Compound cottonrose hibiscus effervescent vaginal dilation suppository as well as preparation method and detection method thereof

A vaginal expansion suppository and detection method technology, applied in the directions of suppository delivery, pharmaceutical formulations, material inspection products, etc., can solve the problems of easy softening of suppositories, disordered expansion, no expansion effect of cotton sliver, etc., to avoid secondary infection, prevent Outflow, the effect of improving curative effect

Active Publication Date: 2014-01-08
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The curative effect of compound Furong effervescent suppository has been clinically confirmed for many years, but there are still some technical problems in itself, such as the low bioavailability of traditional compound Furong effervescent suppository; Mucous membrane produces irritation; Under high temperature and high humidity environment, described suppository is easy to soften, affects the stabil...

Method used

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  • Compound cottonrose hibiscus effervescent vaginal dilation suppository as well as preparation method and detection method thereof
  • Compound cottonrose hibiscus effervescent vaginal dilation suppository as well as preparation method and detection method thereof
  • Compound cottonrose hibiscus effervescent vaginal dilation suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098]

[0099] Preparation:

[0100] 1) Preparation of drug-containing matrix:

[0101] a. Semi-synthetic coconut oil ester and fractionated castor oil are placed in a water bath for heating and melting to obtain a melt;

[0102] b. the preparation of Chinese medicine composition:

[0103] Ⅰ. Weigh the Sophora flavescens, Cortex Phellodendri and Artemisia argyi leaves in the prescribed amount, crush them, add water to decoct three times, the first water consumption is 10 times of the total weight of Sophora flavescens, Cortex Phellodendri and Artemisia argyi leaves, decoct for 3 hours, and the second water consumption is 5 times the total weight of ginseng, phellodendron and mugwort leaves, decoct for 2 hours, the third water consumption is 3 times the total weight of sophora flavescens, phellodendron and mugwort leaves, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate until thick Paste, spray dried into fine powder;

[0104] Ⅱ. Weigh the F...

Embodiment 2

[0111]

[0112] Preparation:

[0113] 1) Preparation of drug-containing matrix:

[0114] a. semi-synthetic fatty acid glycerides and fractionated palm oil are placed in a water bath for heating and melting to obtain a melt;

[0115] b. the preparation of Chinese medicine composition:

[0116] Ⅰ. Weigh the Sophora flavescens, Cortex Phellodendri and Artemisia argyi leaves in the prescribed amount, crush them, add water to decoct three times, the first water consumption is 10 times of the total weight of Sophora flavescens, Cortex Phellodendri and Artemisia argyi leaves, decoct for 3 hours, and the second water consumption is 5 times the total weight of ginseng, phellodendron and mugwort leaves, decoct for 2 hours, the third water consumption is 3 times the total weight of sophora flavescens, phellodendron and mugwort leaves, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate until thick Paste, spray dried into fine powder;

[0117] Ⅱ. Weigh the...

Embodiment 3

[0125]

[0126] Preparation method: Prepare 100 egg-shaped suppositories according to the method described in Example 2, each weighing about 1.8g.

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Abstract

The invention relates to a compound cottonrose hibiscus effervescent vaginal dilation suppository as well as a preparation method and a detection method thereof. The dilation suppository comprises a Chinese medicine composition, citric acid, sodium bicarbonate, a matrix and a dilation carrier, wherein the Chinese medicine composition is prepared from six raw medicinal materials, such as radix sophorae flavescentis and cottonrose hibiscus leaves; dalbergia wood and dandelion are added in the Chinese medicine composition, so that the curative effect of the compound cottonrose hibiscus effervescent vaginal dilation suppository on the trichomonas vaginitis and the colpitis mycotica can be improved; the polyethylene dodecyl stearate has the capability of improving the absorption of the Chinese medicine composition; a capsule shell is wrapped on the outer layer of the compound cottonrose hibiscus effervescent vaginal dilation suppository, so that the stability and the flexibility of the dilation suppository can be improved and the irritation of the dilation suppository can be reduced; in addition, the compound cottonrose hibiscus effervescent vaginal dilation suppository adopts six unique technologies and has the beneficial effects of preventing outflow of medicine liquor and preventing secondary infection, and is high in stability, durable in curative effect and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a compound hibiscus effervescent vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] The compound hibiscus effervescent suppository is prepared from sophora flavescens, cnidium, Phellodendron cortex, hibiscus leaves, mugwort leaves, alum and appropriate amount of auxiliary materials; the compound hibiscus effervescent suppository has the effects of clearing away heat and dampness, killing insects and relieving itching, and is used for damp-heat type Pruritus vulvae includes trichomonas vaginitis and fungal vaginitis. The main symptoms are genital flushing, swelling and itching, profuse leukorrhea, yellow pus or foamy rice swill or bean dregs, foul smell, red tongue and yellow fur Greasy, moist pulse. [0003] The curative effect of compound Furong effervescent suppository has been clinically confirmed for many ye...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K47/32A61K9/02G01N33/15G01N5/04A61P15/02A61P31/10A61P33/02A61K36/48A61K36/288
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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