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Preparation method and application of camellia flavonoid for reducing blood glucose

A technology of hypoglycemic and Camellia oleifera, applied in hypoglycemic drugs and health care products, in the field of preparation of camellia oleifera flavonoids for hypoglycemic, can solve problems such as lactic acid poisoning, limited application, side effects of digestive tract, etc. Good blood sugar lowering effect

Active Publication Date: 2013-10-09
上海光声制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although such drugs have been used to treat diabetes in the late 1950s, they have a high incidence of adverse reactions, mainly having obvious gastrointestinal side effects and lactic acid poisoning, which limit their application.

Method used

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  • Preparation method and application of camellia flavonoid for reducing blood glucose
  • Preparation method and application of camellia flavonoid for reducing blood glucose
  • Preparation method and application of camellia flavonoid for reducing blood glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of hypoglycemic camellia flavonoid, the structure of said camellia flavonoid is as follows:

[0041]

[0042] The camellia flavone is kaempferol 3-0-[2-O-β-D-xylose-6-O-α-L-rhamnose]-β-D-glucoside.

[0043] The preparation method of the described hypoglycemic camellia flavonoids, the preparation method comprises the following steps:

[0044] A. The dried camellia meal is pulverized to increase the contact area between the camellia meal and the solvent, improve the efficiency, and obtain the pulverized camellia meal; the pulverization process uses mechanical pulverization, and the particle size of the pulverized camellia meal is 4-200 head;

[0045] B. Under static or dynamic conditions, the pulverized Camellia oleifera meal is extracted with a solvent, the extraction temperature is from room temperature to the solvent reflux temperature, and the weight-number ratio of the solvent to the pulverized Camellia oleifera meal is 4-14:1 to obtain Camellia oleifera...

Embodiment 2

[0059] Another embodiment of a preparation method of hypoglycemic camellia oleifera flavonoids, this embodiment is a preferred solution based on embodiment 1, the quality of the raw materials used is the same as that of embodiment 1, and the same as embodiment 1 in this embodiment Please refer to the content disclosed in Embodiment 1 for understanding, and the content disclosed in Embodiment 1 should also be regarded as the content of this embodiment.

[0060] The preparation method of the described hypoglycemic camellia flavonoids, the preparation method comprises the following steps:

[0061] A. Take 1 kg of dried tea-oleifera meal and carry out pulverization treatment, obtain the camellia oleifera meal after pulverization process;

[0062] B. 10kg of petroleum ether is used to degrease the pulverized Camellia oleifera meal to obtain the degreased Camellia oleifera meal;

[0063] C. The oil-tea camellia meal after the degreasing treatment was dried, extracted with 70% et...

Embodiment 3

[0068] Another embodiment of a preparation method of hypoglycemic camellia oleifera flavonoids, this embodiment is a preferred solution based on embodiment 1, the quality of the raw materials used is the same as that of embodiment 1, and the same as embodiment 1 in this embodiment Please refer to the content disclosed in Embodiment 1 for understanding, and the content disclosed in Embodiment 1 should also be regarded as the content of this embodiment.

[0069] The preparation method of the described hypoglycemic camellia flavonoids, the preparation method comprises the following steps:

[0070] A. Get 2kg of dry tea-oleil meal and carry out pulverization process, obtain the camellia meal after pulverization process;

[0071] B. 20kg of petroleum ether is used to degrease the pulverized Camellia oleifera meal to obtain the Camellia oleifera meal after the degreasing treatment;

[0072] C. The oil-tea camellia meal after the degreasing treatment was dried, extracted with 70%...

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Abstract

The invention relates to a preparation method and application of camellia flavonoid for reducing blood glucose. The camellia flavonoid is kaempferol-3-0-[2-O-beta-D- xylose-6-O-alpha-rhamnose]-beta-D-glucoside. Compared with the prior art, the preparation method of the camellia flavonoid for reducing the blood glucose has the following beneficial effects that seed cakes obtained after the camellia seed is squeezed for oil extraction are applied to the preparation and separation of the active ingredient for reducing the blood glucose; and the camellia flavonoid obtained by using the preparation method provided by the invention can be used as a medicine and healthcare food for diabetes mellitus, has good blood glucose reducing effect and hardly damages a human body.

Description

technical field [0001] The invention relates to the field of medicines and health care products, in particular to a preparation method of hypoglycemic camellia flavonoids and its application in blood sugar lowering medicines and health care products. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a group of chronic metabolic disorder syndromes characterized by persistent hyperglycemia. Caused by relative or absolute deficiency of insulin and decreased sensitivity of target tissues to insulin (insulin resistance), resulting from a combination of genetic and environmental factors. According to the relevant data of WHO, the morbidity, morbidity, mortality and overall health hazards of diabetes have been listed as the third of non-communicable diseases. Diabetes has become the third threat to human health after cardiovascular diseases and tumors. big disease. [0003] According to statistics, there are 90 million type 2 diabetes patients in China, and ...

Claims

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Application Information

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IPC IPC(8): C07H17/07A61K31/7048A23L1/29A61P3/10A23L33/00
Inventor 吉腾飞叶菲张绍良
Owner 上海光声制药有限公司
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