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Externally used compound traditional Chinese medicine for treating cancer induced bone pain

A related and compound drug technology, applied in the direction of antineoplastic drugs, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems affecting the quality of life, drowsiness and constipation, serious adverse reactions, etc. Good effect, reduced overexpression, good application prospects

Inactive Publication Date: 2014-12-17
司马蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, opioids are prone to tolerance, and high-dose opioids are accompanied by severe adverse reactions such as respiratory depression, lethargy, and constipation, which seriously affect the quality of life

Method used

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  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain
  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain
  • Externally used compound traditional Chinese medicine for treating cancer induced bone pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Experimental animals, drugs and instruments

[0027] Wistar rats: Provided by Weitong Lihua Animal Experiment Center, 40 healthy males, weighing 200-260g, were divided into four groups: sham operation group, bone cancer pain group, morphine group and morphine + traditional Chinese medicine group, with 10 rats in each group. Compound Chinese medicine: Chuanwu 80g, Caowu 80g, psoralen 60g, frankincense 30g, myrrh 30g, earthworm 30g, dried ginger 15g, borneol 15g. Put the sesame oil in the pot, add Aconitum aconitum, Aconitum aconitum, psoralen, frankincense, myrrh, and earthworm according to the above ratio, soak for more than 24 hours, then start heating, when the oil is almost boiling, use a slow fire to keep the oil at a slight boil After about 2 hours, remove the dregs and take out the medicinal oil, wrap the yellow wax in the oil pan with gauze, remove the gauze after the yellow wax dissolves, place the medicinal oil at 40-50°C, and put the dried The fine powder...

Embodiment 2

[0045] 2 results

[0046] On the 6th day after inoculation, bone cancer pain caused thermal hyperalgesia, and the paw withdrawal latency of the three groups inoculated with cancer cells was shorter than that of the control group. After treatment with morphine, the latency of the morphine group increased rapidly to 26.3 on the first day, but the analgesic effect of morphine tolerance soon weakened, and decreased to 20.7 at M5. The latency of the morphine + traditional Chinese medicine group increased to 26.9 on the first day of treatment, and the latency from M5 to M9 was longer than that of the morphine group (P<0.01), Table 2.

[0047] Table 2 Changes in the latent period of heat withdrawal reflex

[0048]

[0049] * : P<0.01 between the morphine group and the morphine+Chinese medicine group. T0-M9: before cancer cell inoculation, on days 1, 3, and 6 after inoculation, and on days 1, 3, 5, 7, and 9 of morphine injection.

[0050] Embodiment 3 traditional Chinese medi...

Embodiment 3

[0052] 2 results

[0053] At the end of the experiment, the plasma β-endorphin content of the morphine group and the morphine+Chinese medicine group was significantly higher than that of the bone cancer pain group (P<0.001), and the content of the morphine+Chinese medicine group was higher than that of the morphine group (P<0.05).

[0054] Comparison of plasma β-endorphin content at the end of the experiment in table 3 (pg / ml)

[0055]

T0

T6

M3

M9

control group

104.3±25.1

113.6±20.5

124.1±25.6

119.8±28.4

bone cancer pain group

111.3±26.9

125.6±29.9

135.9±38.2 #

130.4±33.2 #

Morphine group

102.8±17.6

116.5±18.9

185.4±30.2 #*

190.2±27.6 #*

Morphine + traditional Chinese medicine group

114.6±23.7

137.4±25.3

210.2±32.4 #*

215.8±29.9 #*

[0056] #: After analgesic treatment, the plasma β-endorphin content of the morphine group and the morphine + traditional...

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Abstract

Cancer induced bone pain has high incidence and severe pain, is a major cause for hard control of terminal cancer pain. Opium and other analgesic drugs are prone to generate tolerance, and are associated with serious adverse responses, such as respiratory depression, drowsiness, constipation and the like, so that the quality of life is seriously affected. By means of rat tibial cancer pain model pharmacological experiments, the invention proves that: the externally used compound traditional Chinese medicine (made of Radix Aconiti, Radix Aconiti Kusnezoffii, Fructus Psoraleae, frankincense, myrrh, earthworm, dried ginger, and borneol) provided in the invention can significantly alleviate cancer induced bone pain, the economic cost is low, administration is convenient, adverse responses are fewer. Thus, the externally used compound traditional Chinese medicine is an effective assistant analgesic drug, and has good application prospects.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine for external use, in particular to a compound traditional Chinese medicine capable of effectively treating tumor-related bone pain. Background technique [0002] At present, there are 12.7 million new cancer patients every year in the world, and 7.6 million cancer deaths every year. 56% of advanced patients experience moderate to severe cancer pain for at least one month. Common malignant tumors such as lung cancer, breast cancer, and prostate cancer have bone metastasis rates as high as 30-40%, 65-75%, and 65-75%. Due to the rich distribution of sensory nerves on the periosteum, the tumor invades the periosteum and causes bone destruction to produce severe nociceptive pain, and the lesioned sensory nerves may further sensitize and remodel, resulting in neuropathic pain, so cancer-related bone pain (Cancerinducedbonepain, CIBP) The combination of these two pain characteristics is the mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P35/00A61P19/08A61K36/9068A61K31/045A61P29/00A61K35/56A61K9/06A61K35/62
Inventor 司马蕾樊碧发
Owner 司马蕾
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