Method for preparing poecilobdella manillensis medium-high activity anticoagulant crude product
A high-activity technology of Hirudo phenanthrene, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, medical raw materials derived from leeches/worms, etc., can solve the problem of low anticoagulant activity content of dry product powders, and achieve The content of natural anticoagulant substances is large, the effect is good, and the effect of reducing blood viscosity
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[0017] Example 1
[0018] Take 20kg of healthy Philippine cow leeches over 1 year old, and cut the head of Philippine cow leeches mechanically or manually (the front 1 / 3 of the body of the Philippine cow leeches and contain the salivary glands of the Philippine cow leeches) to get 6kg of raw materials, according to the weight ratio of 1:4 Mix it with a sodium chloride solution with a mass concentration of 0.8%, and place the mixture in a cold room at 4 to 6°C so that the temperature of the mixture reaches 4 to 6°C;
[0019] Repeat the grinding steps with a colloid mill with cooling device The temperature of the mixture is controlled at 4~6℃ (the highest temperature of the whole process of the same batch does not exceed 10℃), the mixture is repeatedly milled in the colloid mill and the residence time does not exceed 30s each time, and the rotation speed is above 2800n / min, so that The raw material of Philippine bull leech in the mixture becomes a slurry of 2~50μm, and then the re...
Example Embodiment
[0022] Example 2
[0023] Take 20kg of healthy Philippine cow leeches over 1 year old, and cut the head of Philippine cow leeches mechanically or manually (the front 1 / 3 of the body of the Philippine cow leeches and contain the salivary glands of the Philippine cow leeches) to get 6kg of raw materials, according to the weight ratio of 1:4 Mix it with a sodium chloride solution with a mass concentration of 1.0%, and place the mixture in a cold room at 4 to 6°C so that the temperature of the mixture reaches 4 to 6°C;
[0024] Repeated grinding steps with a colloid mill with cooling device The temperature of the mixture is controlled at 4~6℃ (the highest temperature of the whole process of the same batch is not more than 10℃), the mixture is repeatedly milled in the colloid mill and the residence time is not more than 30s each time, and the rotation speed is above 2800n / min. The raw material of Philippine bull leech in the mixture becomes a slurry of 2~50μm, and then the refined sl...
Example Embodiment
[0027] Example 3
[0028] Take 20kg of healthy phyllo leeches over 1 year old, and cut the head of Philippine cow leeches (the front 1 / 3 of the body of the Philippine cow leeches and contain the salivary glands of the Philippine cow leeches) mechanically or manually to obtain 6 kg of raw materials, according to the weight ratio of 1:6 Mix it with a sodium chloride solution with a mass concentration of 0.8%, and place the mixture in a cold room at 4 to 6°C so that the temperature of the mixture reaches 4 to 6°C;
[0029] Repeat the grinding steps with a colloid mill with cooling device The temperature of the mixture is controlled at 4~6℃ (the highest temperature of the whole process of the same batch is not more than 10℃), the mixture is repeatedly milled in the colloid mill and the residence time is not more than 30s each time, and the rotation speed is above 2800n / min. The raw material of Philippine bull leech in the mixture becomes a slurry of 2~50μm, and then the refined slur...
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