Preparation method of fructus forsythiae extract lignan and application of extract in blood sugar reducing drugs

Abstract

The invention relates to a preparation method of a fructus forsythiae extract lignan and an application of the extract in blood sugar reducing drugs. The problem that a substance for preparing the blood sugar reducing drugs can be extracted from fructus forsythiae can be effectively solved. The extract is obtained through the following steps of crushing fructus forsythiae into medical powder, soaking the medical powder in ethanol for 0.5 h, carrying out reflux extraction twice, abandoning filter residue to obtain an extract liquid, performing decompression concentration on the extract liquid until no alcohol smell is left, adjusting the concentration of the medical liquid to be equivalent to contain 0.5 g / ml of a crude drug, thereby obtaining a sample liquid; applying the sample liquid to a type AB-8 macroporous adsorption resin column; eluting by using water in an amount which is 8 times of the volume of the column to obtain and abandon an eluate I; next, eluting by using ethanol in an amount which is 8 times of the volume of the column so as to obtain and abandon an eluate II; and finally, eluting by using ethanol in an amount which is 10 times of the volume of the column so as to obtain an eluate III, recovering the ethanol, and then carrying out decompression concentration and drying to obtain the fructus forsythiae lignan. According to the invention, the raw materials are rich, the preparation method is simple, the prepared fructus forsythiae lignan has the effect of reducing blood sugar and can be effectively used for preparing the blood sugar reducing drugs; therefore, a new application of treating diabetes is developed.

Description

technical field [0001] The invention relates to medicine, in particular to a preparation method of forsythia extract lignan and its application in hypoglycemic drugs. Background technique [0002] Diabetes is a chronic metabolic disease characterized by chronic hyperglycemia caused by the interaction of environmental factors and genetic factors. Its symptoms are usually referred to as "hyperglycemia" in China. Long-term high blood sugar can lead to microvascular endothelial lesions, and the accompanying abnormal protein and fat metabolism can cause abnormalities in the structure and function of the heart, brain, kidney, nerves, blood vessels, etc., and even lead to organ failure and life-threatening. The fruity flavor gives it the nickname "the silent killer", especially adult-onset diabetes, which can reduce life expectancy by an average of ten years for diabetic patients. And the complications that occur can spread all over the body. The complications of diabetes include:...

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Problems solved by technology

[0006] Forsythia is the dried fruit of the plant Forsythia genus Forsythia in Oleaceae. It is a traditional Chinese medicine and has been recorded in the "Pharmacopoeia of the People's Republic of China". , dissipating stagnation, reducing swelling, and evacuating wind-heat. It is clinically used to treat the initial onset of febrile disease, wind-heat cold, fever, upset, sore throat, macule, erysipelas, etc. It has antibacterial, antiviral, anti-inflammatory, and anti-endogenous properties. Toxin, hepatoprotective, diuretic, antipyretic, anti-allergic, hypoglycemic, etc., but there are few clinical reports on the treatment of diabetes

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