A kind of cefdinir capsule and preparation method thereof
A technology of cefdinir and dini capsules, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., to achieve the effects of improving bioavailability, taste, taste and dissolution
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Embodiment 1
[0115] Formulation prescription:
[0116] Product name
Amount per capsule (mg)
[0117] Cefdinir
100
10
10
5
10
Silica
5
5
Total
145
[0118] Preparation Process:
[0119] (1) Pretreatment of raw and auxiliary materials: pass the prescribed cefdinir, microcrystalline cellulose, and lactose through a 200-mesh sieve, and mix croscarmellose sodium, hydroxypropyl cellulose and magnesium stearate through a 60-mesh sieve, The silicon dioxide is passed through a 120-mesh sieve; the raw materials of cefdinir, microcrystalline cellulose, and lactose are mixed through a 60-mesh sieve for use;
[0120] (2) Mixing: Add the resulting mixture of cefdinir, microcrystalline cellulose and lactose, together with the remaining croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate, and silicon dioxide to the three-dimensional movement Mixer for 35 minutes;
[0121] (...
Embodiment 2
[0124] Formulation prescription:
[0125] Product name
Amount per capsule (mg)
Cefdinir
100
20
5
10
Silica
5
Magnesium stearate
5
Total
145
[0126] Preparation Process:
[0127] (1) Pretreatment of raw and auxiliary materials: pass the prescribed cefdinir and lactose through a 200-mesh sieve, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate are mixed through a 60-mesh sieve, and the silicon dioxide is passed through 120 Mesh sieve; mix cefdinir raw material and lactose through a 60-mesh sieve, set aside;
[0128] (2) Mixing: Add the obtained mixture of cefdinir and lactose, together with the remaining croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate, and silicon dioxide, to the three-dimensional motion mixer and mix for 40 minutes ;
[0129] (3) Filling: add the evenly mixed powder to the filling machine, control the vacuum pressure -0.02~-0.06MPa, the distance between...
Embodiment 3
[0132] Formulation prescription:
[0133] Product name
Amount per capsule (mg)
Cefdinir
100
20
15
Silica
5
Magnesium stearate
5
Total
145
[0134] Preparation Process:
[0135] (1) Pretreatment of raw and auxiliary materials: pass the prescribed cefdinir and lactose through a 200-mesh sieve, hydroxypropyl cellulose and magnesium stearate are mixed through a 60-mesh sieve, and silicon dioxide is passed through a 120-mesh sieve; Mix lactose through a 60-mesh sieve and set aside;
[0136] (2) Mixing: add the resulting mixture of cefdinir and lactose, together with the remaining hydroxypropyl cellulose, magnesium stearate, and silicon dioxide, to the three-dimensional motion mixer and mix for 45 minutes;
[0137] (3) Filling: add the evenly mixed powder to the filling machine, control the vacuum pressure -0.02~-0.06MPa, the distance between the measuring discs is 0.04~1mm; the filling speed is 1200~1300 grains / min, and the medicine column...
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