Drug composition for treating infantile diarrhea and preparation method thereof

A technology for children's diarrhea and a composition, applied in the field of traditional Chinese medicine, can solve the problems of increasing patient suffering, patient side effects, weak symptomaticity and the like, and achieves the effects of low cost, high bioavailability and small dosage

Inactive Publication Date: 2013-11-27
王怀珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine prescriptions in the prior art lack dialectics, the treatment cycle is long, the symptoms are not strong, the curative effect is not obvious, and...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A pharmaceutical composition for treating infantile diarrhea, which is prepared from the following raw materials in weight ratio:

[0021] 30 parts of white lentils, 27 parts of pulsatilla, 25 parts of red peony, 25 parts of curcuma, 25 parts of dandelion,

[0022] 22 parts of radish seed, 22 parts of Atractylodes macrocephala, 20 parts of pomegranate peel, 20 parts of fungus, 18 parts of almond,

[0023] Poria cocos 18 parts, Ling Xiaohua 18 parts, licorice 15 parts, Fangfeng 15 parts, Cyperus cyperi 15 parts,

[0024] 15 parts of perilla leaves, 10 parts of dried ginger, 10 parts of purslane, 10 parts of Citrus aurantium, 10 parts of Albizia juniper,

[0025] 7 parts of Burnet, 7 parts of Chuanxiong, 5 parts of Cortex Phellodendri, 3 parts of Lycium barbarum, and 3 parts of hawthorn.

[0026] Its preparation and taking method of the pharmaceutical composition of the present invention are: take the crude drug (proportioning unit: gram) of above-mentioned parts by wei...

Embodiment 2

[0032] 1. Toxicity test

[0033] In this experiment, healthy SD rats were used, and the dose gradient of the drug prepared in Example 1 was administered orally at 0.05 mg / kg and 1.0 mg / kg. The drug was administered continuously for 30 days, and the rats were observed during the administration period and 1 week after drug withdrawal. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.

[0034] 2. Effects on castor oil-induced diarrhea model in mice

[0035] Get 60 ICR mice, half male and half male, randomly divided into model control group, Smecta group, the present invention (medicine of embodiment 1) group, the model group was given equal volume of normal saline, once a day, for three consecutive days. 40 minutes after the last administration, each animal was given 0.2ml castor oil by intragastric administration. The mice w...

Embodiment 3

[0039] A total of 103 children with acute and chronic diarrhea were tested, including 50 females and 53 males, aged between 8 months and 2 years old. The above patients were randomly divided into two groups: 52 cases in the treatment group and 51 cases in the control group;

[0040] Diagnostic criteria

[0041]According to the diagnostic criteria for infantile diarrhea in the "Practical Pediatric Diagnosis and Treatment Standards", with the pale tongue and white coating as the main basis for the type of spleen deficiency, all patients were diagnosed as infantile diarrhea.

[0042] treatment method

[0043] The treatment group took the medicine prepared in Example 1 orally, 1 g each time for <1 year old, 2 g each time for 1-2 years old, and 3 g each time for 2-3 years old, three times a day.

[0044] The control group took Smecta orally, 1g each time for <1 year old, 2g each time for 1-2 years old, 3g each time for 2-3 years old, all three times a day.

[0045] A course of t...

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PUM

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Abstract

The invention relates to a drug composition for treating infantile diarrhea and a preparation method thereof. The drug composition is prepared from the following raw materials in parts by weight: 30 parts of white hyacinth bean, 27 parts of Chinese pulsatilla root, 25 parts of red peony root, 25 parts of zedoray rhizome, 25 parts of dandelions, 22 parts of radish seed, 22 parts of largehead atractylodes rhizome, 20 parts of pomegranate rinds, 20 parts of agarics, 18 parts of almonds, 18 parts of Indian bread, 18 parts of Chinese trumpet creeper, 15 parts of liquorice, 15 parts of divaricate saposhnikovia root, 15 parts of nutgrass galingale rhizome, 15 parts of perilla leaf, 10 parts of dried ginger, 10 parts of purslane herb, 10 parts of orange fruit, 10 parts of silktree albizia bark, 7 parts of garden burnet root, 7 parts of Sichuan lovage rhizome, 5 parts of amur corktree bark, 3 parts of barbary wolfberry fruit and 3 parts of hawthorns. The drugs are used jointly and bring out the best in each other, so that the drug composition takes an effect on infantile diarrhea quickly and has extensive application prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating infantile diarrhea by using Chinese herbal medicines as raw materials and a preparation method thereof. Background technique [0002] Diarrheal disease in children is a group of common intestinal diseases caused by various pathogens and factors, with diarrhea as the main symptom. It is one of the main diseases that threaten children's health. Modern medicine believes that 80% of children's infections are caused by viruses, and rotavirus is the main pathogen. Other causes include bacterial infection, parasitic infection and fungal infection, mainly due to the damage to the intestinal mucosa caused by viruses, bacteria and their toxins, which hinder the absorption and secretion of water and electrolytes, and a large amount of water stays in the intestinal cavity. Sincerely. At present clinical western med...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/12
Inventor 王怀珍
Owner 王怀珍
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