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Antibacterial hydrogel wound coating film and wound paste prepared by using coating film

A technology of hydrogel and coating, applied in medical science, absorbent pads, bandages, etc., can solve the problem of unsatisfactory antibacterial performance, achieve the effect of preventing infection, good antibacterial effect, and promoting healing

Active Publication Date: 2013-12-18
HENAN KEGAO RADIATION CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its antibacterial performance is not ideal enough

Method used

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  • Antibacterial hydrogel wound coating film and wound paste prepared by using coating film
  • Antibacterial hydrogel wound coating film and wound paste prepared by using coating film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The mass percentage composition of the antibacterial hydrogel wound coating is: silver norfloxacin 1% (2g), polymer 20% (40g), plasticizer 4% (8g) and the balance of water (150g).

[0022] Preparation Process:

[0023] Add 40.0 grams of polyvinyl alcohol (1700 degree of polymerization, 99% saponification degree) and 120.0 grams of deionized water into a 250ml three-necked flask with stirring, thermometer and heating device, start stirring, raise the temperature to 95°C, and keep it warm for 12 hours , to dissolve completely; add 8.0 grams of glycerin, stir for 1 hour, make the mixture uniform, cool to 40 ° C, add 32 grams of norfloxacin silver aqueous suspension (2 grams of norfloxacin silver is added to 30 g of water to form a suspension), stir 1 hour, making the mixture uniform to obtain the compound;

[0024] Take 4.0 grams of the above-prepared compound, pour it into a 10cm×10cm plastic bag, vacuumize, fill with nitrogen, and seal it with two pieces of flat glass t...

Embodiment 2

[0028] The film was prefabricated according to the operation process of Example 1.

[0029] Place the prefabricated film in an electron accelerator and irradiate under the conditions of 1.5MV and 10mA, with an absorbed dose of 40kGy.

[0030] After the above operation process, a yellow transparent film is obtained, which is the antibacterial hydrogel wound covering film, and the equilibrium water absorption rate is 176.87%. The color of the antibacterial hydrogel wound coating is uniform and transparent, which proves that norfloxacin silver is evenly distributed.

[0031] The antibacterial hydrogel wound cover film is pasted on the side of the non-woven fabric coated with pressure-sensitive adhesive to form a Band-Aid.

Embodiment 3

[0033] The mass percentage composition of the antibacterial hydrogel wound coating is: polyvinyl alcohol (polymerization degree: 1700, saponification degree: 99%) 16.0%, polyoxyethylene (molecular weight: 300,000) 4.0%, sorbitol 4.0%, fluorine The content of silver phenicate is 0.2%, and the rest is deionized water.

[0034] Different from the preparation process of Example 1, the above-mentioned prefabricated film was placed in 60 In the Co-γ radiation source, at a dose rate of 10kGy / min, the absorbed dose is 10kGy for 1 hour of irradiation.

[0035] After the above operation process, a yellow translucent film is obtained, which is the antibacterial hydrogel wound coating, and the equilibrium water absorption rate is 299.30%. The color of the antibacterial hydrogel wound coating is uniform and transparent, which proves that the distribution is uniform.

[0036] The prepared antibacterial hydrogel wound covering film is pasted on the non-woven fabric to form a bandage.

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Abstract

The invention belongs to the field of medical products, particularly relates to an antibacterial hydrogel wound coating film and a preparation method thereof, and also relates to a wound paste prepared by using the coating film. The antibacterial hydrogel wound coating film comprises the following components by mass percent: 0.1-5% of norfloxacin silver, 5-30% of polymer, 0-10% of plasticizer and the balance of water. The antibacterial hydrogel wound coating film disclosed by the invention can be directly used for covering a wound to treat various wounds caused by burns, scalds, trauma, surgical operations and the like, and is capable of absorbing body fluid secreted by the wounds and keeping the wounds in a clean and moist state. Meanwhile, the coating film also has good antibacterial effect, so that invasion of bacteria is cut off; infection is prevented; union of the wounds can be facilitated.

Description

technical field [0001] The invention belongs to the field of medical products, and in particular relates to an antibacterial hydrogel wound covering film and a preparation method thereof, and at the same time relates to a wound dressing made of the covering film. Background technique [0002] In daily life, during wars, when natural disasters occur, it is inevitable for people to encounter trauma, burns, gunshot wounds, scalds, and burns, especially during wars or when natural disasters occur, and in some cases, wounds caused by surgical operations . The traditional wound treatment method is to cover the wound with gauze after cleaning and sterilization. It is a dry treatment and needs to be replaced frequently. During the replacement process, the dressing will adhere to the wound, which will bring pain to the patient. [0003] In recent years, people have invented hydrogel wound coverings. Hydrogels have high water absorption, water retention and good biocompatibil...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/24A61L15/44
Inventor 崔国士党从军宋连卿李平冉云根崔攀马晨红
Owner HENAN KEGAO RADIATION CHEM TECH
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