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Tianshan dracocephalum extract and application thereof

A technology of extract and extract, applied in Tianshan Qinglan extract and its application field, can solve the problems such as no elastase inhibition, and achieve good inhibitory effect

Active Publication Date: 2013-11-13
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report of its elastase inhibitory effect

Method used

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  • Tianshan dracocephalum extract and application thereof
  • Tianshan dracocephalum extract and application thereof
  • Tianshan dracocephalum extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The concentration selection of embodiment 1 extraction solvent (ethanol)

[0025] Take 20g of dried and pulverized powder of Tianshan Qinglan herb, cold-soak in 200ml of ethanol with a volume concentration of 50% at room temperature, and ultrasonically extract twice, each time for 30min (500W). Take the filtrates and combine them, and recover the solvent under reduced pressure until dry. Take an appropriate amount of the extract and prepare a 0.05 mg / ml solution for later use.

[0026] Take 20g of dried and pulverized powder of Tianshan Qinglan whole grass, cold-soak in 200ml of ethanol with a volume concentration of 70% at room temperature, and ultrasonically extract twice, each time for 30min (500W), combine the filtrates, recover the solvent under reduced pressure to dryness, An appropriate amount of extract is prepared into a 0.05mg / ml solution for later use.

[0027] Take 20g of dried and pulverized powder of Tianshan Qinglan whole grass, cold-soak in 200ml of eth...

Embodiment 2

[0034] The selection of embodiment 2 solid-liquid ratio

[0035] Take 20g of the dried and pulverized powder of Tianshan Qinglan whole grass, cold-soak in 160ml of ethanol with a volume concentration of 95% at room temperature, and ultrasonically extract twice, each time for 30min (500W), take the filtrates and combine them, recover the solvent under reduced pressure until dry, An appropriate amount of extract is prepared into a 0.05mg / ml solution for later use.

[0036] Take 20g of the dried and pulverized powder of Tianshan Qinglan whole grass, cold-soak in 200ml of ethanol with a volume concentration of 95% at room temperature, and ultrasonically extract twice, each time for 30min (500W). An appropriate amount of extract is prepared into a 0.05mg / ml solution for later use.

[0037] Take 20g of the dried and pulverized powder of Tianshan Qinglan whole grass, cold-soak in 240ml of ethanol with a volume concentration of 95% at room temperature, and ultrasonically extract twic...

Embodiment 3

[0043] The preparation of embodiment 3 Tianshan Qinglan extract

[0044]Tianshan Qinglan powder 50g, soaked in 500ml of 95% ethanol at room temperature, ultrasonically extracted twice, each time for 30min (500W power), the filtrates were combined, and the solvent was recovered under reduced pressure until there was no alcohol smell (about 100mL) to obtain the crude extract ; Extract 2 times with petroleum ether, 100mL each time, collect and combine the extracts, and evaporate to dryness under reduced pressure to obtain 1.15g of petroleum ether extract of Tianshan Qinglan; 2 times with ethyl acetate as solvent extraction, each time 100mL, collect and combine the extracts, evaporate to dryness under reduced pressure, and obtain 1.84g of the extract of ethyl acetate of Tianshan Qinglan; finally use n-butanol as the solvent to extract 2 times, 100mL each time, collect and combine the extracts, evaporate under reduced pressure Dry to obtain 1.01 g of n-butanol extract of Tianshan Q...

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Abstract

The invention relates to the field of a plant extract and an application thereof, and particularly relates to a Tianshan dracocephalum extract and an application thereof. The preparation method of the Tianshan dracocephalum extract comprises the following steps of drying and crushing the whole herb of Tianshan dracocephalum, and mixing with an ethanol aqueous solution; performing ultrasonic extraction at room temperature to obtain an extracting solution; performing reduced-pressure recovery of a solvent from the extracting solution to obtain a crude extract of Tianshan dracocephalum; and extracting the crude extract of Tianshan dracocephalum, and performing reduced-pressure recovery of the solvent to obtain the Tianshan dracocephalum extract. Experiments show that the Tianshan dracocephalum extract provided by the invention has a good inhibition effect on elastase, wherein the inhibition rate on elastase can reach 51%.

Description

technical field [0001] The present invention relates to the field of plant extract and its application, in particular to a Tianshan Qinglan extract and its application. Background technique [0002] Elastase is a destructive enzyme present in the human body. It is released from white blood cells stimulated by inflammation. It can hydrolyze certain connective tissue components such as elastin, proteoglycan and certain types of collagen. Therefore, it is widely involved in the human body. Tissue damage response in vivo. The overexpression and overactivity of elastase are involved in the pathological process of various diseases. Studies have shown that elastase is closely related to inflammatory response, autoimmunity, tumor formation and metastasis. Elastase inhibitors can inhibit the expression or activity of elastase, and the development of elastase inhibitors as drugs for treating inflammation-related diseases and anticancer drugs has become a new hot spot in drug develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A23L1/29A61K8/97A61P29/00A61P35/00A61P37/02A61Q19/08A61Q19/00A23L33/00
Inventor 金家宏夏增华李慧
Owner JALA GROUP CORPORATION
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