Compound ofloxacin solution for veterinary use and preparation process of compound ofloxacin solution

Abstract

The invention discloses a compound ofloxacin solution for veterinary use and a preparation process of the compound ofloxacin solution. Each 1L of the compound ofloxacin solution for veterinary use consists of 3-8g of ofloxacin, 1-6g of PVP-K30, 1-6g of chlorhexidine acetate, 0.5-2g of sodium hydrogen sulfite, 10-35g of benzyl alcohol, 0.5-2g of EDTA-2Na, 0.8-2g of Tween-80, 10-200g of propylene glycol, 50-300g of glycerol and injection water for the balance. According to the compound ofloxacin solution, the chlorhexidine acetate is combined with ofloxacin which belongs to quinolone bactericidal medicines, so as to completely develop functional characteristics of the chlorhexidine acetate as a cationic surface active agent, thus changing bacterial membrane permeability, promoting the ofloxacin to enter into bacterium cells, and enhancing the antibacterial function of the ofloxacin; the ofloxacin, chlorhexidine acetate and benzyl alcohol, although are bactericidal medicines, are different in sterilizing mechanism and free from mutual antagonism, so that the bacterium is difficult to generate drug resistance on the three medicines simultaneously; the PVP-K30 can inhibit odor from spreading, and the benzyl alcohol is fragrant, so that the product has a quite strong deodorizing function.

Description

technical field [0001] The invention relates to the technical field of ofloxacin solution, in particular to a veterinary compound ofloxacin solution and a preparation process thereof. Background technique [0002] In the breeding of pets such as cats and dogs, ear diseases such as otitis externa and otitis media and mixed infectious skin diseases have always been a major problem for breeders. These diseases promptly affect the health of pets, cause abnormal behaviors of pets, make pets produce peculiar smell, also reduce the ornamental value of pets, and even threaten the health of animal owners' families. Moreover, these diseases are also very common. [0003] In the prior art, the products used to treat ear diseases and mixed infection skin diseases are mainly ofloxacin ear drops, which have a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic gram-negative bacilli. Good antibacterial effect in vitro: most bacteria of Enterobacteri...

AI Technical Summary

Problems solved by technology

[0004] Ofloxacin solution takes a long time to sterilize and has low bactericidal intensity, so it is difficult to kill harmful bacteria quickly and completely. Long-term use may also produce drug resistance, thereby reducing the therapeutic effect of the drug

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