Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation

A technology of temperature-sensitive gel for ulcerative colitis, applied in the field of preparation of temperature-sensitive gel of total alkaloids of Sophora sophorae, to achieve the effects of not easy to flow out of the cavity, high bioavailability, and convenient use

Active Publication Date: 2013-09-04
江苏加南美地生物科技有限公司
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of Sophora alopecia total alkaloids thermosensitive gel in the treatment of ulcerative colitis and various gynecological inflammations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation
  • Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation
  • Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Sophora Sophora Total Alkali Thermosensitive Gel (Specification: 5.0%: 10g)

[0058] Sophora Sophora Total Alkaloids 50.0g

[0059] Poloxamer 188 200.0g

[0060] Poloxamer 407 600.0g

[0061] Propylene glycol 10.0g

[0062] Benzalkonium Bromide 5.0g

[0063] pH buffer solution Appropriate amount.

[0064] Made of 100

[0065] Dissolve the prescribed amount of poloxamer 188 and poloxamer 407 in a small amount of purified water, place at low temperature (0-4°C) until completely dissolved, then add the total alkaloids of Sophora sophorae into the above solution, and stir until mixed evenly . Then add humectant propylene glycol and preservative benzalkonium bromide, and finally add appropriate pH buffer solution to the full amount according to the site of administration, stir and mix well. Phase transition temperature measurement experiments show that the gel phase transition temperature is 30-35°C. The pH of the buffer solution for rect...

Embodiment 2

[0066] Example 2 Sophora Sophora Total Alkali Thermosensitive Gel (Specification: 30.0%: 10g)

[0067] Sophora Sophora Total Alkali 300.0g

[0068] Poloxamer 188 100.0g

[0069] Poloxamer 407 400.0g

[0070] Propylene glycol 20.0g

[0071] Benzalkonium Bromide 5.0g

[0072] pH buffer solution Appropriate amount.

[0073] Made of 100

[0074] Dissolve the prescribed amount of poloxamer 188 and poloxamer 407 in a small amount of purified water, place at low temperature (0-4°C) until completely dissolved, then add the total alkaloids of Sophora sophorae into the above solution, and stir until mixed evenly . Then add humectant propylene glycol and preservative benzalkonium bromide, and finally add appropriate pH buffer solution to the full amount according to the site of administration, stir and mix well. Phase transition temperature measurement experiments show that the gel phase transition temperature is 30-35°C. The pH of the buffer solution for rectal...

Embodiment 3

[0075] Example 3 Sophora Sophora Total Alkali Thermosensitive Gel (Specification: 10.0%: 10g)

[0076] Sophora Sophora Total Alkalinity 100.0g

[0077] Poloxamer 188 200.0g

[0078] Poloxamer 407 500.0g

[0079] Propylene glycol 10.0g

[0080] Benzalkonium Bromide 5.0g

[0081] pH buffer solution Appropriate amount.

[0082] Made of 100

[0083] Dissolve the prescribed amount of poloxamer 188 and poloxamer 407 in a small amount of purified water, place at a low temperature (0-4°C) until completely dissolved, then add the total alkaloids of Sophora sophorae into the above solution, and stir until mixed evenly . Then add humectant propylene glycol and preservative benzalkonium bromide, and finally add appropriate pH buffer solution to the full amount according to the site of administration, stir and mix well. Phase transition temperature measurement experiments show that the gel phase transition temperature is 30-32°C. The pH of the buffer solution for...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
phase transition temperatureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation. The temperature-sensitive gel is prepared from the following raw and auxiliary materials in percentage by weight: 5-30% of sophora alopecuroides total alkaloid, 50-80% of matrix, 0.5-10% of a moisturizing agent, 0.5-10% of a preservative and the balance of a pH buffer solution. The anti-inflammatory and antiviral medicine sophora alopecuroides total alkaloid is firstly prepared into the temperature-sensitive gel, the temperature sensitivity of a high polymer material is utilized, and the medicine is administrated in a liquid state, adhered with tract surfaces and forms a semi-solid state gel in a proper temperature so as to play a treatment role. The preparation is administrated in the liquid state and disperses uniformly in tracts, and the contact area of the preparation and tissues is increased, so that the bioavailability can be improved, and a purpose of improving a curative effect is realized. Moreover, the preparation forms the semi-solid state gel in a proper temperature, cannot easily flows out of the tracts, slightly contaminates clothes, is convenient to use and can strength the patient compliance.

Description

technical field [0001] The invention relates to a preparation method and application of a temperature-sensitive polymer material gel, in particular to a preparation method and application of a Sophora sophorae total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC), also known as chronic nonspecific ulcerative colitis, is a relatively common digestive system disease and a chronic inflammatory disease of the rectum and colon of unknown cause. The lesions are mostly located in the sigmoid colon and rectum, and can also extend to the descending colon, or even the entire colon. Clinical symptoms mainly include: diarrhea, abdominal pain, mucus pus and blood in the stool or pus and blood in the stool, etc. At present, clinical non-surgical treatment includes oral administration, intravenous administration and retention enema. Oral drugs mainly include sulfas...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/06A61P1/00A61P15/00A61P15/02
Inventor 武新安张建强张建萍魏玉辉周燕段好刚
Owner 江苏加南美地生物科技有限公司