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Synthesis method of water-soluble derivative of lanthanide series metal loaded carbon nano material and application of water-soluble derivative

A carbon nanomaterial and lanthanide metal technology, which is applied in the field of chemistry to achieve the effect of simple preparation method and good use effect

Inactive Publication Date: 2013-09-18
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a synthetic method and application of a lanthanide metal-loaded carbon nanomaterial water-soluble derivative, which can effectively solve the problem of water-soluble derivatives of the lanthanide metal-loaded carbon nanotubes. Preparation of Derivatives and Problems of Magnetic Resonance Contrast Agents for Tumor Treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation method of the present invention can be realized by the following steps in concrete implementation:

[0019] 1) Add 40mg of carbon nanotubes or graphene oxide into 40mL of mixed acid, add 4mL of hydrogen peroxide as an oxidant, and after ultrasonic reaction for 1 hour at a power of 300-400W, remove the liquid by suction filtration to obtain the filtrate, wash the filtrate until neutral, and obtain Carbon nanotubes or graphene oxide carboxylation products;

[0020] 2) Mix 50mg of carbon nanotubes or graphene oxide carboxylation products with 20mL of ethylenediamine and 1g of N,N'-dicyclohexylcarbodiimide, after ultrasonic dispersion, heat to 120°C and stir at 100r / min Reflux reaction for 48 hours, after the reaction is completed, filter with suction to obtain the filtrate, wash the filtrate with an organic solvent absolute ethanol until neutral, and dry it in vacuum at 40-80°C for 24-56 hours to obtain carbon nanotubes or graphene oxide amination products ...

Embodiment 2

[0023] The preparation method of the present invention can also be realized by the following steps in specific implementation:

[0024] 1) Add 35 mg of carbon nanotubes to 35 mL of mixed acid, add 3.5 mL of hydrogen peroxide as an oxidant, and after ultrasonic reaction at a power of 300-400 W for 1 hour, remove the liquid by suction filtration to obtain filtrate, wash the filtrate with water until neutral, and obtain carbon nanotubes Carboxylation products;

[0025] 2) Mix 45-55mg of carbon nanotube carboxylation product with 18-22mL of 1,3-propylenediamine, 0.9-1.1g of N,N'-dicyclohexylcarbodiimide (DCC), and disperse evenly by ultrasonic, Heat to 120°C, stir and reflux at 100r / min for 48h, after the reaction is completed, filter with suction to obtain the filtrate, wash the filtrate with an organic solvent absolute ethanol until neutral, and dry it in vacuum at 40-80°C for 24-56h to obtain carbon nanotube amination product;

[0026] 3) Take 18 mg of the amination product o...

Embodiment 3

[0028] The preparation method of the present invention can also be realized by the following steps in specific implementation:

[0029] 1) Add 45mg of graphene oxide into 45mL of mixed acid, add 4.5mL of oxidizing agent hydrogen peroxide, and after 1 hour of ultrasonic reaction at a power of 300-400W, remove the liquid by suction filtration to obtain the filtrate, wash the filtrate until neutral, and obtain graphene oxide Carboxylation products;

[0030] 2) Mix 55 mg of graphene oxide carboxylation product with 22 mL of 1,6-hexamethylenediamine and 1.1 g of N,N'-dicyclohexylcarbodiimide (DCC). Stir and reflux at 100r / min for 48 hours. After the reaction is completed, filter with suction to obtain the filtrate. The filtrate is washed with an organic solvent, absolute ethanol until neutral, and dried in vacuum at 40-80°C for 24-56 hours to obtain the graphene oxide amination product ;

[0031] 3) Take 22 mg of the amination product of graphene oxide and put it in 22 mL of mixe...

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PUM

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Abstract

The invention relates to a synthesis method of a water-soluble derivative of a lanthanide series metal loaded carbon nano material and an application of the water-soluble derivative. The synthesis method can be used for effectively solving the problems of preparation of water-soluble derivatives of lanthanide series metal loaded carbon nano tubes and magnetic resonance contrast agents for tumor therapy. The method comprises the following steps of: adding the carbon nano material into mixed acid and hydrogen peroxide, ultrasonically reacting, performing suction filtration, washing the filtered product through water to be neutral, mixing the obtained carbon nano tube carboxylated product with an ammoniation reagent and N,N'-dicyclohexylcarbodiimide, performing ultrasonic dispersion on the mixture, heating, stirring to perform a backflow reaction, performing suction filtration, washing the filtered product through ethanol to be neutral, carrying out vacuum drying on the filtered product, putting the obtained carbon nano material ammoniated product in a mixed solvent, stirring, performing ultrasonic treatment, adding a solution A and a substance B, adding ethanol after a dissolution reaction, performing ultrasonic treatment, performing suction filtration, washing a filter cake through ethanol, adding ethanol, performing ultrasonic treatment, performing suction filtration, washing a filter cake through the solution A, adding the filter cake into ultrapure water, performing ultrasonic treatment, performing suction filtration, washing a filter cake through the ultrapure water, and carrying out vacuum drying to obtain the water-soluble derivative. The preparation method provided by the invention is simple and has a good use effect.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a method for synthesizing water-soluble derivatives of lanthanide metal-loaded carbon nanomaterials and applications thereof. Background technique [0002] In recent years, carbon nanomaterials have been widely used as drug carriers. Among nanomaterials, carbon nanomaterials including fullerenes, carbon nanotubes and graphene oxide have been one of the frontier fields of international science in recent years. Carbon nanotubes (CNTs) have attracted extensive attention from various disciplines due to their unique electrical, mechanical, optical, and thermodynamic properties. Huge specific surface area (~2600m 2 / g), ultra-high mechanical strength, low density, outstanding chemical and thermal stability and electron-rich characteristics, unique transmembrane ability, and large delocalized π bonds, which can form a relatively good relationship with many biomedical molecules. The strong π-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/02B82Y40/00B82Y30/00A61K49/08C01B32/15
Inventor 王蕾史进进张振中刘艳马柔柔张静余晓媛刘瑞瑗高君
Owner ZHENGZHOU UNIV