Application of peptide compound in rhizoma sparganii

A compound and peptide technology, applied in the field of medicine, can solve the problems of active ingredients not being found, staying, and limiting the popularization and application of triangular compounds, and achieve the effect of filling the technical gap and improving anticoagulant activity

Active Publication Date: 2014-01-22
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the chemical composition of trigonium is complex, containing compounds such as flavonoids and flavonoid glycosides, phenylpropanoid glycosides, steroids and their glycosides, organic acids, although modern chemical and pharmacological studies have partially clarified

Method used

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  • Application of peptide compound in rhizoma sparganii
  • Application of peptide compound in rhizoma sparganii
  • Application of peptide compound in rhizoma sparganii

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Extraction, separation, purification and structural identification of compounds represented by formula (II)

[0029] 1. Experimental materials:

[0030] (1) medicinal materials

[0031] Trigonium medicinal material was purchased from Guangzhou Zhixin Pharmaceutical Co., Ltd., batch number 090301, and was identified as a plant of the genus Trigonum trigonum by the professor Li Shuyuan of the Chinese Medicine Identification Department of the School of Chinese Materia Medica of our school. Sparganium stoloniferum Buch.-Ham Dried tuber peeled off.

[0032] (2) Reagents and fillers

[0033] Chloroform (analytical grade, Tianjin Fuyu Fine Chemical Co., Ltd.);

[0034] Methanol (analytical pure, Tianjin Fuyu Fine Chemical Co., Ltd.);

[0035] Vanillin (Guangzhou Guanglianjin Chemical Factory);

[0036] Silica gel for column chromatography (80-100 mesh, 100-200 mesh, 200-300 mesh, Qingdao Ocean Chemical Factory);

[0037] Thin-layer chromatography silica gel (s...

Embodiment 2

[0068] Embodiment 2 Anticoagulant function test of compound described in the present invention

[0069] 1. Experimental materials

[0070] (1) Drugs

[0071] The cyclo-(phenylalanine-phenylalanine) prepared in Example 1.

[0072] (2) animals

[0073] SD rats, weighing 180-250 g, were provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine.

[0074] (3) Reagents

[0075] Heparin (sigma, batch number: 20120509);

[0076] Chloral hydrate (Guangzhou Sile Biochemical Reagent Co., Ltd.);

[0077] Prothrombin time PT kit (Nanjing Jiancheng Institute of Bioengineering, batch number: 20130314);

[0078] Activated partial thromboplastin time APTT kit (Nanjing Jiancheng Bioengineering Institute, batch number: 20130201);

[0079] Thrombin time TT kit (Nanjing Jiancheng Institute of Bioengineering, batch number: 20130314);

[0080] Normal saline (Guizhou Tiandi Pharmaceutical Co., Ltd., batch number A13011209);

[0081] Dimethyl sulfoxide...

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Abstract

The invention discloses application of a peptide compound in rhizoma sparganii in the preparation of medicines for resisting blood coagulation and/or thrombus. The structural formula of the peptide compound is as shown in a formula (I). The invention provides the peptide compound obtained from the rhizoma sparganii through the separation and the purification and the application thereof for the first time. The peptide compound has an elongation tendency effect on prothrombin time (PT), activated partial thromboplastin time (APPT) and thrombin time (TT) and very good anticoagulation activity and provides powerful basis for the development of antithrombus natural medicines.

Description

technical field [0001] The present invention relates to the technical field of medicine, and more specifically, relates to the application of a peptide compound in a triangular prism. Background technique [0002] Trigonum trigonum Sparganium stoloniferum The dried tuber of Buch.-Ham was first recorded in "Supplement to Materia Medica", and now it is recorded in "Chinese Pharmacopoeia". In addition to raw products and vinegar products used alone in traditional Chinese medicine, curcuma and astragalus are often used to enhance the curative effect. [0003] Modern pharmacological research shows that among the 35 commonly used drugs for promoting blood circulation and removing blood stasis, Sanleng ranks in the top 10 in terms of action strength, and is widely used in the treatment of cardiovascular and cerebrovascular diseases, tumors and various gynecological diseases. Especially for gynecological difficult diseases such as uterine fibroids and endometriosis, Sanleng has s...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P7/02C07D241/08
Inventor 梁生旺王淑美邓小慧陈舒茵刘贝胡旭光许亚韬
Owner GUANGDONG PHARMA UNIV
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