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Externally used compound traditional Chinese medicine for treating cancer induced bone pain

A related, compound drug technology, applied in anti-tumor drugs, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems affecting quality of life, lethargy and constipation, serious adverse reactions, etc. Good effect, reduced overexpression, good application prospects

Inactive Publication Date: 2013-11-20
司马蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, opioids are prone to tolerance, and high-dose opioids are accompanied by severe adverse reactions such as respiratory depression, lethargy, and constipation, which seriously affect the quality of life

Method used

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  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain
  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain
  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Effect of traditional Chinese medicine on 50% withdrawal threshold of mechanical stimulation

[0027] 1Materials and methods

[0028] (1) Laboratory animals, drugs and equipment

[0029] Wistar rats: Provided by Weitong Lihua Animal Experiment Center, 40 healthy males weighing 200-260g, divided into four groups: sham operation group, bone cancer pain group, morphine group and morphine + Chinese medicine group, each with 10 rats. Compound traditional Chinese medicine: 80g of Sichuan aconite, 80g of psoralen, 60g of psoralen, 30g of frankincense, 30g of myrrh, 30g of earthworm, 15g of dried ginger, 15g of borneol. Put the sesame oil in a pot, put in the above proportions of Chuanwu, Caowu, Psoralen, Frankincense, Myrrh, Dilong, soak for more than 24 hours, then start heating, switch to a slow fire when the oil is near boiling, keep the oil in a slight boiling To facilitate the extraction of the active ingredients of the medicine, about 2 hours later, remove the medic...

Embodiment 2

[0045] Example 2 Effect of Chinese Medicine on Thermal Stimulus Hyperesthesia

[0046] 1 Materials and methods (same as Example 1)

[0047] 2 results

[0048] On the 6th day after inoculation, bone cancer pain caused thermal hyperalgesia. The heat shrinkage latency of the three groups of rats inoculated with cancer cells was shorter than that of the control group. After treatment with morphine, the incubation period on the first day of the morphine group increased rapidly to 26.3, but soon the morphine tolerance and analgesic effect was weakened, and it dropped to 20.7 at M5. The incubation period of the morphine + traditional Chinese medicine group increased to 26.9 on the first day of treatment, and the incubation period from M5 to M9 has been longer than that of the morphine group (P<0.01), Table 2.

[0049] Table 2 Changes in latency of heat shrinking foot reflex

[0050]

[0051] * : Compared with the morphine + traditional Chinese medicine group, the morphine group has P<0.01. ...

Embodiment 3

[0052] Example 3 Chinese medicine content of peripheral blood β-endorphin

[0053] 1 Materials and methods (same as Example 1)

[0054] 2 results

[0055] At the end of the experiment, the levels of plasma β-endorphin in the morphine group and the morphine+Chinese medicine group were significantly higher than those in the bone cancer pain group (P<0.001), and the morphine+Chinese medicine group was higher than the morphine group (P<0.05).

[0056] Table 3 Comparison of plasma β-endorphin content at the end of the experiment (pg / ml)

[0057]

T0

T6

M3

M9

Control group

104.3±25.1

113.6±20.5

124.1±25.6

119.8±28.4

Bone Cancer Pain Group

111.3±26.9

125.6±29.9

135.9±38.2 #

130.4±33.2 #

Morphine group

102.8±17.6

116.5±18.9

185.4±30.2 #*

190.2±27.6 #*

Morphine + Chinese medicine group

114.6±23.7

137.4±25.3

210.2±32.4 #*

215.8±29.9 #*

[0058] #: After analgesia treatment, the plasma β-endorphin levels in the morphine group and the morphine+Chinese medicine group we...

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Abstract

Cancer induced bone pain has high incidence and severe pain, is a major cause for hard control of terminal cancer pain. Opium and other analgesic drugs are prone to generate tolerance, and are associated with serious adverse responses, such as respiratory depression, drowsiness, constipation and the like, so that the quality of life is seriously affected. By means of rat tibial cancer pain model pharmacological experiments, the invention proves that: the externally used compound traditional Chinese medicine (made of Radix Aconiti, Radix Aconiti Kusnezoffii, Fructus Psoraleae, frankincense, myrrh, earthworm, dried ginger, and borneol) provided in the invention can significantly alleviate cancer induced bone pain, the economic cost is low, administration is convenient, adverse responses are fewer. Thus, the externally used compound traditional Chinese medicine is an effective assistant analgesic drug, and has good application prospects.

Description

One technical field [0001] The invention relates to a compound traditional Chinese medicine for external use, in particular to a compound traditional Chinese medicine capable of effectively treating tumor-related bone pain. 2. Background technology [0002] At present, there are 12.7 million new cancer patients worldwide each year, and 7.6 million cancer deaths each year. 56% of advanced patients have experienced moderate to severe cancer pain for at least one month. The incidence of bone metastasis of common malignant tumors such as lung cancer, breast cancer and prostate cancer is as high as 30-40%, 65-75%, and 65-75%. Because of the abundant sensory nerves distributed on the periosteum, the tumor invades the periosteum and causes bone destruction to produce severe nociceptive pain. The diseased sensory nerves may further undergo sensitization and remodeling, resulting in neuropathic pain. Therefore, cancer induced bone pain (CIBP) mixing these two pain characteristics is the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61P35/00A61P19/08A61P29/00A61K31/045A61K35/56A61K35/62
Inventor 司马蕾樊碧发
Owner 司马蕾
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