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Arctigenin sublingual preparation

A technology of sublingual administration of arctigenin, which is applied in the field of medicine to achieve the effects of fast blood flow, improved quality of life, and convenient administration

Inactive Publication Date: 2013-12-18
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the preparation that is specially used for sublingual administration is not universal at present, and this is mainly due to the difference in the physicochemical property of different medicines, and not all medicines can be prepared into sublingual administration preparation; There are still obvious deficiencies in drug dosage, drug absorption, and dosage form, etc. The development of drugs into suitable sublingual drug formulations requires a lot of pharmacodynamic and pharmacy exploration

Method used

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  • Arctigenin sublingual preparation
  • Arctigenin sublingual preparation
  • Arctigenin sublingual preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Arctigenin Sublingual Tablets

[0021] Arctigenin

[0022] Preparation process: dry the main drug and various auxiliary materials, crush and sieve pretreatment, mix the main drug with powdered sugar, lactose, and sodium carboxymethyl cellulose, and use pure water as a binder to prepare the mixed material The soft material is granulated through a 20-mesh sieve and dried at 60°C to prepare dry granules. Magnesium stearate is added to the above dry granules, blended, and compressed into tablets.

Embodiment 2

[0023] Example 2 Arctigenin Sublingual Tablets

[0024] Arctigenin

[0025] Preparation process: the above components are dried, pulverized, sieved, pretreated, mixed evenly and directly compressed into tablets.

Embodiment 3

[0026] Embodiment 3 arctigenin film agent

[0027] Arctigenin 3%, Azone 2.5%, Propylene Glycol 5%, Add Acrylic Ester Copolymer Emulsion to 100%, Grind it evenly, spread it on 80μm thick PVC film, and dry it at 70±5℃ to form a transparent solid dispersion sheet, That is, the transdermal film agent of arctigenin.

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Abstract

The invention claims protection for an arctigenin sublingual preparation and a use of the arctigenin sublingual preparation in the preparation of a medicine for treating a disease, and belongs to the field of medicines. According to the arctigenin sublingual preparation provided by the invention, a biological viscous material and an absorption promoter are added to effectively improve the absorption characteristic of the arctigenin sublingual preparation. When the arctigenin sublingual preparation provided by the invention is applied to treating a tumor, the tumor inhibition ratio of the medicine can be obviously improved, and the survival rate of a patient can be improved. The arctigenin sublingual preparation provided by the invention is high in biological availability, the treatment compliance of the patient can be improved, and therefore the arctigenin sublingual preparation has a good medical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing arctigenin, in particular to a sublingual oral preparation of arctigenin and its application for treating related diseases, and belongs to the field of medicine. Background technique [0002] Burdock fruit is the dry and mature fruit of the biennial herb Burdock of Compositae. Burdock fruit is a commonly used traditional Chinese medicine. Traditional Chinese medicine believes that it has the effects of dispersing wind-heat, clearing lungs and rash, relieving throat and dispelling stagnation, detoxifying and reducing swelling. Erysipelas, carbuncle sore. Western medicine believes that in addition to its pharmacological effects such as diuresis, eliminating accumulation, eliminating phlegm and stopping diarrhea, it is also used for dietary therapy of constipation, high blood pressure, and high cholesterol. Burdock mainly contains lignin compounds, mainly arctiin and arctigenin. According...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P35/00
Inventor 赵志全郝贵周陈凯姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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