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Method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy

A tetracycline hydrochloride, terahertz time domain technology, applied in the measurement of color/spectral characteristics, phase influence characteristics and other directions, can solve the problems of difficult preparation, high use cost, poor stability of antibodies, etc., and achieve good repeatability and relatively accurate. , Easy to operate effect

Inactive Publication Date: 2013-12-25
ZHEJIANG UNIV
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Immunization method has the advantages of strong specificity and high sensitivity, but the cost is high, the antibody stability is poor, and the preparation is difficult

Method used

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  • Method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy
  • Method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy
  • Method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0053] The tetracycline hydrochloride is tetracycline hydrochloride from Aladdin Reagent Company (product number: T105493)

[0054] The mass percentages (g / 100g) of the tetracycline hydrochloride tablet samples are 0%, 1%, 3%, 5%, 10%, 20%, 30%, 40%, 50%.

[0055] The terahertz time-domain spectroscopy system is a model Z-3 terahertz time-domain spectroscopy system produced by Z-Omega Company.

[0056] Mix and grind tetracycline hydrochloride powder and high-density polyethylene powder in different proportions, and press them into disk-shaped sheets with a diameter of 13mm and a thickness of 1-2mm with a tablet machine to obtain tetracycline hydrochloride tablets with different mass percentages; turn on the laser until After the output power is stable, check whether the light in the optical path is collimated; turn on the laptop, and set the parameters on the program panel of the Labview software; seal the optical path, fill with nitrogen, and the humidity drops, and the laser c...

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Abstract

The invention discloses a method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy, which comprises the following steps: preparing tetracycline hydrochloride tablet samples with different mass percents; acquiring terahertz time-domain spectra of the tetracycline hydrochloride tablet samples; performing Fourier transformation treatment on the terahertz time-domain spectra of the tablet samples, and obtaining absorption coefficients and refractive indices of the tablet samples through a formula; establishing a correction model according to the mass percent of each tablet sample and the corresponding absorption spectrum; and verifying and evaluating the correction model. According to the invention, the qualitative and quantitative detection of tetracycline hydrochloride can be realized; and the method has the advantages of simple sample pretreatment, easy operation, favorable repetitiveness, relatively accurate test result and the like. Thus, the method is of far reaching importance for detecting antibiotic residue in foods by using terahertz time-domain spectroscopy.

Description

technical field [0001] The invention relates to a method for detecting tetracycline hydrochloride, in particular to a method for detecting tetracycline hydrochloride by using terahertz time-domain spectroscopy. Background technique [0002] Tetracyclines are widely used in the prevention and treatment of animal diseases due to their excellent antibacterial properties, stability and low price. However, the abuse of tetracyclines leads to the enhancement of bacterial resistance and directly endangers the health of consumers. Therefore, in order to protect public health and safety, the detection of tetracyclines is very important. At present, the commonly used detection methods for tetracycline antibiotics mainly include microbiological methods, chromatography methods, and immunological methods. The pharmacopoeia generally adopts the microbial method, which can reflect the biological potency, but the operation is cumbersome and the error is large. Chromatographic analysis ha...

Claims

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Application Information

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IPC IPC(8): G01N21/41G01N21/31
Inventor 应义斌秦坚源谢丽娟
Owner ZHEJIANG UNIV
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