidum powder, decocted and extracted twice, each time for 2 hours; the two extracts are combined and concentrated to the original One-tenth of the volume, add 4 times the volume of ethanol with a volume concentration of 95% to the concentrated solution, let it stand overnight, centrifuge, remove the lower layer of sediment, freeze-dry and fully dissolve with an appropriate amount of water, add Sevage reagent to remove protein 6 times, each time adding half volume of Sevage reagent of the solution, shaking well, standing for 30min to separate the l...

example 2

[0039] Example 2 (Preparation of Dendrobium candidum polysaccharide emollient preparation with active ingredients molecular weight of 85-90kDa)

[0040] Moisturizer

[0041] 1. Formulation:

[0042] Dendrobium officinale polysaccharide: adopt nano-Si0 in the example 1 2 - Polyvinylidene fluoride composite membrane separation of 0.01g polysaccharides of Dendrobium officinale with a molecular weight of 85-90kDa

[0043] Oil phase: simethicone 2.5g, liquid paraffin 3.5g, white oil 4g;

[0044] Water phase: carbomer ultra-1019.6g, glycerin 2g, PEG-4002g;

[0045] Antibacterial agent: clove oil 0.2g;

[0046] Emulsifier: Lecithin 2g.

[0047] 2. Preparation method: After the Dendrobium candidum polysaccharide is added to the water phase, the water phase and the oil phase are heated in a water bath at 60°C respectively. After mixing well, the water phase is slowly poured into the oil phase. Adjust pH to 6.5-7.5 with 18% NaOH, add water to 100g to constant volume. Stir and coo...

example 3

[0062] Example 3 (the effect of emollient preparations made of polysaccharides of Dendrobium officinale with different molecular weights as active ingredients on skin water retention)

[0063] 3.1 Experimental materials

[0064] Experimental preparation: the moisturizer cream, moisturizer and moisturizer prepared in Example 2.

[0065] Experimental animals: The experimental animals were New Zealand rabbits weighing 2.2-2.5kg, a total of 78, half male and half male.

[0066] Experimental equipment: high-precision skin moisture tester (GL-IV).

[0067] 3.2 Preparation of Control Emollient Preparation

[0068] Moisturizer

[0069] Adopt nano-Si0 in the example 1 2 - Dendrobium officinale polysaccharide samples A1, C1, and D1 with molecular weights of 95.3-157kDa, 35.3-74.4kDa, and 15.7-20kDa separated by polyvinylidene fluoride composite membrane were prepared into three kinds of comparisons according to the preparation method of the moisturizing cream sample in Example 2 Pr...

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Abstract

The invention relates to an external preparation for skin moistening. The preparation is formed by an effective component and medically acceptable auxiliary materials, and is characterized in that the effective component is dendrobium officinale polysaccharide with the molecular weight of 85-90 KDa. The external preparation for skin moistening disclosed by the invention can increase the expression quantity of a skin aquaporins-3 gene so as to accelerate further multiplication of malpighian cells and obviously improve a skin water retention effect.

Description

technical field [0001] The invention relates to a medical preparation of undetermined structure from plants of the genus Dendrobium, in particular to an external preparation of Dendrobium officinale polysaccharide. technical background [0002] Dendrobium officinale Kimura et Migo is a medicinal plant of the genus Dendrobium officinale. Modern research has proved that Dendrobium officinale has the functions of enhancing immune function, promoting digestion, protecting liver and gallbladder, anti-rheumatism, lowering blood sugar and blood lipids, anti-tumor, protecting eyesight, nourishing skin and anti-aging. [0003] Dendrobium officinale polysaccharide is a kind of active polysaccharide, which is a main component in Dendrobium officinale. Modern medical research shows that Dendrobium officinale polysaccharides have the functions and effects of immune regulation, anti-tumor, anti-gene mutation, lowering blood pressure, lowering blood fat, lowering blood sugar, virus, anti-...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P17/16
Inventor 魏小勇陈丹戚辉
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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