Applications of MEN1 gene and encoding protein thereof

Abstract

The invention relates to the field of medicine biology, wherein a liver-specific MEN1 gene knocked out mouse model is established to research effects of menin in liver cells, and results show that MEN1 gene provides important effects in EMT inhibition (epithelial-mesenchymal transition of liver cells) and glycolipid metabolism regulation. In addition, the MEN1 gene can be adopted for preparing and screening anti-hepatic fibrosis and anti-fatty liver drugs so as to provide valuable clues and directions for clinical targeted therapy.

Description

technical field [0001] The invention belongs to the field of medical biology, and relates to the application of MEN1 gene and its coded protein in the preparation and screening of drugs for treating liver fibrosis and fatty liver. Background technique [0002] In 1997, Chandrasekharappa et al. first identified and cloned a new tumor suppressor gene, MEN1, in the third band (11q13) of the long arm of human chromosome 11. The protein menin encoded by this gene is an endocrine tumor suppressor factor present in various tissues and cells. Its deletion or mutation induces a relatively rare autosomal dominant genetic disorder, multiple endocrine neoplasia type 1, which causes a variety of endocrine neoplasms including parathyroid tumors, pancreatic islet cell tumors, and pituitary tumors2 . At present, thousands of MEN1 gene mutation sites have been identified, all over the coding region and promoter of MEN1 gene, resulting in loss of protein expression or translation errors, re...

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Problems solved by technology

At present, thousands of MEN1 gene mutation sites have been identified, all over the coding region and promoter of the MEN1 gene, resulting in loss of protein expression or translation errors, resulting in the loss of the tumor suppressor function of menin and the occurrence of tumors

However, the structure of menin is relatively special, and n

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