Fructus schisandrae extract as well as preparation method and application thereof

A technology of Schisandra chinensis and extract, which is applied in the field of extract of Schisandra chinensis and its preparation and application, can solve problems such as waste, and achieve the effects of reducing waste, high lignan content, and unique activity

Active Publication Date: 2014-02-05
吉林省华惠生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In my country, the fruits and seeds of Schisandra chinensis have been used as medicine for a long time, and many parts other than the seeds of Schisandra chinensis are used, resulting in a very large waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: 1 kg of Schisandra root was soaked in 8L of water at 60°C for 12 hours, the water was released, the root of Schisandra was taken out and dried, and the dried root of Schisandra was extracted twice with 6L of 90% ethanol, 5L of reflux, and the ethanol extracts were combined ; Filtrate, concentrate the medicinal material and the extract ratio is 1.5L, add water to 3L to disperse the ethanol concentrate, carry out steam distillation, accept the steam distillate at 1 times the weight of the medicinal material, continue to concentrate to 1L, leave the extract overnight, separate In the lower water layer, add 0.3L of 90% ethanol to the above extract and then concentrate to obtain 115g of Schisandra chinensis root ethanol extract.

[0027] 115 g of the above-mentioned Schisandra chinensis root ethanol extract was put on the column with 500 g of macroporous adsorption resin, washed with water until colorless, eluted with 50% ethanol for two column volumes, then eluted...

Embodiment 2

[0028] Example 2: 100 g of the rhizome xylem of Schisandra chinensis, soaked in 800ml, 95% ethanol for 12 hours, reflux extraction for 2 hours, then reflux extraction with 600ml of 95% ethanol for 1.5 hours, combined ethanol extract; filtered, concentrated to obtain ethanol from the rhizome of Schisandra chinensis Extract 10.5g. The ethanol extract of the rhizome xylem of Schisandra chinensis is refined with macroporous adsorption resin, take 30g of macroporous adsorption resin, first wash with water until colorless, then wash with 300ml of 60% ethanol, and finally elute with 400ml of 95% ethanol, collect 95% ethanol to wash Deliquoring, recovering ethanol under reduced pressure to obtain 3.25 g ethanol extract of Schisandra rhizome xylem, containing 18% (mass percentage) schisandrin A. The determination of the content is to use Schisandra Methanol as the reference substance, and to measure it by high performance liquid chromatography. The chromatographic conditions are: chrom...

example 3

[0029] Example 3 The hangover experiment of the extract of Schisandra chinensis. The application of the Schisandra chinensis extract of the present invention in hangover protection and liver protection is proved by the following experiment (the effect of Schisandra schisandra root and xylem rhizome extract on the whole blood ethanol content of mice).

[0030] Materials and Methods

[0031] 1.1 Experimental materials

[0032] 1.1.1 Experimental samples and reagents were provided by the Animal Room of Yanbian University School of Medicine. Schisandra chinensis root ethanol extract and Schisandra rhizome xylem ethanol extract homemade. Liquor used in the experiment: Erguotou liquor, alcohol content 50% (v / v). Bought in a supermarket, use an alcohol meter to measure its alcohol content (unchecked). Ethanol standard solution: make 0.02mg / ml with distilled water

[0033] 1.1.2 Experimental animals: Kunming mice, half male and half male, weighing 8-22g.

[0034] 1.1.3 Experime...

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PUM

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Abstract

The invention discloses a fructus schisandrae extract which refers to a fructus schisandrae rhizome xylem ethanol extract which contains 18% of schizandrin, and is extracted from fructus schisandrae rhizome xylem. According to the fructus schisandrae extract, the problem of shortage of fructus schisandrae can be solved, fructus schisandrae roots and the fructus schisandrae rhizome xylem thrown away in the processing process are fully utilized, and the waste is reduced; the extract is high in lignans such as schizandrin with different compositions and contents in comparison with those in fructus schisandrae fruits and rattans, and is unique in pharmacological activity. The invention further discloses a preparation method for the fructus schisandrae extract and an application of the fructus schisandrae extract to dispelling an alcohol effect and protecting the liver.

Description

[0001] The application of the present invention is a divisional application, the original application date: August 13, 2012, the application number: 201210285907.8, the name of the invention: Schisandra chinensis extract and its preparation method and application. technical field [0002] The invention relates to an extract of Schisandra chinensis and its preparation method and application. Background technique [0003] Schisandra chinensis (Schisandra chinensis (Turcz.) Baill) root is the root of Schisandra chinensis (Turcz.) Baill. Schisandra chinensis has a long-standing reputation at home and abroad. It tastes sour, sweet, and warm in nature. Commonly used precious Chinese herbal medicines in my country have the functions of nourishing qi, nourishing the kidney, astringing the lungs, astringent essence, promoting body fluid, quenching thirst, improving intelligence, and calming the nerves. They are mainly used in the treatment of chronic hepatitis, insomnia, dreamy palpi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K36/79A61P1/16A61P39/02A61P37/04A61K125/00
Inventor 金光洙雒佳
Owner 吉林省华惠生物科技有限公司
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