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Sea urchin-shaped hollow gold and silver alloy nano particle and preparation method and application thereof

A gold-silver alloy and nanoparticle technology, which is applied in the interdisciplinary field of nanoscience and biological science, can solve the problems of poor electric field enhancement effect, complicated preparation method, and low detection sensitivity, and achieve uniform appearance, simple process method, and repeatability Good results

Inactive Publication Date: 2013-10-23
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, the prepared gold nanoparticles such as: gold nanospheres, gold flowers, gold stars, etc. have poor electric field enhancement effects, low detection sensitivity, poor repeatability, and complicated preparation methods

Method used

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  • Sea urchin-shaped hollow gold and silver alloy nano particle and preparation method and application thereof
  • Sea urchin-shaped hollow gold and silver alloy nano particle and preparation method and application thereof
  • Sea urchin-shaped hollow gold and silver alloy nano particle and preparation method and application thereof

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Effect test

Embodiment 1

[0040] 1) Dissolve 9 mg of silver nitrate in 50 mL of ultrapure water, heat to boiling, then quickly add 1.2 mL of 1% trisodium citrate aqueous solution, keep boiling for 20 minutes, and then cool to room temperature to obtain particle size 20nm silver colloid;

[0041] 2) Dilute 2.4mL to a concentration of 10×10 -3 Add mol / L chloroauric acid solution and 4.3mL ultrapure water into a 25mL glass bottle, then stir at 300 rpm at 15°C, add 0.9mL silver colloid and 2.4mL The concentration is 10×10 -3 mol / L levodopa aqueous solution, after adding the levodopa aqueous solution, continue to stir with a stirring speed of 300 rpm for 1 minute, and then stir with a stirring speed of 100 rpm for 4 minutes to obtain a reaction solution; the reaction solution is centrifuged , the solid product obtained by centrifugation is washed once with formic acid of 500mmol / L and ammonia water with a mass concentration of 25-28%, and then washed twice with ultrapure water to obtain sea urchin-shaped ...

Embodiment 2

[0044] 1) Dissolve 9 mg of silver nitrate in 50 mL of deionized water, heat to boiling, then quickly add 1.2 mL of trisodium citrate aqueous solution with a mass concentration of 1%, keep boiling for 20 minutes, and then cool to room temperature to obtain a particle size of 20nm silver colloid;

[0045] 2) Dilute 2.4mL to a concentration of 10×10 -3 mol / L chloroauric acid solution and 5.1mL of deionized water were added to a 25mL glass bottle, and then stirred at a stirring speed of 200 rpm at 15°C. During the stirring process, 0.9mL of silver colloid and 2.4 Concentration in mL is 10×10 -3 mol / L levodopa aqueous solution, then stirred and reacted for 4 minutes at a stirring speed less than 200 revolutions per minute to obtain a reaction solution; the reaction solution was centrifuged, and the solid product obtained by centrifugation was successively washed with 500 mmol / L formic acid, mass concentration Wash once with 25-28% ammonia water, and then wash twice with ultrapure...

Embodiment 3

[0047] 1) Dissolve 4 mg of silver nitrate in 50 mL of deionized water, heat to boiling, then quickly add 0.6 mL of trisodium citrate aqueous solution with a mass concentration of 1%, keep boiling for 3 minutes, and then cool to room temperature to obtain silver colloid;

[0048] 2) Dilute 2.4mL to a concentration of 10×10 -3 Add mol / L chloroauric acid solution and 4mL deionized water into a 25mL glass bottle, then stir at a stirring speed of 200 rpm at 15°C, add 0.1mL silver colloid and 2.4mL The concentration is 10×10 -3 mol / L levodopa aqueous solution, then stirred and reacted for 4 minutes at a stirring speed less than 200 revolutions per minute to obtain a reaction solution; the reaction solution was centrifuged, and the solid product obtained by centrifugation was successively washed with 500 mmol / L formic acid, mass concentration Wash once with 25-28% ammonia water, and then wash twice with ultrapure water to obtain sea urchin-shaped hollow gold-silver alloy nanoparticl...

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Abstract

The invention discloses a sea urchin-shaped hollow gold and silver alloy nano particle and a preparation method and application thereof. The method comprises the following steps: dissolving silver nitrate into water; heating the mixture of the silver nitrate and the water till boiling; adding trisodium citrate aqueous solution in the mixture and keeping boiling for 3-30 minutes to obtain a silver colloid; mixing chloroauric acid aqueous solution and the water; adding the silver colloid under the condition of agitation at the temperature of 15 DEG C; adding hemoporphyrin metalporphyrin aqueous solution and obtaining a reaction solution after 5 min reaction; performing centrifugalization of the reaction solution, washing deposit obtained via centrifugalization, and obtaining the sea urchin-shaped hollow gold and silver alloy nano particle. The diameter of the nano particle is 80 nm-300 nm, the hollow size is 20 nm-50 nm, the length of a stab is 10 nm-30 nm, the diameter of the stab is 10 nm. The preparation method is simple, low in cost, gentle in condition, short in time, easy in process control, and large in production capacity. The obtained nano particle can be well applied to organic molecule detection, earlier detection of tumour and photothermal treatment.

Description

technical field [0001] The invention belongs to the interdisciplinary field of nanoscience and biological science, and in particular relates to a sea urchin-shaped hollow gold-silver alloy nanoparticle and a preparation method and application thereof. Background technique [0002] Nanotechnology is a major breakthrough in people's understanding of materials. The unique mechanical, thermal, and optical properties of nanomaterials make them have great application prospects in various fields. When the incident electromagnetic wave irradiates the surface of nanoscale metal nanoparticles, especially the surface of noble metal nanoparticles, the incident electromagnetic wave interacts with the free charges on the metal surface to generate surface plasmons, which can greatly increase the intensity of the light field. Due to its stability and good biocompatibility, gold nanoparticles are widely used in chemical trace detection, organic pollutant detection, early detection and treatm...

Claims

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Application Information

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IPC IPC(8): B22F9/24C22C5/02G01N21/65G01N33/68A61K41/00A61P35/00
Inventor 方吉祥刘真张蕾杨忠波
Owner XI AN JIAOTONG UNIV
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