Application of Hijiki Sulfate Polysaccharide in Preparation of Anti-aging Drugs and Health Products
A technology of vegetable sulfuric acid and anti-aging, which is applied in the application field of hijiki sulfate polysaccharides in the preparation of anti-aging medicines and health products, and can solve the problem that anti-aging activity has not been reported, and the anti-aging effect of hijiki sulfate polysaccharides cannot be confirmed, etc. problems, to achieve the effect of prolonging life and broad application prospects
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Embodiment 1
[0018] Example 1 Extraction of hijiki sulfated polysaccharide
[0019] Take the water extraction method to extract the sulfated polysaccharides of hijiki, the specific method is as follows:
[0020] (1) Extraction of crude polysaccharides from hijiki
[0021] Raw materials of hijiki were stirred and leached in 80% ethanol solution for 24 hours, and leached twice to remove pigment, etc., to obtain ethanol extract and algae residue respectively. Extract the residue with hot water, mix it at a ratio of 1:10, adjust the pH to 4 with 0.1% HCl solution, extract it in a water bath at 30°C for 3 hours, and filter the extracted solution with 200-mesh gauze , and then vacuum concentrated and vacuum freeze-dried for 24 hours to obtain the residue water extract, which is the crude polysaccharide of hijiki.
[0022] (2) Extraction of hijiki sulfated polysaccharide
[0023] Concentrate the water extract of hijiki crude polysaccharide with a rotary evaporator, the conditions are: rotary ...
Embodiment 2
[0025] Example 2 Anti-aging test of hijiki sulfated polysaccharide
[0026] Drosophila lifespan experiments were used to study the anti-aging effect of seaweed active polysaccharides, and the anti-aging research and the application of more mature astragalus polysaccharides were used as controls to calculate the average lifespan (the arithmetic mean of the entire lifespan of each group of fruit flies) and the maximum lifespan (each group The arithmetic mean of the lifespan of the last 10 fruit flies that died) and the half-death time (the arithmetic mean of the lifespan of the first half of the fruit flies) were used as evaluation indicators.
[0027] 1 Experimental method
[0028] 1.1 Drosophila longevity experiment pre-treatment
[0029] ①Basic medium formula: See Table 1 for the components of the medium. The above components were dissolved in tap water, and the natural pH was maintained.
[0030] Table 1 Basal medium formula
[0031] name corn flour lactos...
Embodiment 3
[0046] Example 3 Anti-aging Drugs and Health Products Made from Hijiki Sulfate Polysaccharide
[0047] 1. Tablet
[0048] (1) The prescription of the preparation is as follows:
[0049]
[0050] (2) The preparation process is:
[0051] 1. Extraction: Extract the crude polysaccharide of Hijiki from Hijiki according to the extraction method described in Example 1, concentrate the obtained extract, and set aside;
[0052] ② Refining: the above-mentioned hijiki crude polysaccharide is concentrated to a certain concentration of thick paste, add an equivalent amount of 95% ethanol, mix well, let stand in refrigeration for more than 12 hours, filter, recover ethanol from the filtrate, and then continue to concentrate to thick paste ;
[0053] ③Granulation: Take 10g of the above-mentioned thick paste-like hijiki sulfate polysaccharide, add an appropriate amount of ethanol, starch and dextrin soft material, pass through a No. 1 sieve (12-14 mesh) to make granules;
[0054] ④ D...
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