Cefradine capsules and preparation method thereof

A technology of cephradine and capsules, which is applied in the field of cephradine capsules and its preparation, can solve the problems of easy hydrolysis of cephradine, and achieve the effects of rapid dissolution, good stability and simple preparation process

Active Publication Date: 2013-08-28
SHANGHAI MEIYOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the deficiencies in the prior art, the inventor intends to fundamentally solve the problem that cephradine is easily hydrolyzed

Method used

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  • Cefradine capsules and preparation method thereof
  • Cefradine capsules and preparation method thereof
  • Cefradine capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 cephradine capsules

[0020]

[0021]

[0022] Preparation Process

[0023] Cephradine is passed through a 100-mesh sieve, added to the prescribed amount of Span 80, stirred evenly, added with calcium hydrogen phosphate passed through an 80-mesh sieve for adsorption, and finally mixed with micronized silica gel, and filled into capsules.

Embodiment 2

[0024] The preparation of embodiment 2 cephradine capsules

[0025]

[0026] Preparation Process

[0027] Cephradine is passed through a 120-mesh sieve, added to the prescription amount of Span 85, stirred evenly, added calcium hydrogen phosphate and calcium carbonate passed through an 80-mesh sieve for adsorption, finally mixed with talcum powder, and filled into capsules.

Embodiment 3

[0028] The preparation of embodiment 3 cephradine capsules

[0029]

[0030] Preparation Process

[0031] Cephradine is passed through a 100-mesh sieve, added to the prescribed amount of Span 80, stirred evenly, added with calcium sulfate passed through an 80-mesh sieve for adsorption, and finally mixed with micronized silica gel, and filled into capsules.

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Abstract

The invention discloses cefradine capsules and a preparation method thereof. The capsules consist of filler and capsule shells, wherein the filler is obtained by mixing medicament-containing fine powder and a lubricating agent uniformly, and the medicament-containing fine powder is prepared from cefradine, Span and neutral inorganic salt. The preparation method comprises the following steps of: adding the cefradine into the Span, stirring uniformly, then adding the inorganic salt, performing adsorption to obtain the medicament-containing fine powder, mixing the medicament-containing fine powder and the lubricating agent, and filling the capsule shells with the mixture. The capsules have the advantages of high stability and quick dissolution, meanwhile, the preparation method is simple and meets the requirement of mass production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cephradine capsule and a preparation method thereof. Background technique [0002] Cephradine (Cephradine, Velosef), aliased as cephalosporin VI, cephalosporin VI, etc., is the first generation of semi-synthetic cephalosporins, and its antibacterial effect is similar to that of cephalexin. This product is acid-resistant and can be taken orally, with good absorption and high blood concentration. It is characterized by resistance to β-lactamase, and has rapid and reliable bactericidal effect on drug-resistant Staphylococcus aureus and other bacilli resistant to broad-spectrum antibiotics. , It is mainly excreted in the urine in the original form, and the concentration in the urine is relatively high. It is mainly used clinically for infections of the respiratory tract, urinary tract, skin and soft tissues, such as bronchitis, pneumonia, pyelonephritis, cystitis, ear...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61K47/22A61P31/04
CPCY02A50/30
Inventor 不公告发明人
Owner SHANGHAI MEIYOU PHARMA
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