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Electrostatic spinning preparation method for hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal

A nanofiber membrane, metal magnesium technology, applied in textiles, papermaking, non-woven fabrics, etc., can solve the problems of weakened tissue functionality, degradation rate hindering the synthesis of new tissue, etc., and achieve novel operation, good application prospects, and simple methods. Effect

Inactive Publication Date: 2013-08-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because in terms of the relationship between the two, if the degradation rate is too fast, the tissue functionality will be weakened; on the contrary, if the degradation rate is too low, the synthesis of new tissue will be hindered

Method used

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  • Electrostatic spinning preparation method for hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal
  • Electrostatic spinning preparation method for hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal
  • Electrostatic spinning preparation method for hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 0.4 g of P(LLA-CL) with an electronic analytical balance and dissolve it in 5 ml of hexafluoroisopropanol to obtain a P(LLA-CL) solution with a concentration of 8% (g / ml); weigh it with an electronic analytical balance 0.2 grams of magnesium powder, dissolved in 8% (g / ml) P(LLA-CL) solution, magnetically stirred at room temperature until completely dissolved (the mass ratio of P(LLA-CL) to magnesium powder in the solution is 2:1 ); after dissolving, the solution is an electrospinning solution, the voltage is 16 kV, the advancing speed of the syringe is 1.0 ml / hour, and the receiving distance is 15 cm. The No. 9 needle is selected and accepted by aluminum foil paper to obtain a P( LLA-CL) and metal magnesium powder nano-hybrid fiber membrane.

Embodiment 2

[0021] Weigh 0.4 g of P(LLA-CL) with an electronic analytical balance and dissolve it in 5 ml of hexafluoroisopropanol to obtain a P(LLA-CL) solution with a concentration of 8% (g / ml); weigh it with an electronic analytical balance 0.1 gram of magnesium powder, dissolved in 8% (g / ml) P(LLA-CL) solution, magnetically stirred at room temperature until completely dissolved (the mass ratio of P(LLA-CL) to magnesium powder in the solution is 4:1 ); after dissolving, the solution is an electrospinning solution, the voltage is 14 kV, the advancing speed of the syringe is 1.5 ml / hour, and the receiving distance is 15 cm. The No. 9 needle is selected and accepted by aluminum foil paper to obtain a P( LLA-CL) and metal magnesium powder nano-hybrid fiber membrane.

Embodiment 3

[0023] Weigh 0.4 g of P(LLA-CL) with an electronic analytical balance and dissolve it in 5 ml of hexafluoroisopropanol to obtain a P(LLA-CL) solution with a concentration of 8% (g / ml); weigh it with an electronic analytical balance 0.045 grams of magnesium powder, dissolved in 8% (g / ml) P(LLA-CL) solution, magnetically stirred at room temperature until completely dissolved (the mass ratio of P(LLA-CL) to magnesium powder in the solution is 9:1 ); after dissolving, the solution is an electrospinning solution, the voltage is 20 kV, the advancing speed of the syringe is 0.5 ml / hour, and the receiving distance is 20 cm. The No. 9 needle is selected and accepted by aluminum foil to obtain a P( LLA-CL) and metal magnesium powder nano-hybrid fiber membrane.

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Abstract

The invention relates to an electrostatic spinning preparation method for a hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal. The method comprises the steps of adding magnesium powder into a lactate caprolactone copolymer P(LLA-CL) solution, dissolving to obtain an electro-spinning solution, and conducting electrostatic spinning, so that the hybrid nanofiber membrane containing P(LLA-CL) and magnesium metal is obtained, and the mass ratio of the P(LLA-CL) to the magnesium metal is (2-10):1. The method is simple, efficient, novel, convenient to operate and good in application prospect; and according to the method, the nanofiber membrane is prepared through electro-spinning of the mixed solution of the P(LLA-CL) and the magnesium powder, and the method is applicable to simulation of fiber degradation performance analysis inside bodies of organisms.

Description

technical field [0001] The invention belongs to the field of preparation of nanofiber membranes, in particular to an electrospinning preparation method of nanofiber membranes mixed with P(LLA-CL) and metal magnesium. Background technique [0002] Damage and loss of human tissue can lead to dysfunction. The traditional repair method is autologous tissue transplantation, although satisfactory curative effect can be achieved, but it is at the expense of autologous healthy tissue, which will cause many complications and additional damage; human organ failure, drug treatment, temporary Alternative therapy can save the lives of some patients, but the sources of donor organs are extremely limited, and immunosuppressive agents need to be used for a long time due to immune rejection, and the resulting complications are sometimes fatal. Since scientists first proposed the concept of "tissue engineering" in the 1980s, it has brought hope to the treatment of many tissue defects and org...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382
Inventor 莫秀梅李赫宇
Owner DONGHUA UNIV
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