Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet

A technology of Periplaneta americana and gastric floating tablets, applied in the new field of medicine, can solve problems such as increasing the risk of duodenal and gastric ulcers

Inactive Publication Date: 2013-08-14
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Infection with Helicobacter pylori can lead to chronic gastritis and gastric...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Composition formula:

[0026] Periplaneta americana powder 30g

[0027] Hydroxypropyl methylcellulose E4M 15g

[0028] Stearyl alcohol 15g

[0029] Mannitol 34g

[0030] Sodium Bicarbonate 5g

[0031] Micro Powder Silica 1g

[0032] 100 pieces

[0033] 2. Preparation method:

[0034] The American cockroach powder, hydroxypropyl methylcellulose, stearyl alcohol, sodium bicarbonate, mannitol, and micropowder silica gel were respectively sieved through an 80-mesh sieve, and then used for later use; the hydroxypropyl methylcellulose E4M was dried at 50 ° C for 24 hours, pass through an 80-mesh sieve and set aside.

[0035] The American cockroach powder, hydroxypropyl methylcellulose, stearyl alcohol, sodium bicarbonate, mannitol, micropowder silica gel and hydroxypropyl methylcellulose E4M obtained above are mixed uniformly, and then the above-mentioned powder is directly compressed into Tablets, and the hardness is controlled at 2-10 kg to obtain Periplaneta...

Embodiment 2

[0041] 1. Composition formula:

[0042] Periplaneta americana extract 5g

[0043] Chitosan 5g

[0044] Hydroxypropyl methylcellulose K15M 12.5g

[0045] Cetyl Alcohol 10g

[0046] Sodium Lauryl Sulfate 2g

[0047] Magnesium Carbonate 5.5g

[0048] Lactose 59g

[0049] Magnesium Stearate 1g

[0050] 100 pieces

[0051] 2. Preparation method:

[0052] Pass chitosan, hydroxypropyl methylcellulose K15M, cetyl alcohol, sodium lauryl sulfate, magnesium carbonate, and lactose through an 80-mesh sieve for use; dry hydroxypropyl methylcellulose K15M at 60°C for 24 Hours, pass through a 100-mesh sieve and set aside.

[0053] The chitosan prepared above, hydroxypropyl methylcellulose K15M, cetyl alcohol, sodium lauryl sulfate, magnesium carbonate, lactose and hydroxypropyl methylcellulose are uniformly mixed to obtain a mixture.

[0054] Add the Periplaneta americana extract to the above mixture to make soft materials, then pass through a 20-mesh sieve to granulate, then ...

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PUM

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Abstract

The invention provides an intragastric floating tablet for periplaneta americana. The intragastric floating tablet is a tablet prepared from periplaneta americana powder or periplaneta americana extracting solution as an active ingredient and an auxiliary material, wherein the weight ratio of the active ingredient to the auxiliary material is 1:(1-30), preferably 1:(2-20), and more preferably 1:19. The intragastric tablet can stay longer in stomach, can well treat helicobacter pylori infection gastritis, peptic ulcer and gastric cancer, and has a wide market prospect.

Description

technical field [0001] The invention belongs to the field of new pharmaceutical technology, and relates to a new dosage form, in particular to a preparation method and application of a gastric floating tablet. Background technique [0002] The American cockroach is native to South America and is the largest insect in the cockroach family. Adults are 29-35 mm long, reddish-brown, with wings longer than the end of the abdomen. The antennae are very long, there are large butterfly-shaped brown stripes in the middle of the pronotum, and the trailing edge of the stripes has a complete yellow stripe. The components of Periplaneta americana can activate blood and dissipate blood stasis, detoxify and eliminate chancre, diuresis and reduce swelling. Under normal circumstances, the stomach wall has a series of perfect self-protection mechanisms, which can resist the invasion of thousands of microorganisms that enter by mouth. Studies have shown that Helicobacter pylori has a strong...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/22A61P1/04A61P35/00
Inventor 耿福能曹嘉
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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