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Synthetic method of polyhydroxybutyrate-artemisia sphoerocephala polysaccharide copolymer

A technology of polyhydroxybutyrate and polyhydroxybutyrate diol, which is applied in the synthesis field of polyhydroxybutyrate-artemisia polysaccharide copolymer, can solve the problem of restricting the development and application of PHB, high price of PHB and easy decomposition and other problems, to achieve the effect of improving hydrophilicity, low cost, and simple preparation method

Active Publication Date: 2013-09-04
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high price of PHB, poor toughness, and easy decomposition during processing, the development and application of PHB are severely limited.

Method used

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  • Synthetic method of polyhydroxybutyrate-artemisia sphoerocephala polysaccharide copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Synthesis of polyhydroxybutyrate diol macromonomer: Weigh 15g of polyhydroxybutyrate and dissolve in 150mL of chloroform, reflux and stir at 65°C for 30 min; add 5g of anhydrous p-toluenesulfonic acid and then add 30mL Ethylene glycol, in N 2 React under protection for 10 hours, add distilled water to stir and wash 6 times, then suction filter at 0.06MPa, and freeze-dry the obtained solid at -60°C and 2Pa for 24 hours to obtain polyhydroxybutyrate diol macromonomer;

[0026] (2) Synthesis of macromonomer isocyanate: Weigh 2g polyhydroxybutyrate diol macromonomer and dissolve in 50mL dichloroethane, reflux and stir at 60°C for 20 minutes, add 0.5mL toluene diisocyanate dropwise with a constant pressure funnel (dropped in 30 minutes), add 0.2mL stannous octoate, N 2 Protection, stirring and reacting at 60°C for 12 hours to obtain macromonomer isocyanate;

[0027] (3) Preparation of Artemisia polysaccharide solution: Weigh 0.4g Artemisia polysaccharides at room tempe...

Embodiment 2

[0030] (1) Synthesis of polyhydroxybutyrate diol macromonomer: Weigh 10g polyhydroxybutyrate and dissolve in 150mL chloroform, reflux and stir at 75°C for 20 min; add 4g of anhydrous p-toluenesulfonic acid and then add 50mL ethylene glycol, N 2 React under protection for 12 hours, add distilled water, stir and wash 8 times, filter under the condition of 0.08MPa, and freeze-dry the obtained solid at -55°C and 1Pa for 28 hours to obtain polyhydroxybutyrate diol macromonomer;

[0031] (2) Synthesis of macromonomer isocyanate: Weigh 3g polyhydroxybutyrate diol macromonomer and dissolve it in 50mL dichloroethane, reflux and stir at 50°C for 40 minutes, add 0.3mL toluene diisocyanate dropwise with a constant pressure funnel (40 minutes drop), add 0.15mL stannous octoate, N 2 Protection, stirring and reacting at 50°C for 14 hours to obtain macromonomer isocyanate;

[0032] (3) Preparation of Artemisia argyi polysaccharide solution: Weigh 0.6g Artemisia annua polysaccharide at room ...

Embodiment 3

[0035] (1) Synthesis of polyhydroxybutyrate diol macromonomer: Weigh 12g of polyhydroxybutyrate and dissolve it in 150mL of chloroform, stir at reflux at 60°C for 35 min, add 4g of anhydrous p-toluenesulfonic acid and then add 30mL ethylene glycol, N 2 React under protection for 11 hours; add distilled water, stir and wash 4 times, suction filter under the condition of 0.07MPa, and freeze-dry the obtained solid at -50°C and 3Pa for 36 hours to obtain polyhydroxybutyrate diol macromonomer;

[0036] (2) Synthesis of macromonomer isocyanate: Weigh 2g polyhydroxybutyrate diol macromonomer and dissolve it in 50mL dichloroethane, reflux and stir at 65°C for 30 minutes, add 0.4mL toluene diisocyanate dropwise with a constant pressure funnel (35 minutes drop), add 0.1mL stannous octoate, N 2 protection, stirring and reacting at 50°C for 13 hours to obtain a macromonomer isocyanate;

[0037] (3) Preparation of Artemisia argyi polysaccharide solution: Weigh 0.3g Artemisia annua polysa...

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Abstract

The invention discloses a synthetic method of polyhydroxybutyrate-artemisia sphoerocephala polysaccharide copolymer, and belongs to the field of biomaterials and tissue engineering materials. The method comprises the steps that through a coupling agent reaction, polyhydroxybutyrate macromonomer and artemisia sphoerocephala polysaccharide are subjected to coupling to prepare copolymer, so that performances of polyhydroxybutyrate macromonomer and artemisia sphoerocephala polysaccharide are complementary, hydrophilia of the copolymer is improved, and the application range of polyhydroxybutyrate serving as a drug carrier and a tissue engineering material is widened. The synthetic method disclosed by the invention has a simple structure, requires no special equipment, and is simple, controllable, low in cost and suitable for popularization and application.

Description

technical field [0001] The invention belongs to the field of biological materials and tissue engineering materials, and relates to a method for preparing a polyhydroxybutyrate-biological polysaccharide copolymer used as a drug carrier or tissue engineering material, in particular to a polyhydroxybutyrate-artemisia rubrum Synthetic method of polysaccharide copolymer. technical background [0002] Poly(3-hydroxybutyrate) (PHB) is a thermoplastic polyester plastic synthesized by bacterial fermentation. Compared with the current general-purpose plastics, PHB has good biocompatibility and biodegradability, and its mechanical properties are comparable to those of Similar to polypropylene, it also has special properties such as optical activity, piezoelectricity, and air tightness. As a medical material, packaging material, optical material, etc., PHB can partially replace general-purpose plastics and has been widely used in many aspects. However, the development and application ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G63/91C08G18/42C08B37/00
Inventor 王俊龙赵煜婷赵伟伟赵保堂姚健张继
Owner NORTHWEST NORMAL UNIVERSITY