A flavoring and moisturizing agent 1-l-tryptophan-1-deoxy-d-fructose for tobacco and its preparation method

A technology of moisturizing agent and tryptophan for cigarettes, applied in the preparation of sugar derivatives, chemical instruments and methods, tobacco and other directions, can solve the problems of unsatisfactory improvement effect of smoking comfort, and achieve the effect of reasonable synthesis route

Active Publication Date: 2016-04-27
CHINA TOBACCO HENAN IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]Currently, glycerin, propylene glycol, sorbitol and other polyhydroxy substances are mainly used as humectants in the cigarette industry in my country. The main function of using such humectants is to maintain the The moisture content of shredded tobacco during the process can improve the processing resistance of shredded tobacco, but the above-mentioned humectants are not ideal for maintaining the moisture content of finished cigarettes and improving smoking comfort

Method used

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  • A flavoring and moisturizing agent 1-l-tryptophan-1-deoxy-d-fructose for tobacco and its preparation method
  • A flavoring and moisturizing agent 1-l-tryptophan-1-deoxy-d-fructose for tobacco and its preparation method
  • A flavoring and moisturizing agent 1-l-tryptophan-1-deoxy-d-fructose for tobacco and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of 1-L-tryptophan-1-deoxy-D-fructose, it comprises the steps:

[0026] Weigh 0.06mol of D-mannose into a 500mL three-neck flask, add 168mL of anhydrous methanol, magnetically stir and reflux for 20 minutes, then add 0.048mol of tryptophan and 0.0012mol of citric acid in sequence, and then reflux for another 4 hours to end the reaction. After the reaction solution was cooled to room temperature, the unreacted D-mannose and amino acids were filtered off, and then concentrated under reduced pressure, separated by strong acid ion exchange resin column chromatography and recrystallized to obtain 8.765 g of the white target product with a yield of 39.89%.

[0027] When separating, first add the synthetic sample aqueous solution to the resin column, and then use distilled water to wash off impurities such as unreacted D-mannose and uncharged substances, and then use 1mol / L HCl aqueous solution to wash, and use a specific method to wash at any time. Monit...

Embodiment 2

[0029] The preparation method of 1-L-tryptophan-1-deoxy-D-fructose, it comprises the steps:

[0030] Weigh 0.06mol of D-mannose into a 500mL three-necked flask, add 200mL of anhydrous methanol, magnetically stir and reflux for 30min, then add 0.06mol of tryptophan and 0.0024mol of citric acid in sequence, and then reflux for 5.5h to end the reaction. After the reaction liquid was cooled to room temperature, the unreacted D-mannose and amino acid were filtered off, then concentrated under reduced pressure, separated by strong acid ion exchange resin column chromatography and recrystallized to obtain 14.834 g of the white target product with a yield of 67.52%.

[0031] When separating, first add the synthetic sample aqueous solution to the resin column, and then use distilled water to wash off impurities such as unreacted D-mannose and uncharged substances, and then use 1mol / L HCl aqueous solution to wash, and use a specific method to wash at any time. Monitor the eluent, when t...

Embodiment 3

[0033] The preparation method of 1-L-tryptophan-1-deoxy-D-fructose, it comprises the steps:

[0034] Weigh 0.06mol of D-mannose into a 500mL three-neck flask, add 240mL of anhydrous methanol, magnetically stir and reflux for 40min, then add 0.072mol of tryptophan and 0.003mol of citric acid in sequence, and then reflux for another 7h to end the reaction. After the reaction solution was cooled to room temperature, the unreacted D-mannose and amino acid were filtered off, then concentrated under reduced pressure, separated by strong acid ion exchange resin column chromatography and recrystallized to obtain 10.032 g of the white target product with a yield of 45.66%.

[0035] When separating, first add the synthetic sample aqueous solution to the resin column, and then use distilled water to wash off impurities such as unreacted D-mannose and uncharged substances, and then use 1mol / L HCl aqueous solution to wash, and use a specific method to wash at any time. Monitor the eluent, ...

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Abstract

The invention discloses a flavor-enhancing moisturizer 1-L-tryptophan-1-deoxy-D-fructose for cigarettes. As a raw material, a flavor-enhancing humectant 1-L-tryptophan-1-deoxy-D-fructose for cigarettes was successfully synthesized through a simple reaction process. Through physical moisturizing performance tests and intrinsic sensory quality evaluations, it was found that The humectant has a good physical moisturizing effect on cigarettes, and can reduce the irritation and miscellaneous gas of cigarettes, and improve the roundness and comfort of cigarette smoke.

Description

technical field [0001] The invention belongs to the technical field of humectants, and in particular relates to 1-L-tryptophan-1-deoxy-D-fructose flavoring humectant for tobacco and a preparation method thereof. Background technique [0002] At present, glycerin, propylene glycol, sorbitol and other polyhydroxy substances are mainly used as humectants in my country’s cigarette industry. The main function of using such humectants is to maintain the moisture content of shredded tobacco during processing and improve the processing resistance of shredded tobacco. The above-mentioned humectant has unsatisfactory effects on maintaining the moisture content of finished cigarettes and improving smoking comfort. Contents of the invention [0003] The object of the present invention is to provide a kind of aroma-enhancing humectant 1-L-tryptophan-1-deoxy-D-fructose for tobacco, and another object of the present invention is to provide the preparation method of this aroma-enhancing hu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/26C07H1/00A24B15/36
Inventor 陈芝飞芦昶彤戴建国孙志涛魏明杰李红涛屈展马骥
Owner CHINA TOBACCO HENAN IND
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