A Confined Bed Adsorption Separation Method

Abstract

The invention discloses a constraint bed adsorption separation technology. The constraint bed adsorption separation technology is mainly characterized in that an adsorbent is constrained on a fixed framework by utilizing an external force, gaps among a column body, the fixed framework, the adsorbent or a 'constraint assembly' constrained by an 'aggregate' allow solid particles to pass through, and as long as the flow velocity of fluid does not exceed a 'constraint force', the adsorbent can keep an 'initial constraint state' and is regularly arranged in a column of a constraint bed respectively according to three modes, namely hard constraint, soft constraint and aggregate constraint. The constraint bed adsorption separation technology can be used for directly extracting target ingredients from particle materials just like expanded bed adsorption to obtain a separation effect similar to that of a fixed bed, and also avoids the special conditions such as the adsorbent with certain density and particle size distribution, a fluid distributor system and specific flow velocity of the fluid necessary for an expanded bed; an expansion process is very convenient, low in cost and convenient to operate, and the constraint bed adsorption separation technology can be used for a material separation process, and especially can be used for a reaction process.

Description

Technical field [0001] The invention relates to the technical field of novel separation, in particular to a constrained bed adsorption separation method. Background technique [0002] Expanded Bed Adsorption (EBA) technology was developed in the 1990s. [0003] A new type of separation and purification technology that can directly capture the target product from the fermentation broth or cell homogenate, and integrate solid-liquid separation, concentration and initial purification into one operation unit, reducing the number of operation units, shortening the operation time, and saving The production cost is known as the first new unit operation in recent decades. The expanded bed is also called a stable fluidized bed (StabilizedFluidizedBed). The filler in the bed is in a critical fluidized state. It is a special case of a fluidized bed, but it is based on the stability of solid fillers (such as adsorbents and catalysts) in the expanded bed. For classification behavior, the numb...

AI Technical Summary

Problems solved by technology

One is that the solid filler in the expanded bed should have a relatively large density and a certain particle size distribution, so that when the bed expands, the large and heavy particles are at the bottom of the bed, and the small and light particles are at the top of the bed, forming a stable The classification behavior of this kind of expanded bed adsorbent is mostly monopolized by large foreign companies, and the price is expensive; second, the expanded bed device must be conducive to the formation of plug flow, especially at the fluid inlet and outlet of the device. There is an obvious jet area, such as the fluid distributor system launched by Denmark’s UpFront company named FastLine; third, a special operation method must be adopted, and the fluid flow rate should be controlled between the minimum fluidization velocity and the terminal velocity, especially for adsorbent adsorption. The properties of the corresponding substances will change, and it is necessary to adjust the flow rate, otherwise the state of the expanded bed cannot be maintained, and even the collapse of the expanded bed may occur

[0005] Among them, the design of fluid distributor and adsorbent is the most critical. In recent years, scholars from various countries have conducted a lot of research on this. Although some scholars have reported the application examples of pilot scale and production scale, most of the development of EBA process still only stays in the laboratory scale

The main reason is the above requirements on the expanded bed device, adsorbent and operation mode, especially the bridging effect caused by cell debris, nucleic acid anion substances, etc. Adjusting the flow rate and other operating conditions will also cause the collapse of the expanded bed, and the state of the expanded bed cannot be maintained. The industrialization of EBA technology has encountered a "bottleneck", which greatly limits the wide application of EBA technology in the field of bioengineering

Images