Preparation method for monodisperse functionalized polymer microsphere with surface chain transfer activity

A technology of chain transfer and functionalization, which is applied in the field of preparation of monodisperse surface chain transfer active functionalized polymer microspheres, can solve problems such as poor spheroid formation, achieve stable surface functional groups, high chain transfer activity, and synthetic conditions easy to control effects
CN103483477AInactive Publication Date: 2014-01-01NORTHWESTERN POLYTECHNICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWESTERN POLYTECHNICAL UNIV
Publication Date
2014-01-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method for a monodisperse functionalized polymer microsphere with the surface chain transfer activity. An RAFT (Reversible Addition-Fragmentation Chain-Transfer) distillation-precipitation polymerization method is adopted, and polyene monomers or polyene and monoene mixed monomers are used, as a result, the monodisperse polymer microsphere of which the crosslinking degree is greater than 30 percent, particle diameter is within a range of 50 nanometers-8 micrometers, particle dispersion index is 1.038-1.164, surface chain transfer functional group content is 0.75-1.88 mmol / g, and surface can be further modified, is prepared. The preparation method has the characteristics that a particle diameter and surface functional group content are controllable; surface functional groups are stable; chain transfer activity is high; metal impurities difficult to treat are not introduced; synthesis conditions are easy to be controlled; the price of the raw material is low, and the like. The prepared monodisperse surface functionalized polymer microsphere can be applied to a chromatogram stationary phase, medicine slow release, catalysts, active bio-molecule carries and the like.
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Description

technical field

[0001] The invention relates to a method for preparing monodisperse surface chain transfer active functionalized polymer microspheres, in particular to a method based on reversible addition-fragmentation chain transfer (RAFT) active free radical distillation precipitation polymerization method to prepare monodisperse surface with reversible Method for Functionalizing Polymer Microspheres by Addition-Fragmentation Chain Transfer of Reactive Groups. Background technique

[0002] In recent years, polymer core-shell microspheres have been widely used in solid phase chromatography packing, separation analysis, drug release control, immunoassay and other fields, and the method of preparing core-shell microspheres has also attracted international academic circles. and great attention from the industry. At present, the "grafting from..." method is the most direct and effective method for preparing shell-core polymer microspheres. Due to the introduction of RAFT rea...

Claims

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