Chondroitin sulfate production process

A chondroitin sulfate and production process technology, which is applied in the field of biochemical pharmaceuticals, can solve the problems of chemical property damage, low product safety, and low chondroitin B content, and achieve the goals of reducing production costs, simplifying processes, and increasing production volume Effect

Inactive Publication Date: 2014-01-08
河北三鑫实业集团有限公司
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention aims at the destruction of the chemical properties of the product itself by high temperature, strong alkali and strong oxidant in the traditional production process of chondroitin sulfate tablets, resulting in defects such as low chondroitin B content in the product and low product safety, and provides a low production cost, The extraction process does not contain chlorine, and the production process of chondroitin sulfate with perfect performance of each chemical component in chondroitin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Raw material preparation: 2 tons of sun-dried aged pork nose bones, crushed to a particle size of 3-5 mm, the crushing equipment is preferably a crusher used in the plastics industry; the crushed raw materials are placed in a soaking tank, and an amount equivalent to the weight of the raw materials is added 8 times of water, soaked for 25 hours, and then sent to a pulper to make raw material slurry, the pulper is preferably a medium-concentration refiner for the paper industry.

[0027] Hydrolysis and enzymatic extraction: first put the soaked raw materials into the reaction kettle, heat and boil, then keep warm for 15 minutes to make the collagen thermally denatured and precipitate oil, then cool down to 53°C with cooling water, remove the slick oil and process it separately; Adjust the pH value of the heat-denatured liquid in the reactor to 8.5 with alkali, add 120 kg of disintegrating enzyme, adjust the speed of the reactor at 150 rpm, and keep it warm for 5 hours for...

Embodiment 2

[0032] The production process is the same as in Example 1. In the process of filtration and alcohol precipitation, all the alcohol precipitation liquid is concentrated to one-third of its volume, kept at 45-50°C for heat preservation, and then the concentrated liquid is decolorized and deodorized with bamboo charcoal. Alcohol reaches 85%, and then alcohol precipitation is carried out, and the alcohol precipitation is sent to a drying box to be dried at a step temperature of 85°C, 75°C, and 65°C to obtain 160 kg of food-grade collagen.

[0033] In the production process of chondroitin sulfate, in the process of filtration and alcohol precipitation, when the centrifuge is used to remove alcohol, the centrifuged bone residue and miscellaneous protein are sterilized and dried by a large tunnel microwave dryer; Micropowder milling powder, get 18.8 kilograms of feed grade bone meal.

[0034] In the production process of the chondroitin sulfate, the slick oil taken out of the reactio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a chondroitin sulfate production process. A raw material is crushed to form particles with a diameter of 3-5mm, the particles are placed into an immersion pool, water which is 7-8 times as heavy as the raw material is added into the immersion pool for immersion, the particles are sent into a pulping machine to form a raw material pulp, the raw material pulp is sent into a reaction kettle, is heated and boils, then heat preservation is carried out for 10-15 minutes, and floating oil is taken out after temperature reduction to obtain collagen thermal denaturation liquid; a PH value of thermal denaturation liquid caustic soda is adjusted, bacterial enzymes are added, heat-preservation enzymolysis is carried out for 5-6 hours, the temperature is reduced to be the same as the temperature of cold water, then the temperature is raised to 70-75 DEG C, and heat-preservation is carried out for 10-15 minutes; materials after enzymolysis are clarified and filtered, and a wet-state chondroitin course product is obtained after alcohol precipitation, dehydration and alcohol removal; decoloration, concentration, alcohol precipitation and alcohol removal are carried out on the wet-state chondroitin course product, and a chondroitin fine product is obtained after drying. Mechanical physical degradation is carried out, the chondroitin is prevented from being degraded under a high temperature, the yield rate is improved, production cost is reduced, the yield is improved, the production efficiency is improved, the production is increased and the process is scientific and environmentally friendly.

Description

technical field [0001] The invention relates to a production process of chondroitin sulfate containing full amount of chondroitin sulfate B, belonging to the field of biochemical pharmacy. Background technique [0002] At present, the known extraction process of chondroitin sulfate adopts a three-stage gradient method to extract, namely: 4-8 hours of high-temperature boiling hydrolysis extraction; 5-8 hours of sodium chloride and sodium hydroxide saline-alkali hydrolysis extraction; 6 hours of acidic, Enzymatic extraction with neutral or alkaline protease; the extract is filtered with a stainless steel manger and nylon filter cloth, hydrogen chloride and sodium hydroxide are used as pH regulators, and hydrogen peroxide is used for oxidative decolorization. In the final chondroitin sulfate component: chondroitin sulfate B can only reach 12.6% of the total chondroitin component, which is seriously missing. Because the molecular structure of the product is destroyed by high te...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 周立新
Owner 河北三鑫实业集团有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap