Application of glipizide in preparing medicine for treating tumors

A technology for glipizide and tumor drug, which is applied to the application field of glipizide in the preparation of tumor drugs, and can solve the problems of no report of compound application, no anti-angiogenesis effect of glipizide, elevated blood sugar, etc. , to achieve the effect of inhibiting tumor angiogenesis, inhibiting growth and metastasis, and inhibiting tumor proliferation

Active Publication Date: 2014-03-12
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far there is no clear information on whether elevated blood sugar can induce cancer
[0004] At present, there is no report on the anti-angiogenic effect of glipizide, let alone the application of this compound in antitumor drugs

Method used

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  • Application of glipizide in preparing medicine for treating tumors
  • Application of glipizide in preparing medicine for treating tumors
  • Application of glipizide in preparing medicine for treating tumors

Examples

Experimental program
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Embodiment Construction

[0014] The following will illustrate the inhibitory effect of glipizide on tumor angiogenesis, tumor growth and metastasis in combination with specific experiments. Using the most commonly used in vivo assay models for the study of angiogenesis—chicken chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models, firstly, using these two models to preliminarily detect the effect of glipizide on angiogenesis , and then through subsequent experiments to verify that glipizide has an inhibitory effect on tumor angiogenesis and cell proliferation, thereby inhibiting tumor growth and metastasis. Glipizide described in the experiment was purchased from Sigma Company.

[0015] 1. Glipizide inhibits angiogenesis in chick chorioallantoic membrane (CAM)

[0016] 1) Treatment of chicken embryos: Clean the surface of chicken embryos (purchased from the Breeder Factory of South China Agricultural University) that have been developing normally for 8 days, and then wipe them with 1:1 ...

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Abstract

The invention discloses an application of glipizide in preparing a medicine for treating tumors. The application proves that the glipizide has the effects of inhibiting tumor angiogenesis and tumor proliferation, so that growth and metastasis of tumors can be inhibited, and the effect of treating tumors can be achieved. Furthermore, the glipizide is applied to type 2 diabetes clinically, is safe and reliable, and is a tumor treating medicine with a development prospect.

Description

technical field [0001] The invention relates to a new application of glipizide, in particular to the application of glipizide in the preparation of drugs for treating tumors. Background technique [0002] Glipizide, the chemical name is 1-cyclohexyl-3-{4-[2-(5-methylpyrazine-2-amide)-ethyl]benzenesulfonyl}urea, and its structural formula is: . Glipizide is a disclosed compound, mainly used for the treatment of non-insulin-dependent (Ⅱ) diabetes mellitus, and it is a second-generation sulfonylurea oral hypoglycemic agent. [0003] Sulfonylureas have been clinically used to treat type Ⅱ diabetes since the 1950s. They bind to the sulfonylurea receptors on the surface of pancreatic β cells, trigger the closure of potassium ion channels to prevent the outflow of potassium ions from the cytoplasm, and open voltage-sensitive calcium ion channels at the same time, increasing the influx of extracellular calcium ions and promoting insulin It is secreted and released to the outside...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/64A61P35/00
Inventor 王丽京亓翠玲何晓东章倩倩
Owner GUANGDONG PHARMA UNIV
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