Pure aqueous phase synthesis method of β-aminocarbonyl compound

Abstract

The invention provides a method for synthesizing a beta-amino-carbonyl compound by a pure water phase. Water is used as a reacting solvent, aldehydes, amines and ketones are used as raw materials, and salicylic acid or salicylic acid derivatives is or are adopted as a catalyst to react. The method opens a new low-cost, green and effective way to the preparation of beta-amino-carbonyl compounds, and has the advantages that a target product is good in selectivity and high in yield; the catalyst is small in dose and does not need to be separated from the solvent after the reaction is completed, and can be recycled directly in an aqueous solution manner; experiment results prove that the catalyst still has high catalytic activity after being recycled for 5 times, and the yield of the product is basically the same.

Description

technical field

[0001] The invention belongs to the technical field of catalytic organic synthesis, and specifically relates to a method for synthesizing beta-aminocarbonyl compounds by using salicylic acid or salicylic acid derivatives as catalysts. Background technique

[0002] β-Aminocarbonyl compounds are key intermediates in the synthesis of drugs and natural products (β-amino alcohols, β-amino acids, β-lactams, etc.), and are widely used in organic synthesis. Various types of compounds can be obtained from β-aminocarbonyl compounds. β-Aminocarbonyl compounds are also an important class of biologically active substances, which have various biological activities such as antitussive, antibacterial, anti-inflammatory, anticancer, antiviral, sedative, analgesic, antihypertensive, edema inhibitory, and anticoagulant. From the perspectives of environmental protection, energy saving, and atom economy, the direct, efficient and selective construction of β-aminocarbonyl compoun...